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    GENERATION AND PROFILING OF FULLY HUMAN HUCAL GOLD-DERIVED THERAPEUTIC ANTIBODIES SPECIFIC FOR HUMAN CD38
    11.
    发明公开
    GENERATION AND PROFILING OF FULLY HUMAN HUCAL GOLD-DERIVED THERAPEUTIC ANTIBODIES SPECIFIC FOR HUMAN CD38 审中-公开
    人CD38特异性全面人体金源性治疗性抗体的制备和分型

    公开(公告)号：EP3284756A1

    公开(公告)日：2018-02-21

    申请号：EP17193089.4

    申请日：2006-10-12

    申请人： MorphoSys AG

    发明人： TESAR, Michael ,  JÄGER, Ute

    IPC分类号： C07K16/28 ,  A61P35/00 ,  G01N33/574

    CPC分类号： C07K16/3061 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/732

    摘要： The present invention provides novel antibodies and methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such as the ability to bind CD38 of minipig origin and the ability to induce, by cross-linking, specific killing of cells that express CD38. There antibodies as well as the novel methods for using those antibodies can be used to treat, for example, hematological malignancies such as multiple myeloma.

    摘要翻译： 本发明提供了用于使用重组抗原结合区和抗体的新型抗体和方法以及含有对CD38特异性的这种抗原结合区的功能片段，所述CD38在各种病症或病症中起着不可缺少的作用。 这些方法利用了新发现的抗体和这些抗体的令人惊讶的性能，例如结合小型猪起源CD38的能力和通过交联诱导特异性杀伤表达CD38的细胞的能力。 这些抗体以及使用这些抗体的新方法可用于治疗例如血液恶性肿瘤如多发性骨髓瘤。

    Generation and profiling of fully human HuCAL GOLD-derived therapeutic antibodies specific for human CD38
    15.
    发明公开
    Generation and profiling of fully human HuCAL GOLD-derived therapeutic antibodies specific for human CD38 有权
    矿业和人CD38的完全人的HuCAL GOLD衍生的治疗性抗体的分析

    公开(公告)号：EP2860192A3

    公开(公告)日：2015-04-22

    申请号：EP14196972.5

    申请日：2006-10-12

    申请人： MorphoSys AG

    发明人： Tesar, Michael ,  Jäger, Ute

    IPC分类号： C07K16/28 ,  C07K16/40 ,  A61P35/00 ,  G01N33/574

    CPC分类号： C07K16/3061 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/732

    摘要： The invention provides a human antibody that is specific for CD38. The antibody of the invention has the ability to bind to CD38 of minipig origin and induce, by cross-linking, specific killing of cells, in particular tumor cells, expressing CD38. The invention further provides uses of this antibody for treating various disorders and conditions associated with undesired presence of CD38+ cells, including hematological and inflammatory diseases. The invention also provides diagnostic compositions and methods based on detecting the presence of CD38 in a tissue or a cell of minipig origin contacted with the antibody of the invention.

    摘要翻译： 本发明提供一种人类抗体特异性针对CD38一样。 本发明的抗体具有结合小型猪来源的CD38和诱导，通过交联，细胞的特异性杀伤，特别是肿瘤细胞，表达CD38的能力。 本发明提供了这种抗体的其它用途用于治疗各种病症和与CD38 +细胞，包括血液和炎性疾病的不希望存在的相关的病症。 因此本发明提供了基于检测CD38的在组织中的存在或与本发明的抗体接触小型猪来源的细胞诊断组合物和方法。

    NOVEL COLLECTION OF HCDR3 REGIONS AND USES THEREFOR
    20.
    发明授权
    NOVEL COLLECTION OF HCDR3 REGIONS AND USES THEREFOR 有权
    作者HCDR3区域小说集及其用途

    公开(公告)号：EP1979378B1

    公开(公告)日：2012-07-25

    申请号：EP06851829.9

    申请日：2006-12-15

    申请人： MorphoSys AG

    发明人： ENZELBERGER, Markus ,  THIEL, Stefanie ,  PRASSLER Josef ,  URLINGER Stefanie ,  ROTHE Christine

    IPC分类号： C07K16/00

    CPC分类号： C07K16/00 ,  C07K2317/565

    摘要： The present invention is directed to the preparation and use of a collection of antibody heavy chain complementarity determining region 3 (HCDR3) members, where diversity of the collection is a function of the length of the HCDR3 members. The diversity of the collection of HCDR3 regions substantially represents the natural amino acid distribution of HCDR3 in the human repertoire. This natural amino acid distribution can be represented by biasing the complete random distribution of amino acids, accordingly, in the HCDR3 encoding DNA sequence by using trinucleotide mutagenesis (TRIM) technology. A collection of HCDR3 members of the invention each can be comprised within a variable region of an antibody (or fragment thereof) to form a library of synthetic antibodies or antibody fragments. Synthetic antibody libraries of the present invention may be designed to include modular features, such as chemically synthesized 'master gene' framework regions, which may contain unique restriction sites flanking one or more CDR regions, including an HCDR3 region prepared as described herein. The invention also provides nucleic acid molecules encoding such diverse collection and methods of making and using the same.