公开(公告)号：EP2464657B1

公开(公告)日：2015-04-01

申请号：EP10741944.2

申请日：2010-08-06

申请人： MorphoSys AG

发明人： FRISCH, Christian ,  KNAPPIK, Achim ,  STRONGIN, Alex, Y ,  SHIRYAEV, Sergey, A

IPC分类号： C07K16/40 ,  C07K14/005 ,  C12Q1/37 ,  C07K16/10

CPC分类号： C12Q1/37 ,  C07K14/005 ,  C07K16/1081 ,  C07K16/40 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2770/24122 ,  G01N2333/185 ,  G01N2333/95 ,  G01N2500/04

公开(公告)号：EP2464657A1

公开(公告)日：2012-06-20

申请号：EP10741944.2

申请日：2010-08-06

申请人： MorphoSys AG

发明人： FRISCH, Christian ,  KNAPPIK, Achim ,  STRONGIN, Alex, Y ,  SHIRYAEV, Sergey, A

IPC分类号： C07K14/18 ,  C07K16/10 ,  G01N33/569

CPC分类号： C12Q1/37 ,  C07K14/005 ,  C07K16/1081 ,  C07K16/40 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2770/24122 ,  G01N2333/185 ,  G01N2333/95 ,  G01N2500/04

摘要： The present invention discloses novel screening strategies for the identification of binders that target the active site of enzymatic antigens. The present invention also discloses antigen-binding moieties which bind to the NS2B-NS3 Proteinase of West Nile Virus, in particular binders which bind to the active site, thereby inhibiting the enzymatic activity of the proteinase. The antigen-binding moieties of the present invention have numerous therapeutic and diagnostic applications.

公开(公告)号：EP1133565A2

公开(公告)日：2001-09-19

申请号：EP00947904.9

申请日：2000-06-30

申请人： MorphoSys AG

发明人： FRISCH, Christian ,  KRETZSCHMAR, Titus ,  HÖSS, Adolf ,  VON RÜDEN, Thomas

IPC分类号： C12N15/62 ,  C07K16/00 ,  C12N1/21 ,  C12N15/70

CPC分类号： C40B40/02 ,  C07K16/1018 ,  C07K16/2845 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2319/00 ,  C12N15/1037

摘要： The present invention relates to the generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs. The (poly)peptides are expressed as part of fusion proteins which are forming inclusion bodies on expression in host cells. The inclusion bodies are used to generate binding partners which bind specifically to said (poly)peptides. The specific binding partners, in particular immunoglobulins or fragments thereof, are useful for analysis and functional characterisation of proteins encoded by nucleic acid sequences comprising the corresponding genomic DNA fragments or ESTs. The invention further relates to nucleic acid molecules, vectors and host cells to be used in the methods of the present invention. The invention further relates to the use of fusion proteins comprising the first N-terminal domain of the geneIII protein of filamentous phage as fusion partner for the expression of a (poly)peptide/protein fused to said fusion partner, and to methods for the expression of (poly)peptide/proteins.

公开(公告)号：EP1133565B1

公开(公告)日：2010-09-22

申请号：EP00947904.9

申请日：2000-06-30

申请人： MorphoSys AG

发明人： FRISCH, Christian ,  KRETZSCHMAR, Titus ,  HÖSS, Adolf ,  VON RÜDEN, Thomas

IPC分类号： C12N15/62 ,  C07K16/00 ,  C12N1/21 ,  C12N15/70 ,  C12N5/10 ,  C12N1/19 ,  C07K14/705 ,  C07K14/045

CPC分类号： C40B40/02 ,  C07K16/1018 ,  C07K16/2845 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2319/00 ,  C12N15/1037

摘要： The present invention relates to the generation of specific binding partners binding to (poly)peptides encoded by genomic DNA fragments or ESTs. The (poly)peptides are expressed as part of fusion proteins which are forming inclusion bodies on expression in host cells. The inclusion bodies are used to generate binding partners which bind specifically to said (poly)peptides. The specific binding partners, in particular immunoglobulins or fragments thereof, are useful for analysis and functional characterisation of proteins encoded by nucleic acid sequences comprising the corresponding genomic DNA fragments or ESTs. The invention further relates to nucleic acid molecules, vectors and host cells to be used in the methods of the present invention. The invention further relates to the use of fusion proteins comprising the first N-terminal domain of the geneIII protein of filamentous phage as fusion partner for the expression of a (poly)peptide/protein fused to said fusion partner, and to methods for the expression of (poly)peptide/proteins.

公开(公告)号：EP2885639B1

公开(公告)日：2019-04-10

申请号：EP13752873.3

申请日：2013-08-08

申请人： MorphoSys AG

发明人： HÄRTLE, Stefan ,  FRISCH, Christian ,  KNAPPIK, Achim

IPC分类号： C07K16/42 ,  G01N33/68 ,  C07K16/24

公开(公告)号：EP2885639A1

公开(公告)日：2015-06-24

申请号：EP13752873.3

申请日：2013-08-08

申请人： MorphoSys AG ,  Härtle, Stefan ,  Frisch, Christian ,  Knappik, Achim

发明人： HÄRTLE, Stefan ,  FRISCH, Christian ,  KNAPPIK, Achim

IPC分类号： G01N33/564 ,  C07K16/00 ,  G01N33/53 ,  C07K16/24

CPC分类号： C07K16/4241 ,  C07K16/241 ,  C07K16/243 ,  C07K16/42 ,  C07K2317/30 ,  C07K2317/32 ,  C07K2317/55 ,  G01N33/686

摘要： The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and thus can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for use of said antibodies and antibody fragments.

摘要翻译： 本发明提供了特异性检测特异性同源抗原结合部分，特别是抗体及其抗原的复合物的抗体及其片段。 本公开的抗体不与所述同源抗原结合部分或所述抗原单独结合，因此可以例如使用。 直接检测抗原结合的抗原结合部分。 进一步披露的是使用所述抗体和抗体片段的方法。