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30 条记录 (耗时 0.021 秒)

    COMBINATION OF BENZIMIDAZOLE ANTI-CANCER AGENT AND A SECOND ANTI-CANCER AGENT
    16.
    发明公开
    COMBINATION OF BENZIMIDAZOLE ANTI-CANCER AGENT AND A SECOND ANTI-CANCER AGENT 审中-公开
    KOMBINATION AUS EINEM BENZIMIDAZOLKREBSMITTEL UND EINEM ZWEITEN KREBSMITTEL

    公开(公告)号：EP2131840A1

    公开(公告)日：2009-12-16

    申请号：EP08724338.2

    申请日：2008-03-07

    申请人： S*BIO Pte Ltd

    发明人： GOH, Kay Lin ,  KHNG, Hwee Hoon ,  SABANAYAGAM, Vasantha, Malar ,  SANGTHONGPITAQ, Kanda ,  STUNKEL, Walter ,  TAN, Yong Cheng ,  WOOD, Jeanette Marjorie

    IPC分类号： A61K31/4184

    CPC分类号： A61K31/4184 ,  A61P35/00 ,  A61K2300/00

    摘要： The present invention relates to a pharmaceutical composition for the treatment of cancer as well as methods of treatment of cancer that are based on the finding that certain benzimidazole based anti-cancer agents can be used in combination with a second anti- cancer agent to achieve desirable therapeutic outcomes. More specifically the present invention relates to a pharmaceutical composition including a benzimidazole based anti-cancer agent and a second anti-cancer agent. The invention also relates to methods of treatment of cancer including administration of a benzimidazole based anti-cancer agent and a second anti-cancer agent to a patient in need thereof.

    摘要翻译： 本发明涉及一种用于治疗癌症的药物组合物以及癌症治疗方法，其基于某些基于苯并咪唑的抗癌剂可与第二种抗癌剂组合使用以达到理想的效果 治疗结果。 更具体地，本发明涉及包含基于苯并咪唑的抗癌剂和第二抗癌剂的药物组合物。 本发明还涉及治疗癌症的方法，包括向有需要的患者施用基于苯并咪唑的抗癌剂和第二抗癌剂。

    IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
    18.
    发明公开
    IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS 有权
    咪唑并[1,2-A]吡啶衍生物：PRODUCTION和药物应用

    公开(公告)号：EP1863811A1

    公开(公告)日：2007-12-12

    申请号：EP06717188.4

    申请日：2006-03-20

    申请人： S*BIO Pte Ltd

    发明人： LEE, Ken Chi Lik ,  SUN, Eric T.

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

    CPC分类号： C07D471/04

    摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

    9E-15-(2-PYRROLIDIN-1-YL-ETHOXY)-7,12,25-TRIOXA-19,21,24-TRIAZA- TETRACYCLO[18.3.1.1(2,5).1(14)18)]HEXACOSA-1(24),2,4,9,14,16,18(26),20,22-NONAENE CITRATE SALT
    20.
    发明公开
    9E-15-(2-PYRROLIDIN-1-YL-ETHOXY)-7,12,25-TRIOXA-19,21,24-TRIAZA- TETRACYCLO[18.3.1.1(2,5).1(14)18)]HEXACOSA-1(24),2,4,9,14,16,18(26),20,22-NONAENE CITRATE SALT 有权
    9E-15-（2-吡咯烷-1-基 - 乙氧基）-7,12,25-三氧杂壬烷-19,21,24-三氮杂 - 四环[18.3.1.1（2,5）.1（14）18）] HEXACOSA-1（24），2,4,9,14,16,18（26），20,22-NONAENE CITRATE SALT

    公开(公告)号：EP2454266A1

    公开(公告)日：2012-05-23

    申请号：EP10737645.1

    申请日：2010-07-14

    申请人： S Bio Pte Ltd

    发明人： DYMOCK, Brian ,  LEE, Cheng Hsia, Angeline ,  WILLIAM, Anthony, Deodaunia

    IPC分类号： C07D498/12 ,  A61K31/519 ,  A61P35/00

    CPC分类号： C07D498/18

    摘要： The present invention relates to certain salts of a 9E-15-(2-pyrrolidin-1-yl-ethoxy)- 7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1 (2,5).1(14,18)]hexacosa-1 (24),2,4,9,14,16,18(26),20,22-nonaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

    摘要翻译： 本发明涉及9E-15-（2-吡咯烷-1-基 - 乙氧基）-7,12,25-三氧杂-19,21,24-三氮杂 - 四环[18.3.1.1（2,5 ）.1（14,18）]二十六碳-1（24），2,4,9,14,16,18（26），20,22-壬烯（化合物I），它们已被发现具有改进的性能。 具体地说，本发明涉及该化合物的柠檬酸盐。 本发明还涉及含有柠檬酸盐的药物组合物和使用该柠檬酸盐治疗某些医学病症的方法。