-
11.发明公开Method for making an immunogenic composition with Hoc fusion proteins and/or Soc fusion proteins 审中-公开一种用于通过使用融合蛋白Hoc和/或Soc融合蛋白的制备免疫原性组合物的方法
公开(公告)号：EP2196214A1
公开(公告)日：2010-06-16
申请号：EP10158774.9
申请日：2004-12-17
CPC分类号： C12N7/00 , A61K39/07 , A61K39/12 , A61K39/21 , A61K39/295 , A61K2039/5256 , A61K2039/55505 , A61K2039/57 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , A61K2039/645 , A61K2039/70 , C07K14/005 , C07K2299/00 , C07K2319/00 , C07K2319/21 , C07K2319/735 , C12N15/1037 , C12N15/86 , C12N2740/16034 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , C12N2795/10121 , C12N2795/10143 , C40B40/02
摘要： The invention relates to methods for making an immunogenic composition that employs Hoc and/or Soc fusion protein and T4 bacteriophage particle.
摘要翻译： 本发明涉及一种用于制备免疫原性组合物的方法没有采用Hoc和/或Soc融合蛋白和T4噬菌体粒子。
-
公开(公告)号：EP0567590A1
公开(公告)日：1993-11-03
申请号：EP92905377.0
申请日：1992-01-16
摘要： Agencement servant à inhiber les effets adverses, sur un organisme vivant, d'un champ ambiant variable dans le temps, qui présente une composante électrique égale ou inférieure à 5 Kv/M, et/ou une composante magnétique égale ou inférieure à 500 muT. Afin de conférer une protection à cet organisme, au moins l'un des paramètres caractéristiques dudit champ auquel est exposé cet organisme vivant, est modifié à des intervalles de temps inférieurs à 10 secondes.
-
公开(公告)号：EP0445239A4
公开(公告)日：1992-03-25
申请号：EP90909947
申请日：1990-06-14
IPC分类号： A61K31/00 , A61K31/505 , A61K31/513 , A61K31/52 , A61K31/70 , A61K45/06 , A61P33/02 , A61K
CPC分类号： A61K31/70 , A61K31/00 , A61K31/505 , A61K31/513 , A61K45/06 , Y10S514/885 , A61K2300/00
摘要： Anti-malarial compositions for prophylactic or therapeutic treatment of vertebrates exposed to malaria parasites are disclosed. These compositions comprise one or more pyrimidine analogue inhibitors of nucleic acid biosynthesis, e.g., 5-fluoro-orotic acid, alone or together with one or more "rescue" compounds, e.g., a normal pyrimidine base or nucleoside that can be used by the host vertebrate, but not by malaria-causing parasites, for nucleic acid biosynthesis. Also claimed are methods of prophylactic and therapeutic use of these compositions.
-
公开(公告)号：EP4371564A2
公开(公告)日：2024-05-22
申请号：EP24155130.8
申请日：2021-07-21
发明人： RAO, Venigalla B. , ZHU, Jingen
IPC分类号： A61K31/7088
CPC分类号： C12N15/86 , C12N2795/1014320130101 , C12N2795/1014220130101 , C12N15/102 , C12N2795/1012120130101 , C12N7/00 , C12N2310/2020170501
摘要： Described is an "artificial virus" (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
-
15.发明公开
公开(公告)号：EP4263811A1
公开(公告)日：2023-10-25
申请号：EP21905936.7
申请日：2021-12-14
发明人： RAO, Venigalla B. , ZHU, Jingen
IPC分类号： C12N7/00 , C12N9/22 , C07K14/005 , A61K39/215 , C12N15/70
-
16.发明公开
公开(公告)号：EP4240705A1
公开(公告)日：2023-09-13
申请号：EP21888768.5
申请日：2021-07-15
发明人： PEGG, Ian L. , GONG, Weiliang
IPC分类号： C04B28/06 , C04B12/00 , C04B14/28 , C04B22/00 , C04B40/00 , C04B103/10 , C04B103/32 , C04B103/30 , C04B111/62
-
公开(公告)号：EP4189096A1
公开(公告)日：2023-06-07
申请号：EP21850710.1
申请日：2021-07-21
发明人： RAO, Venigalla B. , ZHU, Jingen
IPC分类号： C12N15/86 , C12N15/113 , C12N9/22 , C12N15/10 , C12N15/88 , A61K48/00 , A61K31/7088
-
公开(公告)号：EP2389345B1
公开(公告)日：2020-03-04
申请号：EP10733839.4
申请日：2010-01-21
发明人： GONG, Weiliang , LUTZE, Werner , PEGG, Ian
IPC分类号： C04B18/08 , C04B28/24 , C04B22/00 , C04B18/14 , C04B103/44 , C04B103/14
-
公开(公告)号：EP2651846B1
公开(公告)日：2019-11-27
申请号：EP11848040.9
申请日：2011-12-16
发明人： GONG, Weiliang , LUTZE, Werner , PEGG, Ian
IPC分类号： C04B12/04
-
20.发明公开
公开(公告)号：EP2703491A1
公开(公告)日：2014-03-05
申请号：EP13194914.1
申请日：2011-04-08
发明人： Rao, Venigalla
IPC分类号： C12N15/63 , C12N7/01 , A61K31/7088 , A61K31/00 , A61K39/00 , A61K31/711 , C07K14/005 , C12N7/00 , C12N15/87 , C12N15/88
CPC分类号： C12N15/86 , A61K31/7088 , A61K31/711 , A61K47/48776 , A61K47/6901 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/87 , C12N15/88 , C12N2795/10042 , C12N2795/10122 , C12N2795/10142 , C12N2795/10152
摘要： Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
-
-
-
-
-
-
-
-
-
搜索结果
48 条记录 (耗时 0.018 秒)
