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264 条记录 (耗时 0.027 秒)

    METHOD AND MEANS FOR DIAGNOSING A HUMAN SEPSIS
    13.
    发明公开
    METHOD AND MEANS FOR DIAGNOSING A HUMAN SEPSIS 审中-公开

    公开(公告)号：EP3772651A1

    公开(公告)日：2021-02-10

    申请号：EP19190817.7

    申请日：2019-08-08

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： WEIß, Lukas ,  MANUKJAN, Georgi ,  WEISMANN, Dirk ,  SCHULZE, Harald

    IPC分类号： G01N33/68 ,  G01N33/49 ,  G01N33/86

    摘要： The present invention relates to a method of diagnosing a human sepsis. The present invention further relates to a kit for diagnosing a human sepsis. The present invention also relates to a point-of-care device for performing a method of diagnosing a human sepsis. The present invention also relates to a use of a kit and/or a point-of-care device for a method of diagnosing a human sepsis. The method comprises stimulating a platelet-specific (hem-)ITAM receptor by adding a (hem-)ITAM receptor agonistic agent to a blood sample of a patient, wherein said agonistic agent comprises CRP-XL and/or convulxin, and measuring a platelet function level.

    SYSTEM FOR THE ONE-SIDED GENERATION OF MAGNETIC FIELDS FOR THE MULTIDIMENSIONAL ENCODING OF MAGNETIC PARTICLES AND METHOD OF OPERATION THEREOF
    14.
    发明公开
    SYSTEM FOR THE ONE-SIDED GENERATION OF MAGNETIC FIELDS FOR THE MULTIDIMENSIONAL ENCODING OF MAGNETIC PARTICLES AND METHOD OF OPERATION THEREOF 审中-公开

    公开(公告)号：EP3702796A1

    公开(公告)日：2020-09-02

    申请号：EP19159986.9

    申请日：2019-02-28

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： Vogel, Patrick ,  Rückert, Martin

    IPC分类号： G01R33/12 ,  A61B5/05

    摘要： A system for measuring a presence of magnetic particles in a probe volume, said system comprising:
    - a coil assembly arranged around a central coil assembly axis for generating a rotating magnetic field distribution, said coil assembly comprising at least 3 circumferentially distributed coil assembly sectors, wherein said coil assembly sectors are arranged circumferentially with respect to said central coil assembly axis;
    - a current controller configured to generate in each of said coil assembly sectors a corresponding time varying current, said corresponding time varying current comprising a corresponding periodic modulation, wherein the periodic modulations of the coil assembly sectors have a same frequency and said periodic modulations are phase shifted between adjacent coil assembly sectors to generate a magnetic field rotating in a plane perpendicular to the coil assembly axis, said magnetic field rotating with a rotation frequency associated with the frequency of said periodic modulations,
    wherein said system is configured to measure said presence of magnetic particles in said probe volume with said coil assembly, wherein the coil assembly is such that the generated rotating magnetic field is spaced from the coil assembly along the central coil assembly axis in order for said probe volume to be spaced from said coil assembly along said coil assembly axis.

    METHOD FOR STATISTICALLY DETERMINING A QUANTIFICATION OF OLD AND NEW RNA
    16.
    发明公开
    METHOD FOR STATISTICALLY DETERMINING A QUANTIFICATION OF OLD AND NEW RNA 审中-公开

    公开(公告)号：EP3587586A1

    公开(公告)日：2020-01-01

    申请号：EP18179371.2

    申请日：2018-06-22

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： Erhard, Florian ,  Dölken, Lars

    IPC分类号： C12Q1/68 ,  G06F19/18 ,  C12Q1/6869 ,  G06F19/22 ,  G06F19/12

    摘要： The present invention provides a method for determining a quantification of old and new RNA for a gene, the method comprising:
    - obtaining reads from RNA fragments of a sample, wherein the RNA fragments comprise nucleotide substitutions caused by a metabolic marker,
    - determining statistics of nucleotide mismatches in the reads,
    - determining, based on the statistics of nucleotide mismatches, an error rate indicating a rate of nucleotide mismatches in old RNA and a conversion rate indicating a rate of nucleotide mismatches in new RNA, and
    - determining the quantification of old and newly synthesized RNA for the gene based on the error rate, the conversion rate and the statistics for the gene.

    SYSTEM AND METHOD FOR GENERATING A TRAVELING FIELD FREE LINE
    17.
    发明公开
    SYSTEM AND METHOD FOR GENERATING A TRAVELING FIELD FREE LINE 审中-公开

    公开(公告)号：EP3545835A1

    公开(公告)日：2019-10-02

    申请号：EP18165054.0

    申请日：2018-03-29

    申请人： Julius-Maximilians-Universität Würzburg Servicezentrum Forschung und Technologietransfer Patente und Lizenzen

    发明人： Vogel, Patrick ,  Rückert, Martin ,  Behr, Volker Christian

    IPC分类号： A61B5/05

    摘要： A system for generating a traveling field free line, traveling along a propagation direction different from the orientation of said traveling field free line, said system comprising at least a first and a second coil assembly, wherein said first coil assembly is configured for generating a first stationary field free line at a first location when a current is flowing in the first coil assembly and the second coil assembly is current free, and wherein said second coil assembly is configured for generating a second stationary field free line at a second location, when a current is flowing in the second coil assembly and the first coil assembly is current free, wherein said system further comprises a controller configured for driving the first and second coil assemblies with corresponding driving currents synchronized with each other such that at a first point in time, the first coil assembly's driving current amplitude is high and the second coil assembly's driving current amplitude is low, such that at said first point in time the traveling field free line is at or close to said first location, at a second point in time, the second coil assembly's driving current amplitude is high and the first coil assembly's driving current amplitude is low, such that at said second point in time the traveling field free line is at or close to said second location, and in a time interval between said first and second point in time, the amplitude of the first driving current in the first coil assembly decreases and the amplitude of the second driving current in the second coil assembly increases as compared to said first point in time such that said traveling field free line travels along the propagation direction from said first location towards said second location.

    METHOD AND APPARATUS FOR DETERMINING A MAGNETIC FIELD
    20.
    发明公开
    METHOD AND APPARATUS FOR DETERMINING A MAGNETIC FIELD 有权
    确定磁场的方法和设备

    公开(公告)号：EP3242139A1

    公开(公告)日：2017-11-08

    申请号：EP16168375.0

    申请日：2016-05-04

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： Münzhuber, Franz ,  Kleinlein, Johannes ,  Kießling, Tobias ,  Molenkamp, Laurens

    IPC分类号： G01R33/035 ,  G01R33/12

    CPC分类号： G01R33/035 ,  G01R33/1284

    摘要： The disclosure refers to a method for determining a magnetic field, comprising steps of: providing a magnetic sample (2), providing a probe (3) comprising diamond, wherein in the diamond a plurality of negatively charged nitrogen-vacancy centers are formed, scanning the probe with polarized light, wherein the probe (3) is irradiated with light emitted by a light source (4) and light reflected from the probe (3) is detected by a light detector (6), irradiating the probe (3) with polarized microwave radiation emitted by a microwave source (5) and detecting microwave radiation reflected from the probe (3) by a microwave detector (7), and evaluating the detected light and the detected microwave radiation. Also, an apparatus for determining a magnetic field is disclosed.

    摘要翻译： 本公开涉及用于确定磁场的方法，包括以下步骤：提供磁性样品（2）;提供包括金刚石的探针（3），其中在金刚石中形成多个带负电的氮空位中心;扫描 用光检测器（6）检测用光源（4）发射的光照射探针（3）并从探针（3）反射的光，用探针（3）照射探针（3） （5）发射的极化微波辐射并且通过微波检测器（7）检测从探针（3）反射的微波辐射，并评估检测到的光和检测到的微波辐射。 而且，公开了一种用于确定磁场的设备。