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    METHOD AND PROBE FOR MONITORING OXYGEN STATUS IN LIVE MAMMALIAN CELLS
    16.
    发明公开
    METHOD AND PROBE FOR MONITORING OXYGEN STATUS IN LIVE MAMMALIAN CELLS 有权
    一种用于确定哺乳动物细胞的活样品中的氧浓度的方法

    公开(公告)号：EP2630488A1

    公开(公告)日：2013-08-28

    申请号：EP10779731.8

    申请日：2010-10-22

    申请人： University College Cork, National University of Ireland, Cork

    发明人： PAPKOVSKY, Dmitri ,  FERCHER, Andreas ,  KLIMANT, Ingo ,  BORISOV, Sergey ,  ZHDANOV, Alexander

    IPC分类号： G01N33/50 ,  G01N33/84 ,  G01N33/58 ,  G01N31/22

    CPC分类号： G01N21/6486 ,  B82Y30/00 ,  G01N33/5005 ,  G01N33/587 ,  G01N33/84

    摘要： The invention is based on the use of photoluminescent probes for intracellular sensing of oxygen, especially assaying intracellular oxygen concentration. The photoluminescent probe comprises a suspension of polymeric particles having an average diameter in the 20nm to 100nm range, formed from an amphiphilic cationic co-polymer which is oriented in the formed particle to provide a hydrophobic core and a hydrophilic shell. The probe includes a hydrophobic oxygen-sensitive photoluminescent dye such as Pt-tetrakis (pentafluorophenyl) porphine, PtPFPP embedded in the hydrophobic core of the particle, and the co-polymer includes quaternary ammonium groups which provide hydrophilic and cationic character to the particle shell. The photoluminescent probe, which in use is provided in the form of an aqueous suspension of probe, is incubated with live mammalian cells in a suitable growth medium for a period of time to allow the probe particles passively load into the cells. Oxygen can then be sensed by detecting a photoluminescent signal of the photoluminescent probe, which can be correlated with oxygen status, for example oxygen concentration or changes in oxygen concentration/levels, using existing techniques.

    Mesoporous silica microparticles
    17.
    发明公开
    Mesoporous silica microparticles 审中-公开
    介孔二氧化硅微粒

    公开(公告)号：EP2615064A8

    公开(公告)日：2013-08-28

    申请号：EP13154419.9

    申请日：2008-07-14

    申请人： University College Cork - National University of Ireland, Cork

    发明人： Holmes, Justin ,  Morris, Michael ,  Hanrahan, John ,  Keane, Donal ,  Copley, Mark

    IPC分类号： C01B33/12 ,  C01B37/02

    CPC分类号： C01B37/02 ,  C01B33/12 ,  Y10T428/2982

    摘要： Mesoporous silica microparticles with an average diameter of up to about 50 µm synthesized by a method comprising: preparing a sol from an ammonium catalysed hydrolysis and condensation reaction of a pre-sol solution comprising a silica precursor and a structure directing agent dissolved in a mixed solvent system comprising an alcohol and water; hydrothermally treating the particles to increase the pore size; treating the particles to remove residual structure directing agent; and further increasing the pore size using controlled dissolution.

    摘要翻译： 通过包括以下步骤的方法合成平均直径高达约50μm的介孔二氧化硅微粒：由溶解在混合溶剂中的包含二氧化硅前体和结构导向剂的前溶胶溶液的铵催化的水解和缩合反应制备溶胶 包含醇和水的系统; 水热处理颗粒以增加孔径; 处理颗粒以除去残留的结构导向剂; 并使用受控溶解进一步增加孔径。

    Optical amplifier system and method
    18.
    发明公开
    Optical amplifier system and method 审中-公开
    OptischesVerstärkersystemund -verfahren

    公开(公告)号：EP2330760A1

    公开(公告)日：2011-06-08

    申请号：EP09177865.4

    申请日：2009-12-03

    申请人： University College Cork-National University of Ireland, Cork ,  Chalmers University of Technology ,  National & Kapodistrian University of Athens ,  University of Southhampton

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： H04B10/17

    CPC分类号： H01S3/10007 ,  H04B10/291 ,  H04B10/2914

    摘要： The invention provides a system for use in an optical communication network to reduce noise comprising means for tapping a low noise signal from said network and a phase sensitive amplifier (PSA) for conditioning said tapped signal. A laser source provides phase locked reference signals to generate at least one pump signal, wherein the at least one pump signal provides correct phase alignment for optimum PSA operation. The invention makes use of injection locked and/or phase locked laser sources in conjunction with low power input tap couplers, or post/mid amplification taps to provide the required phase locked reference signals without degrading the input loss or noise. The use of injection/phase locked local lasers suppresses the detrimental impact of the low tapped power or added noise in the generation of the required pump signals.

    摘要翻译： 本发明提供了一种用于光通信网络以减少噪声的系统，包括用于从所述网络窃取低噪声信号的装置和用于调节所述抽头信号的相位敏感放大器（PSA）。 激光源提供锁相参考信号以产生至少一个泵浦信号，其中所述至少一个泵浦信号提供用于最佳PSA操作的正确相位对准。 本发明利用注入锁定和/或锁相激光源结合低功率输入抽头耦合器或后/中间放大抽头来提供所需的锁相参考信号而不降低输入损耗或噪声。 使用注入/锁相局部激光器可以抑制低抽头功率或附加噪声对产生所需泵浦信号的不利影响。