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公开(公告)号：EP4357493A2
公开(公告)日：2024-04-24
申请号：EP24158974.6
申请日：2014-06-26
申请人： 10X Genomics, Inc.
发明人： HINDSON, Benjamin , HINDSON, Christopher , SCHNALL-LEVIN, Michael , NESS, Kevin , JAROSZ, Mirna , MASQUELIER, Donald , SAXONOV, Serge , MERRILL, Landon , PRICE, Andrew , HARDENBOL, Paul , LI, Yuan
IPC分类号： C40B20/00
CPC分类号： C12Q1/6813 , C12Q1/6869 , C12Q1/6876
摘要： This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provided herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
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公开(公告)号：EP4144861A1
公开(公告)日：2023-03-08
申请号：EP22181577.2
申请日：2016-12-02
申请人： 10X Genomics, Inc.
IPC分类号： C12Q1/68
摘要： The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
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公开(公告)号：EP3862435A1
公开(公告)日：2021-08-11
申请号：EP20196181.0
申请日：2014-02-07
申请人： 10X Genomics, Inc.
发明人： HINDSON, Benjamin , JAROSZ, Mirna , HARDENBOL, Paul , SCHNALL-LEVIN, Michael , NESS, Kevin , SAXONOV, Serge
IPC分类号： C12P19/34
摘要： The present disclosure provides compositions, methods, systems and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing. In some cases, this disclosure provides methods for the generation of polynucleotide barcode libraries, and for the attachment of such polynucleotides to target polynucleotides.
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公开(公告)号：EP2954104B1
公开(公告)日：2020-09-16
申请号：EP14749595.6
申请日：2014-02-07
申请人： 10X Genomics, Inc.
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公开(公告)号：EP3467160A1
公开(公告)日：2019-04-10
申请号：EP18189200.1
申请日：2014-06-26
申请人： 10X Genomics, Inc.
发明人： HINDSON, Benjamin , HINDSON, Christopher , SCHNALL-LEVIN, Michael , NESS, Kevin , JAROSZ, Mirna , MASQUELIER, Donald , SAXONOV, Serge , MERRILL, Landon , PRICE, Andrew , HARDENBOL, Paul , LI, Yuan
摘要： This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. Often, the beads provided herein are degradable. For example, they may contain disulfide bonds that are susceptible to reducing agents. The methods provided herein include methods of making libraries of barcoded beads as well as methods of combining the beads with a sample, such as by using a microfluidic device.
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公开(公告)号：EP3384048A1
公开(公告)日：2018-10-10
申请号：EP16822294.1
申请日：2016-12-02
申请人： 10X Genomics, Inc.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6809 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869 , C12Q2521/501 , C12Q2523/101 , C12Q2525/155 , C12Q2525/191 , C12Q2535/122 , C12Q2543/101 , C12Q2563/149 , C12Q2563/159 , C12Q2563/179 , C12Q2565/631
摘要： The present invention is directed to methods, compositions and systems for analyzing sequence information while retaining structural and molecular context of that sequence information.
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公开(公告)号：EP3161162A1
公开(公告)日：2017-05-03
申请号：EP15812053.5
申请日：2015-06-26
申请人： 10X Genomics, Inc.
发明人： SCHNALL-LEVIN, Michael , JAROSZ, Mirna , HINDSON, Christopher , NESS, Kevin , SAXONOV, Serge , HINDSON, Benjamin , ZHENG, Grace, X.Y. , MARKS, Patrick , STUELPNAGEL, John
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/156 , G06F19/22 , C12Q2535/122 , C12Q2537/16 , C12Q2563/159 , C12Q2565/629
摘要： The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.
摘要翻译： 本公开涉及用于单体型定相和拷贝数变异测定的方法，组合物和系统。 本公开内容包括用于将包含珠子的条形码与多个单独分区中的样品组合的方法和系统，以及处理，测序和分析条形码化样品的方法。
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公开(公告)号：EP2954104A1
公开(公告)日：2015-12-16
申请号：EP14749595.6
申请日：2014-02-07
申请人： 10X Genomics, Inc.
发明人： HINDSON, Benjamin , JAROSZ, Mirna , HARDENBOL, Paul , SCHNALL-LEVIN, Michael , NESS, Kevin , SAXONOV, Serge
摘要： The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.
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