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11.发明公开HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权杂环衍生物及其前列腺素D2受体调节剂
公开(公告)号：EP2794563A1
公开(公告)日：2014-10-29
申请号：EP12823031.5
申请日：2012-12-20
IPC分类号： C07D209/44 , C07D217/06 , C07D223/06 , C07D223/16 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06 , C07D417/06 , A61K31/47
CPC分类号： C07D417/06 , C07D209/44 , C07D217/06 , C07D223/06 , C07D223/16 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/06
摘要： The present invention relates to phenyl-substituted heterocyclyl derivatives of the formula (I) wherein Z, n, m, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 and R
8 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D
2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.-
公开(公告)号：EP2521715B1
公开(公告)日：2014-06-25
申请号：EP11702702.9
申请日：2011-01-04
IPC分类号： C07D213/56 , C07D213/64 , C07D295/185 , A61K31/495 , A61K31/496 , A61P33/02 , A61P33/06
CPC分类号： C07D213/56 , C07D213/64 , C07D295/185
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13.发明公开7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权7-（杂芳基 - 氨基）-6,7,8,9-四氢吡啶并[1,2-a]吲哚乙酸衍生物及其作为前列腺素D2受体调节剂
公开(公告)号：EP2697223A1
公开(公告)日：2014-02-19
申请号：EP12722194.3
申请日：2012-04-13
发明人： AISSAOUI, Hamed , BOSS, Christoph , GABILLET, Jerome , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
IPC分类号： C07D471/04 , A61K31/437 , A61P37/08
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives of the formula (I), wherein R
1 , R
2 , R
3 and R
4 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D
2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.-
公开(公告)号：EP2288603A1
公开(公告)日：2011-03-02
申请号：EP09762141.1
申请日：2009-06-10
发明人： AISSAOUI, Hamed , BOSS, Christoph , BROTSCHI, Christine , GATFIELD, John , KOBERSTEIN, Ralf , SIEGRIST, Romain , SIFFERLEN, Thierry , WILLIAMS, Jodi T.
IPC分类号： C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , A61P25/00 , A61P3/10
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R
1 , R
2 and R
3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.-
15.发明公开AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 审中-公开阿尔茨海默氏病在德国维尔登斯ALS PROSTAGLANDIN-D2-REZEPTORMODULATOREN
公开(公告)号：EP3119780A1
公开(公告)日：2017-01-25
申请号：EP15714032.8
申请日：2015-03-17
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , A61K31/435
摘要： wherein R1 and R2 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 其中R 1和R 2如在描述中所述及其作为前列腺素受体调节剂，最特别地作为前列腺素D 2受体调节剂在治疗各种前列腺素介导的疾病和病症中的用途，含有这些化合物的药物组合物及其制备方法 。
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16.发明授权1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权1-苯基 - 取代的杂环衍生物及其前列腺素D2受体的调节剂
公开(公告)号：EP2590944B1
公开(公告)日：2015-09-30
申请号：EP11752340.7
申请日：2011-07-04
发明人： AISSAOUI, Hamed , BOSS, Christoph , POTHIER, Julien , RICHARD-BILDSTEIN, Sylvia , RISCH, Philippe , SIEGRIST, Romain , FRETZ, Heinz
IPC分类号： C07D209/44 , C07D217/16 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , A61K31/4035 , A61K31/472
CPC分类号： C07D487/04 , A61K31/4035 , A61K31/472 , C07D209/44 , C07D217/16 , C07D217/26 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D471/04
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17.发明公开3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权3-（杂芳基 - 氨基）-1,2,3,4-四氢-9H-咔唑衍生物及其前列腺素D2受体调节剂
公开(公告)号：EP2558447A1
公开(公告)日：2013-02-20
申请号：EP11715042.5
申请日：2011-03-21
发明人： AISSAOUI, Hamed , FRETZ, Heinz , HAZEMANN, Julien , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
IPC分类号： C07D209/88 , A61K31/403 , A61P11/06
CPC分类号： C07D209/88
摘要： The present invention relates to 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), wherein R
1 , R
2 and R
3 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D
2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.-
18.发明公开
公开(公告)号：EP2334643A1
公开(公告)日：2011-06-22
申请号：EP09749189.8
申请日：2009-10-13
发明人： AISSAOUI, Hamed , BOSS, Christoph , BROTSCHI, Christine , KOBERSTEIN, Ralf , SIEGRIST, Romain , SIFFERLEN, Thierry , TRACHSEL, Daniel , WILLIAMS, Jodi T.
IPC分类号： C07D213/63 , C07D235/04 , C07D237/28 , C07D239/34 , C07D241/18 , C07D263/36 , C07D277/30 , C07D285/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14 , A61K31/403 , A61K31/4184
CPC分类号： C07D277/30 , C07D213/63 , C07D235/04 , C07D237/28 , C07D239/34 , C07D241/18 , C07D263/36 , C07D285/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R
1 , R
2 and R
3 are as described in the application, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.-
19.发明公开AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权阿尔茨海默氏病在德国维尔登斯ALS PROSTAGLANDIN-D2-REZEPTORMODULATOREN
公开(公告)号：EP3119779A1
公开(公告)日：2017-01-25
申请号：EP15714030.2
申请日：2015-03-16
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： wherein R1 and R2 are as described in the description, and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
摘要翻译： 其中R1和R2如描述中所述，以及它们作为前列腺素受体调节剂，最特别地作为前列腺素D2受体调节剂在治疗各种前列腺素介导的疾病和病症中的用途，含有这些化合物的药物组合物及其用于 制备。
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20.发明授权7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS 有权7-（杂芳基 - 氨基）-6,7,8,9-四氢吡啶并[1,2-a]吲哚乙酸衍生物及其作为前列腺素D2受体调节剂
公开(公告)号：EP2697223B1
公开(公告)日：2016-07-13
申请号：EP12722194.3
申请日：2012-04-13
发明人： AISSAOUI, Hamed , BOSS, Christoph , GABILLET, Jerome , RICHARD-BILDSTEIN, Sylvia , SIEGRIST, Romain
IPC分类号： C07D471/04 , A61K31/437 , A61P37/08
CPC分类号： C07D471/04 , A61K31/437
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