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11.发明授权INDAZOLE AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS 有权吲唑和PYRAZOLOPYRIDIN-化合物作为CCR1受体拮抗剂
公开(公告)号：EP2491028B1
公开(公告)日：2013-12-11
申请号：EP10768356.7
申请日：2010-10-19
IPC分类号： C07D401/12 , C07D471/04 , A61K31/437 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/437 , A61K31/4439 , A61K31/5377 , C07D213/62 , C07D471/04
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12.发明公开INDAZOLE AND PYRAZOLOPYRIDINE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS 有权吲唑和PYRAZOLOPYRIDIN-化合物作为CCR1受体拮抗剂
公开(公告)号：EP2491028A1
公开(公告)日：2012-08-29
申请号：EP10768356.7
申请日：2010-10-19
IPC分类号： C07D401/12 , C07D471/04 , A61K31/437 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/437 , A61K31/4439 , A61K31/5377 , C07D213/62 , C07D471/04
摘要： Diclosed are CCRl receptor antagonists of the formula (I), wherein X is nitrogen or, C-R
2 ; Ar
1 is carbocycle, heteroaryl or heterocyclyl each optionally substituted by one to three R
a ; Ar
2 is carbocycle, heteroaryl or heterocyclyl, each optionally substituted by one to three R
b ; Cyclic G is carbocycle, or heterocyclyl each optionally substituted by one to two R
8 ; R
1 is hydrogen, C
1-6 alkyl or C
1-6 alkoxyC
1-6 alkyl. Also disclosed are compositions, methods of making and using compounds of the formula (I).-
13.发明授权GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472B1
公开(公告)日：2012-01-18
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
公开(公告)号：EP2285783A1
公开(公告)日：2011-02-23
申请号：EP09739468.8
申请日：2009-04-23
发明人： DISALVO, Darren , KUZMICH, Daniel , MAO, Can , RAZAVI, Hossein , SARKO, Christopher , SWINAMER, Alan, David , THOMSON, David , ZHANG, Qiang
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P19/02 , A61P25/28
CPC分类号： C07D231/56 , C07D401/12
摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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15.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素类似物，其制造，药物组合物及其使用方法
公开(公告)号：EP2136811A1
公开(公告)日：2009-12-30
申请号：EP08745327.0
申请日：2008-04-09
IPC分类号： A61K31/535
CPC分类号： C07C323/49 , C07C311/17 , C07C311/18 , C07C311/41 , C07C2602/08 , C07C2602/10
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 如定义在（i）其中R1，R2，R3，R4，R5，R6，X，R7，R8和式I的化合物，或其互变异构体，前药，溶剂化物，或它们的盐; 药物组合物含有受试化合物，并调节糖皮质激素受体功能的方法和治疗疾病状态或由糖皮质激素受体功能中使用这些化合物的患者介导的或特征为炎性，过敏性或增生性过程病症的方法。
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16.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：EP2102170A2
公开(公告)日：2009-09-23
申请号：EP07864855.7
申请日：2007-11-29
IPC分类号： C07D231/56 , C07D401/14 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , A61K31/437 , A61K31/416 , A61P5/44 , A61P5/46
CPC分类号： C07D417/06 , C07D231/56 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D407/14 , C07D409/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： Compounds of Formula (IA), and Formula (IB), wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，A，B，C，D，E，G，X，Y和Z如本文所定义的式（IA）和式（IB）化合物或其互变异构体，前药，溶剂化物 或其盐; 含有这些化合物的药物组合物以及调节糖皮质激素受体功能的方法以及使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。
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