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公开(公告)号：EP2655371A1
公开(公告)日：2013-10-30
申请号：EP11808470.6
申请日：2011-12-16
发明人： BETAGERI, Rajashekhar , COOK, Brian, Nicholas , DISALVO, Darren , HARCKEN, Christian , KUZMICH, Daniel , LIU, Pingrong , LORD, John , MAO, Can , RAZAVI, Hossein
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4162 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译： 公开了式（I）化合物，用于治疗通过CCR1活性介导或维持的多种疾病和病症，包括自身免疫性疾病如类风湿性关节炎和多发性硬化症。 还公开了制造方法和使用方法。
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公开(公告)号：EP2346868A1
公开(公告)日：2011-07-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译： 公开了式（I）化合物，用于治疗通过CCR1活性介导或维持的多种疾病和病症，包括自身免疫性疾病如类风湿性关节炎和多发性硬化症。 还公开了制造方法和使用方法。
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3.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 有权GLUCOCORTICOIDMIMETIKA，用于生产药物组合物的方法及其用途
公开(公告)号：EP2300472A1
公开(公告)日：2011-03-30
申请号：EP09759298.4
申请日：2009-06-03
发明人： BOEHRINGER INGELHEIM PHARMA GMBH&CO. KG , BETAGERI, Rajashekhar , BOSANAC, Todd , BURKE, Michael, Jason , HARCKEN, Christian , KIM, Soojin , KUZMICH, Daniel , LEE, Thomas, Wai-ho , LI, Zhibin , LIU, Pingrong , LORD, John , RAZAVI, Hossein , REEVES, Jonathan, Timothy , THOMSON, David
IPC分类号： C07D471/04 , A61K31/437 , A61P5/44 , A61P5/46
CPC分类号： C07D471/04
摘要： Compounds of Formula I wherein R
1 , R
2 , X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
4.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素类似物，其制造，药物组合物及其使用方法
公开(公告)号：EP2183217A2
公开(公告)日：2010-05-12
申请号：EP08826655.6
申请日：2008-07-21
发明人： KUZMICH, Daniel , REGAN, John R.
IPC分类号： C07D209/10 , C07D209/42 , C07D211/04 , C07D215/06 , C07D217/04 , C07D217/24 , C07D231/12 , C07D235/06 , C07D307/79 , C07D471/04 , C07D295/13 , C07D215/227 , C07D215/233
CPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/42 , C07D215/06 , C07D215/18 , C07D215/48
摘要： Compounds of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , and R
7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.-
公开(公告)号：EP2346868B1
公开(公告)日：2016-01-27
申请号：EP09792818.8
申请日：2009-09-22
发明人： COOK, Brian Nicholas , DISALVO, Darren , FANDRICK, Daniel Robert , HARCKEN, Christian , KUZMICH, Daniel , LEE, Thomas Wai-Ho , LIU, Pingrong , LORD, John , MAO, Can , NEU, Jochen , RAUDENBUSH, Brian Christopher , RAZAVI, Hossein , REEVES, Jonathan Timothy , SONG, Jinhua, J. , SWINAMER, Alan, David , TAN, Zhulin
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
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公开(公告)号：EP2493875B1
公开(公告)日：2014-08-06
申请号：EP10773474.1
申请日：2010-10-21
IPC分类号： C07D401/12 , C07D471/04 , C07D209/42 , A61K31/46 , A61P19/02 , A61P25/28
CPC分类号： C07D401/12 , C07D209/42 , C07D471/04
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公开(公告)号：EP2493875A1
公开(公告)日：2012-09-05
申请号：EP10773474.1
申请日：2010-10-21
IPC分类号： C07D401/12 , C07D471/04 , C07D209/42 , A61K31/46 , A61P19/02 , A61P25/28
CPC分类号： C07D401/12 , C07D209/42 , C07D471/04
摘要： Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1-R3, X and L are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).
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8.发明公开GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：EP2136634A1
公开(公告)日：2009-12-30
申请号：EP08745203.3
申请日：2008-04-07
发明人： RAZAVI, Hossein , KUZMICH, Daniel
CPC分类号： C07D209/08 , C07D209/48 , C07D213/70 , C07D213/84 , C07D215/20 , C07D215/233 , C07D215/24 , C07D215/36 , C07D215/40 , C07D217/02 , C07D219/06 , C07D233/46 , C07D235/26 , C07D239/38 , C07D277/64 , C07D307/83 , C07D311/14 , C07D319/18 , C07D321/10 , C07D333/54 , C07D405/04 , C07D409/04
摘要： Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, R7, and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，X，R 7和R 8如本文所定义的式（I）化合物或其互变异构体，前药，溶剂化物或盐; 含有这些化合物的药物组合物以及调节糖皮质激素受体功能的方法以及使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。
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公开(公告)号：EP2655371B1
公开(公告)日：2015-02-25
申请号：EP11808470.6
申请日：2011-12-16
发明人： BETAGERI, Rajashekhar , COOK, Brian, Nicholas , DISALVO, Darren , HARCKEN, Christian , KUZMICH, Daniel , LIU, Pingrong , LORD, John , MAO, Can , RAZAVI, Hossein
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4162 , A61P29/00
CPC分类号： C07D471/04 , C07D487/04
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公开(公告)号：EP2285783B1
公开(公告)日：2014-05-21
申请号：EP09739468.8
申请日：2009-04-23
发明人： DISALVO, Darren , KUZMICH, Daniel , MAO, Can , RAZAVI, Hossein , SARKO, Christopher , SWINAMER, Alan, David , THOMSON, David , ZHANG, Qiang
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P19/02 , A61P25/28
CPC分类号： C07D231/56 , C07D401/12
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