利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

23 条记录 (耗时 0.023 秒)

    6-CYCLOALKYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A INHIBITORS
    11.
    发明公开
    6-CYCLOALKYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A INHIBITORS 有权
    6-环丙基-1,5-二氢吡喃并[3,4-D]吡啶二酮-4-酮衍生物在IHRE VERWENDUNG ALS PDE9A INHIBITOREN

    公开(公告)号：EP2603511A1

    公开(公告)日：2013-06-19

    申请号：EP11740949.0

    申请日：2011-08-09

    申请人： Boehringer Ingelheim International GmbH

    发明人： HEINE, Niklas ,  EICKMEIER, Christian ,  FERRARA, Marco ,  GIOVANNINI, Riccardo ,  ROSENBROCK, Holger ,  SCHAENZLE, Gerhard

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

    CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I) wherein R
    1 is a 5 or 6 membered aromatic heteroaryl-group, R
    2 is an optional substituent, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, m= 1 or 2 and n is 0, 1 or 2. The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimers disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.

    摘要翻译： 具有PDE9抑制性质的式（I）的新型6-环烷基 - 吡唑并嘧啶酮，其中R 1为5或6元芳族杂芳基，R 2为任选的取代基，D为任选取代的环戊基，环己基，四氢呋喃基，四氢吡喃基或 2-，3-或4-吡啶基，m = 1或2，n为0,1或2.新化合物可用作药物，特别是用于治疗有关感知，集中，学习或记忆缺陷的病症 。 这些病症可能与阿尔茨海默病，精神分裂症和其他疾病有关。 新化合物可用于治疗与这些疾病相关的认知障碍。

    6-CYCLOALKYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A INHIBITORS
    14.
    发明公开
    6-CYCLOALKYL-1, 5-DIHYDRO-PYRAZOLO [3, 4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A INHIBITORS 审中-公开
    6-环丙基-1,5-二氢吡喃并[3,4-D]吡啶二酮-4-酮在DEREN VERWENDUNG ALS PDE9A-HEMMER

    公开(公告)号：EP3053924A1

    公开(公告)日：2016-08-10

    申请号：EP16152675.1

    申请日：2011-08-09

    申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH

    发明人： HEINE, Niklas ,  EICKMEIER, Christian ,  FERRARA, Marco ,  GIOVANNINI, Riccardo ,  ROSENBROCK, Holger ,  SCHAENZLE, Gerhard

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

    CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

    摘要： Novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I) with PDE9 inhibiting properties,

    wherein R 1 is a 5 or 6 membered aromatic heteroaryl-group, R 2 is an optional substituent, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, m= 1 or 2 and n is 0, 1 or 2.
    The new compounds can be used as medicaments, in particular for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds can be used in the treatment of cognitive impairment associated with such diseases.

    摘要翻译： 具有PDE9抑制性质的式（I）的新型6-环烷基 - 吡唑并嘧啶酮，其中R 1是5或6元芳族杂芳基，R 2是任选的取代基，D是任选取代的环戊基，环己基，四氢呋喃基，四氢吡喃基或 2-，3-或4-吡啶基，m = 1或2，n为0,1或2.新化合物可用作药物，特别是用于治疗有关感知，集中，学习或记忆缺陷的病症 。 这些病症可能与阿尔茨海默病，精神分裂症和其他疾病有关。 新化合物可用于治疗与这些疾病相关的认知障碍。

    6 - CYCLOBUTYL - 1, 5 - DIHYDRO - PYRAZOLO [3, 4-D]PYRIMIDIN- 4 - ONE DERIVATIVES THEIR USE AS PDE9A INHIBITORS
    15.
    发明公开
    6 - CYCLOBUTYL - 1, 5 - DIHYDRO - PYRAZOLO [3, 4-D]PYRIMIDIN- 4 - ONE DERIVATIVES THEIR USE AS PDE9A INHIBITORS 有权
    6-环丁基-1,5-二氢吡唑并[3,4-d]嘧啶-4-酮及其作为PDE9抑制剂

    公开(公告)号：EP2675807A1

    公开(公告)日：2013-12-25

    申请号：EP12705246.2

    申请日：2012-02-13

    申请人： Boehringer Ingelheim International GmbH

    发明人： HEINE, Niklas ,  GIOVANNINI, Riccardo ,  FERRARA, Marco

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28

    CPC分类号： C07D487/04

    摘要： The invention relates to novel pyrazolopyrimidinones according to formula (I) wherein R1 is a pyridyl or pyrimidinyl group and D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl. The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.