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公开(公告)号：EP3489233A1
公开(公告)日：2019-05-29
申请号：EP17830503.3
申请日：2017-07-21
发明人： YAO, Yuanshan , CHEN, Bin , CHEN, Yuan , LI, Ao , XU, Ran , HUANG, Zhensheng , TIAN, Dongdong , LI, Hongwei , YANG, Chengshuai , LI, Jian , CHEN, Shuhui
IPC分类号： C07D409/04 , C07D409/14 , C07D409/06 , C07D495/04 , A61K31/4439 , A61K31/405 , A61K31/4365 , A61P43/00
摘要： The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.
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公开(公告)号：EP3248968A1
公开(公告)日：2017-11-29
申请号：EP16739808.0
申请日：2016-01-22
发明人： CHEN, Shuhui , DING, Charles Z. , YAN, Xiaobing , HUANG, Wei , HU, Guoping , LI, Jian , ZHANG, Xiquan , YANG, Ling , XU, Hongjiang
IPC分类号： C07D413/04 , C07D487/08 , C07D495/04 , C07D513/04 , C07D471/04 , C07D417/04 , C07D413/14 , A61K31/4725 , A61K31/422 , A61K31/4365 , A61K31/437
CPC分类号： C07D413/04 , A61K31/422 , A61K31/4365 , A61K31/437 , A61K31/4725 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04 , Y02P20/55
摘要： The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.
摘要翻译： 本发明涉及作为HSP90抑制剂的间苯二酚衍生物或其药学上可接受的盐的式（I）所示的化合物。 本发明中的化合物具有抑制热休克蛋白HSP90的活性。 因此，本发明中的化合物用于治疗增殖性疾病如癌症和神经退行性疾病。 本发明进一步提供了用于包含所述化合物的药物组合物的化合物和制备方法，治疗疾病的方法以及包含所述化合物的药物组合物。
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公开(公告)号：EP4417613A1
公开(公告)日：2024-08-21
申请号：EP22880368.0
申请日：2022-10-13
发明人： LUO, Yunfu , ZHANG, Guoli , LI, Shaolong , GE, Weizhi , CHEN, Shuhui
IPC分类号： C07D519/00 , C07D487/04 , C07D487/06 , C07D498/14 , C07D498/16 , A61K31/519 , A61P9/00
CPC分类号： A61K31/519 , A61P9/00 , C07D487/04 , C07D487/06 , C07D498/16 , C07D498/14 , C07D519/00
摘要： A pyrimidine tricyclic derivative and a pharmaceutical application thereof. Specifically disclosed are a compound as represented by formula (I), a stereoisomer thereof, and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4190790A1
公开(公告)日：2023-06-07
申请号：EP21849829.3
申请日：2021-07-30
发明人： HU, Yanbin , LI, Gang , HU, Lihong , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D498/06 , C07D267/02 , A61K31/55 , A61P35/00
摘要： Disclosed is a type of indolo heptamyl oxime analog crystalline form as a PARP inhibitor and a method for preparing the same, specifically relating to a crystalline form of a compound of formula (I) and a method for preparing the same.
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公开(公告)号：EP4006036A1
公开(公告)日：2022-06-01
申请号：EP20854855.2
申请日：2020-08-20
发明人： LU, Lun , LI, Gang , HU, Lihong , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D493/14 , C07D493/22 , C07D487/22 , C07D491/22 , A61K31/519 , A61K31/5377 , A61P35/00
摘要： A tetracyclic compound as a Cdc7 inhibitor. Specifically disclosed is a compound represented by formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof. (I)
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公开(公告)号：EP3712162A1
公开(公告)日：2020-09-23
申请号：EP18875727.2
申请日：2018-11-13
发明人： LIU, Yingchun , XU, Zhaobing , HU, Lihong , DING, Charles Z. , ZHU, Xingxun , HU, Guoping , LI, Jian , CHEN, Shuhui
IPC分类号： C07K5/06 , C07D403/06 , A61K31/4045 , A61P35/00
摘要： Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer.
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公开(公告)号：EP4357336A1
公开(公告)日：2024-04-24
申请号：EP22824215.2
申请日：2022-06-14
发明人： WU, Lingyun , XIAO, Zheming , CHEN, Yi , XU, Xiongbin , XIA, Wei , GUO, Tangyang , CAO, Lan , CHAN, Chi-Chung , LI, Qiu , LI, Jian , CHEN, Shuhui
IPC分类号： C07D265/36 , A61K31/538 , A61P13/12
CPC分类号： C07D265/36 , A61K31/538 , A61P13/12
摘要： A class of benzoxazinone derivatives and a preparation method therefor, specifically related to a compound shown in formula (II), or a stereoisomer or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP4166144A1
公开(公告)日：2023-04-19
申请号：EP21823093.6
申请日：2021-06-07
发明人： AN, Ke , SUN, Fei , DING, Charles Z. , CHEN, Shuhui
IPC分类号： A61K31/713 , A61P31/20 , C12N15/113
摘要： Provided are a double-stranded siRNA analogue embedded with a ribavirin derivative, a conjugate containing same, and a salt and the use thereof. The provided double-stranded siRNA analogue, the conjugate containing same and the salt thereof can effectively inhibit multiple viral indicators such as hepatitis B virus DNA, pgRNA, S antigen, and E antigen, which provide an effective and feasible method for treating hepatitis B.
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公开(公告)号：EP3919495A1
公开(公告)日：2021-12-08
申请号：EP20749766.0
申请日：2020-02-03
发明人： HU, Yanbin , LI, Gang , SUN, Fei , CHI, Zhigang , LUO, Jin , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D471/06 , C07D487/06 , A61K31/55 , A61P35/00
摘要： Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP3875451A1
公开(公告)日：2021-09-08
申请号：EP19873359.4
申请日：2019-10-18
发明人： SUN, Fei , CAI, Zhe , DING, Charles Z. , CHEN, Shuhui
IPC分类号： C07D239/95 , C07D401/12 , C07D413/04 , C07D413/14 , C07D475/04 , A61K31/517 , A61P31/00 , A61P31/18 , A61P31/20 , A61P31/14
摘要： The present invention relates to a structurally novel TLR8 (Toll-like receptor 8) agonist and, in particular, to a compound thereof of formula (I), a pharmaceutically acceptable salt and an isomer thereof.
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