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11.发明公开UTILISATION DES ACIDES QUINIQUE, SHIKIMIQUE ET DE LEURS DERIVES POUR LA PREPARATION DE LIGANDS DU RECEPTEUR DU MANNOSE 审中-公开中国和莽草酸及其衍生物为配体甘露糖受体的制备中使用
公开(公告)号：EP1200462A2
公开(公告)日：2002-05-02
申请号：EP00956573.0
申请日：2000-07-28
发明人： GRANDJEAN, Cyrille , MELNYK, Oleg , GRAS-MASSE, Hélène , ANGYALOSI, Gerhild , ROMMENS, Corinne , AURIAULT, Claude
IPC分类号： C07K14/00 , C07K7/02 , C07K5/023 , C07K5/037 , A61K38/04 , A61K38/16 , G01N33/68 , A61K31/19
CPC分类号： C07K5/0202 , C07K5/0215 , C07K7/02 , C07K14/001
摘要： The invention concerns the use of quinic, shimic acids and their derivatives for preparing mannose receptor ligands, the resulting ligands and the uses of said ligands, in particular for preparing medicines and, more particularly for preparing vaccines and medicines for vectoring an active principle to target cells expressing the mannose receptor or a receptor related thereto, for transfecting DNA and RNA sequences and numerous other uses in gene therapy, and for preparing laboratory reagents, in particular diagnostic reagents.
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12.发明授权LIPOPEPTIDES INDUCTEURS DE CYTOTOXICITE T LYMPHOCYTAIRE PORTANT AU MOINS UN EPITOPE T AUXILIAIRE, ET LEURS UTILISATIONS POUR LA VACCINATION 有权脂肽细胞毒性T淋巴细胞ANSWER引诱，与至少一个表位T辅助细胞，及其作为疫苗
公开(公告)号：EP1068226B1
公开(公告)日：2005-04-20
申请号：EP99911884.7
申请日：1999-04-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： LE GAL, Frédérique, Anne , GUILLET, Jean, Gérard , GAHERY-SEGARD, Hanne , GRAS-MASSE, Hélène , MELNYK, Oleg , TARTAR, André
IPC分类号： C07K14/025 , C07K14/16 , A61K39/295 , A61K47/48
CPC分类号： C07K14/005 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/55566 , A61K2039/6018 , A61K2039/6037 , A61K2039/627 , A61K2039/70 , C12N2710/20022 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , Y02A50/412
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公开(公告)号：EP1171405A1
公开(公告)日：2002-01-16
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an α-oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an α-oxoaldehyde function and α-oxoaldehyde peptides obtained by said method.
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14.发明公开MULTIMERIC COMPOUNDS OF A KRINGLE DOMAIN FROM THE HEPATOCYTE GROWTH FACTOR / SCATTER FACTOR (HGF/SF) 审中-公开来自肝细胞生长因子/散发因子（HGF / SF）的KRINGLE结构域的多元化合物
公开(公告)号：EP3253782A1
公开(公告)日：2017-12-13
申请号：EP16701313.5
申请日：2016-01-21
申请人： Université des Sciences et Technologies De Lille - Lille 1 , Centre National de la Recherche Scientifique , Institut Pasteur de Lille , Université de Lille 2 Droit et Santé , Universita' Degli Studi Di Pavia
发明人： VICOGNE, Jerome , MELNYK, Oleg , OLLIVIER, Nathalie , ADRIAENSSENS, Eric , LECLERCQ, Berenice , SIMONNEAU, Claire , DE NOLA, Giovanni , GHERARDI, Ermanno , DE JONGE, Hugo
IPC分类号： C07K14/475 , A61K38/00 , G01N33/74
CPC分类号： A61K47/665 , A61K38/00 , A61K38/1833 , A61K47/557 , A61K49/0002 , C07K14/4753 , G01N33/502 , G01N33/5023 , G01N33/582
摘要： Disclosed are multimeric compounds of K1 domains from the Hepatocyte Growth Factor/Scatter Factor (HGF/SF) being able to induce activation of the tyrosine kinase receptor MET and their uses.
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公开(公告)号：EP3247719A1
公开(公告)日：2017-11-29
申请号：EP16701312.7
申请日：2016-01-21
申请人： Université des Sciences et Technologies De Lille - Lille 1 , Centre National de la Recherche Scientifique , Institut Pasteur de Lille , Université de Lille 2 Droit et Santé , Universita' Degli Studi Di Pavia
发明人： VICOGNE, Jerome , MELNYK, Oleg , OLLIVIER, Nathalie , ADRIAENSSENS, Eric , LECLERCQ, Berenice , SIMONNEAU, Claire , DE NOLA, Giovanni , GHERARDI, Ermanno , DE JONGE, Hugo
IPC分类号： C07K14/475 , A61K38/00 , C12N15/63 , G01N33/74
CPC分类号： C07K14/4753 , A61K38/00 , C12N15/63
摘要： Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.
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">16.发明公开DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES. 有权DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
公开(公告)号：EP1390751A2
公开(公告)日：2004-02-25
申请号：EP02740818.6
申请日：2002-05-27
申请人： Societe d'Etude et de Developpement des Antigenes, Combinatoires - Sedac Therapeutics , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , INSTITUT PASTEUR DE LILLE , UNIVERSITE DE LILLE II
发明人： MELNYK, Oleg , GRAS-MASSE, Hélène , OLIVIER, Christophe , DURAND, Jean-Olivier , AURIAULT, Claude , DUBURCQ, Xavier , BOUZIDI, Ahmed , GARCIA, Jean-Michel , EL-MAHDI, Ouafâa
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54353
摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .
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17.发明公开
公开(公告)号：EP1487484A2
公开(公告)日：2004-12-22
申请号：EP03727589.8
申请日：2003-03-14
申请人： INSTITUT PASTEUR DE LILLE , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE LILLE II , INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM) , SEDAC-Therapeutics (SOCIETE D'ETUDE ET DE DEVELOPPEMENT DES ANTIGENES COMBINATOIRES)
发明人： GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle , DUPUIS, Marion , GRAS MASSE, Hélène , BOUREL, Line , MELNYK, Oleg , JOLY, Pascal , BONNET, Dominique , MALINGUE, Frédéric , GRAND JEAN, Cyrille , GEORGES, Bertrand
CPC分类号： C07K14/005 , A61K39/385 , A61K2039/542 , A61K2039/55555 , A61K2039/6018 , A61K2039/627 , C12N2740/15022 , C12N2740/16022 , C12N2770/24222
摘要： The invention relates to the use of a mixture containing at least lipopeptides for vaccine production. Said lipopeptides comprise a peptide compound which has been bound in solution by means of a hydrazone linkage to at least one non-peptidic lipophilic carrier. The invention also relates to native sequences NS3 of the HCV.
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18.发明公开PRODUITS COMPRENANT UN SUPPORT SUR LEQUEL SONT FIXES DES ACIDES NUCLEIQUES ET LEUR UTILISATION COMME PUCE A ADN 审中-公开WITH NUCLEIC包括载波产品及其使用的AS生物芯片
公开(公告)号：EP1235839A2
公开(公告)日：2002-09-04
申请号：EP00988891.8
申请日：2000-12-07
申请人： INSTITUT PASTEUR DE LILLE , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR (FONDATION)
发明人： MELNYK, Oleg , OLIVIER, Christophe , OLLIVIER, Nathalie , HOT, DavidRésidence Le Clos Saint Ruth , HUOT, Ludovic , LEMOINE, Yves , WOLOWCZUK, Isabelle , HUYNH-DINH, Tam , GOUYETTE, Catherine , GRAS-MASSE, Hélène
CPC分类号： C07H21/00 , B01J2219/00497 , B01J2219/00529 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00659 , B01J2219/00693 , B01J2219/00707 , B01J2219/00722 , C07B2200/11 , C12Q2565/501 , C40B40/06
摘要： The invention concerns products comprising a support whereon are fixed nucleic acids and their preparation method and use as DNA support. The invention also concerns functionalised supports, oligonucleotides and DNA's modified in position 5' by a group selected in the group consisting of tartaric acid, serine, threonine, their derivatives and the α-oxoaldehyde group, and the methods for preparing them. The invention further concerns a method for fixing a nucleic acid on a support.
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19.发明公开PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET AU MOINS UN AUTRE COMPOSE ET SES APPLICATIONS 有权FOR之间的肽和至少另一个连接在溶液中，离合器形式及其用途
公开(公告)号：EP1206482A2
公开(公告)日：2002-05-22
申请号：EP00958701.5
申请日：2000-08-18
CPC分类号： C07K7/06 , A61K39/00 , C07K1/006 , C07K1/1075 , C07K1/1077 , C07K7/08 , C07K14/001
摘要： The invention concerns a method for coupling a peptide with at least a compound A, of the non-peptide type, bearing a function selected among the group consisting of carboxylic acid functions and alcohol functions. The invention is characterised in that said coupling comprises a step which consists in producing, in solution, a hydrazide bond between said peptide and said compound A. The invention also concerns modified peptides essentially formed by a peptide bound by a hydrazide bond to at least a compound A as defined above, such as a lipid, a sugar, an alcohol or a fluorescent marker, as well as the uses of said modified peptides. The invention further concerns the use of N,N'-tri(Boc)hydrazinoacetic and N,N'-di(Boc)hydrazinoacetic acids to functionalize a peptide with a α-hydrazinoacetic group.
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20.发明公开LIPOPEPTIDES INDUCTEURS DE CYTOTOXICITE T LYMPHOCYTAIRE PORTANT AU MOINS UN EPITOPE T AUXILIAIRE, ET LEURS UTILISATIONS POUR LA VACCINATION 有权脂肽细胞毒性T淋巴细胞ANSWER引诱，与至少一个表位T辅助细胞，及其作为疫苗
公开(公告)号：EP1068226A1
公开(公告)日：2001-01-17
申请号：EP99911884.7
申请日：1999-04-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： LE GAL, Frédérique, Anne , GUILLET, Jean, Gérard , GAHERY-SEGARD, Hanne , GRAS-MASSE, Hélène , MELNYK, Oleg , TARTAR, André
IPC分类号： C07K14/025 , C07K14/16 , A61K39/295 , A61K47/48
CPC分类号： C07K14/005 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/55566 , A61K2039/6018 , A61K2039/6037 , A61K2039/627 , A61K2039/70 , C12N2710/20022 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , Y02A50/412
摘要： The invention concerns lipopeptides comprising at least one auxiliary T epitope, at least one CTL epitope and at least a lipid residue, characterised in that the epitopes and the lipid part, and the epitopes are independently separated by amino acids, called spacers, comprising amino acid chains charged in neutral medium, ensuring affinity for water of said lipopeptides. The invention also concerns the use of said lipopeptides for inducing an immune response against HIV and BHV, papillo mavirus, melanoma p-53, or malaria.
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