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公开(公告)号：EP1171405B1
公开(公告)日：2007-01-03
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an alpha -oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an alpha -oxoaldehyde function and alpha -oxoaldehyde peptides obtained by said method.
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2.发明授权MICELLES MIXTES DE LIPOPEPTIDES POUR L'INDUCTION D'UNE REPONSE IMMUNITAIRE 有权MISCMICELLEN关闭脂肽诱导免疫应答
公开(公告)号：EP1035866B1
公开(公告)日：2006-05-17
申请号：EP98958314.1
申请日：1998-12-02
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： GRAS-MASSE, Hélène , BOSSUS, Marc , LIPPENS, Guy , WIERUSZESKI, Jean-Michel , TARTAR, André , GUILLET, Jean-Gérard , BOURGAULT-VILLADA, Isabelle
CPC分类号： A61K39/015 , A61K9/1075 , A61K39/12 , A61K39/385 , A61K2039/55577 , A61K2039/6018 , A61K2039/70 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334 , Y02A50/412
摘要： The invention concerns mixed micelles or micro-aggregates for inducing an immune response containing at least: a first lipopeptide comprising a CTL epitope and at least a first lipid motif; and a second lipopeptide comprising at least an auxiliary T epitope and at least a lipid motif, whereof the type can be different from the first lipopeptide motif. Said micelles can be used as medicines and vaccines.
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3.发明授权PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET AU MOINS UN AUTRE COMPOSE ET SES APPLICATIONS 有权FOR之间的肽和至少另一个连接在溶液中，离合器形式及其用途
公开(公告)号：EP1206482B1
公开(公告)日：2003-09-24
申请号：EP00958701.5
申请日：2000-08-18
CPC分类号： C07K7/06 , A61K39/00 , C07K1/006 , C07K1/1075 , C07K1/1077 , C07K7/08 , C07K14/001
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4.发明授权LIPOPEPTIDES INDUCTEURS DE CYTOTOXICITE T LYMPHOCYTAIRE PORTANT AU MOINS UN EPITOPE T AUXILIAIRE, ET LEURS UTILISATIONS POUR LA VACCINATION 有权脂肽细胞毒性T淋巴细胞ANSWER引诱，与至少一个表位T辅助细胞，及其作为疫苗
公开(公告)号：EP1068226B1
公开(公告)日：2005-04-20
申请号：EP99911884.7
申请日：1999-04-06
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR DE LILLE
发明人： LE GAL, Frédérique, Anne , GUILLET, Jean, Gérard , GAHERY-SEGARD, Hanne , GRAS-MASSE, Hélène , MELNYK, Oleg , TARTAR, André
IPC分类号： C07K14/025 , C07K14/16 , A61K39/295 , A61K47/48
CPC分类号： C07K14/005 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K47/646 , A61K2039/55566 , A61K2039/6018 , A61K2039/6037 , A61K2039/627 , A61K2039/70 , C12N2710/20022 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , Y02A50/412
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5.发明公开
公开(公告)号：EP1290018A2
公开(公告)日：2003-03-12
申请号：EP01938317.3
申请日：2001-05-23
申请人： Societé d'Etudes et de Developpment des Antigenes Combinatoires - SEDAC Therapeutics , Centre National de la Recherche Scientifique ( CNRS) , Institut Pasteur De Lille
CPC分类号： C07K14/005 , C07K1/00 , C07K1/047 , C12N2770/24222
摘要： The invention concerns the designing and synthesis of immunogenic peptides corresponding to restricted regions of the proteins of virus involving an immune response to T cells and convergent combinatory peptide libraries derived from said regions. The invention is particular applicable to hepatitis C virus and useful for producing vaccine preparations against same.
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公开(公告)号：EP1171405A1
公开(公告)日：2002-01-16
申请号：EP00920852.1
申请日：2000-04-20
IPC分类号： C07B41/06 , C07B61/00 , C07K1/107 , G01N33/547 , C12Q1/68
CPC分类号： C40B99/00 , C07B41/06 , C07B61/00 , C07D307/24 , C07K1/042 , C40B40/04 , C40B40/10 , C40B50/14 , Y02P20/55
摘要： The invention concerns a functionalised solid support for the synthesis of compounds comprising at least an α-oxoaldehyde function, its method for preparation and its uses, in particular for preparing a bank of organic compounds, a diagnostic reagent, a microtitration plate and a biochip, such as a DNA chip. The invention also concerns a method for the synthesis of organic compounds comprising at least an α-oxoaldehyde function and α-oxoaldehyde peptides obtained by said method.
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7.发明授权PROCEDE DE COUPLAGE, EN SOLUTION, ENTRE UN PEPTIDE ET UN VECTEUR LIPOPHILE ET SES APPLICATIONS 有权PROCESS FOR IN之间的肽和亲脂性化合物溶液的离合器，及其用途
公开(公告)号：EP1315739B1
公开(公告)日：2004-08-18
申请号：EP01967454.8
申请日：2001-09-07
申请人： INSTITUT PASTEUR DE LILLE Etablissement Public , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
IPC分类号： C07K1/107 , A61K47/48 , C07C233/03 , C07D209/32 , A61K39/395
CPC分类号： C07D263/04 , A61K38/00 , A61K47/54 , C07C235/74 , C07K1/1077
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8.发明公开DISPOSITIF DE PRESENTATION DE PEPTIDES OU DE PROTEINES, SON PROCEDE DE PREPARATION ET SES UTILISATIONS. 有权多肽或蛋白质演示装置，处理用于生产和它们的用途
公开(公告)号：EP1507792A1
公开(公告)日：2005-02-23
申请号：EP03755166.0
申请日：2003-05-15
发明人： MELNYK, Oleg , DUBURCQ, Xavier , GRAS-MASSE, Hélène , OLIVIER, Christophe , ZHOU, Fengling , AURIAULT, Claude , BOUZIDI, Ahmed
IPC分类号： C07K1/107 , C07K17/02 , G01N33/543
CPC分类号： C07K17/14 , C07K1/1077 , Y10T436/25
摘要： The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionally complementary molecules of said polypeptides, i.e. antibodies.
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">9.发明授权DISPOSITIF DE PRESENTATION DE POLYPEPTIDES, UTILISABLE COMME "PUCE" POUR LA DETECTION MINIATURISEE DE MOLECULES. 有权DEVICE FORPOLYPEPTIDPRÄSENTATION，用作传感器芯片检测分子的小型化
公开(公告)号：EP1390751B1
公开(公告)日：2011-11-30
申请号：EP02740818.6
申请日：2002-05-27
发明人： MELNYK, Oleg , GRAS-MASSE, Hélène , OLIVIER, Christophe , DURAND, Jean-Olivier , AURIAULT, Claude , DUBURCQ, Xavier , BOUZIDI, Ahmed , GARCIA, Jean-Michel , EL-MAHDI, Ouafâa
IPC分类号： G01N33/543 , G01N33/68
CPC分类号： G01N33/54353
摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .
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10.发明授权DISPOSITIF DE PRESENTATION DE PEPTIDES OU DE PROTEINES, SON PROCEDE DE PREPARATION ET SES UTILISATIONS. 有权多肽或蛋白质演示装置，处理用于生产和它们的用途
公开(公告)号：EP1507792B1
公开(公告)日：2006-09-06
申请号：EP03755166.0
申请日：2003-05-15
发明人： MELNYK, Oleg , DUBURCQ, Xavier , GRAS-MASSE, Hélène , OLIVIER, Christophe , ZHOU, Fengling , AURIAULT, Claude , BOUZIDI, Ahmed
IPC分类号： C07K1/107 , C07K17/02 , G01N33/543
CPC分类号： C07K17/14 , C07K1/1077 , Y10T436/25
摘要： The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionally complementary molecules of said polypeptides, i.e. antibodies.
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