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公开(公告)号：EP4034541A1
公开(公告)日：2022-08-03
申请号：EP20780980.7
申请日：2020-09-22
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公开(公告)号：EP4028401A1
公开(公告)日：2022-07-20
申请号：EP20772007.9
申请日：2020-09-07
发明人： GRETHER, Uwe , HORNSPERGER, Benoit , KROLL, Carsten , KUHN, Bernd , LUTZ, Marius Daniel Rinaldo , O'HARA, Fionn , RICHTER, Hans
IPC分类号： C07D498/04 , A61P25/28 , A61P29/00 , A61P35/00 , C07D487/04 , A61K31/5383
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公开(公告)号：EP3883936A1
公开(公告)日：2021-09-29
申请号：EP19809026.8
申请日：2019-11-20
发明人： KUHN, Bernd , GRETHER, Uwe , HORNSPERGER, Benoit , RICHTER, Hans , KROLL, Carsten , GROEBKE ZBINDEN, Katrin , O`HARA, Fionn , ROMBACH, Didier , LUTZ, Marius Daniel Rinaldo
IPC分类号： C07D498/04 , A61P25/28 , A61K31/5365 , C07D519/00
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公开(公告)号：EP3837263A1
公开(公告)日：2021-06-23
申请号：EP19755855.4
申请日：2019-08-12
发明人： BELL, Charles , BENZ, Joerg , GOBBI, Luca , GRETHER, Uwe , GROEBKE ZBINDEN, Katrin , HORNSPERGER, Benoit , KOCER, Buelent , KROLL, Carsten , KUHN, Bernd , LUTZ, Marius Daniel Rinaldo , O`HARA, Fionn , RICHTER, Hans , RITTER, Martin , ROMBACH, Didier , KURATLI, Martin
IPC分类号： C07D498/04 , A61K31/5365 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/24 , A61P25/28 , A61P35/00
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公开(公告)号：EP3724186A1
公开(公告)日：2020-10-21
申请号：EP18814942.1
申请日：2018-12-13
发明人： BELL, Charles , BENZ, Joerg , GRETHER, Uwe , HORNSPERGER, Benoit , KOCER, Buelent , KUHN, Bernd , RICHTER, Hans , TSUCHIYA, Satoshi
IPC分类号： C07D413/14 , A61K31/538 , C07D413/06 , A61P25/00 , A61P35/00
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公开(公告)号：EP3717477A1
公开(公告)日：2020-10-07
申请号：EP18812115.6
申请日：2018-11-27
发明人： BENZ, Joerg , GRETHER, Uwe , HORNSPERGER, Benoit , KOCER, Buelent , KUHN, Bernd , RICHTER, Hans , TSUCHIYA, Satoshi , BELL, Charles , WU, Xiang , YAN, Xiaofei , GOBBI, Luca
IPC分类号： C07D413/14 , C07D401/06 , C07D413/06 , C07D417/12 , C07D265/36 , A61P25/24 , A61P25/04 , A61P25/16 , A61P25/22 , A61P25/28 , A61P35/00 , A61P25/06 , A61P25/08 , A61K31/536
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17.发明授权2,3-SUBSTITUTED INDAZOLE OR 4,5,6,7-TETRAHYDRO-INDAZOLES AS FXR MODULATORS AGAINST DYSLIPIDEMIA AND RELATED DISEASES 有权2,3-取代的4,5,6,7-吲唑或TETRAHYDROINDAZOLE AS调节剂的FXR AGAINST血脂异常和相关疾病
公开(公告)号：EP2344459B1
公开(公告)日：2013-12-25
申请号：EP09783005.3
申请日：2009-09-15
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , GRETHER, Uwe , KUHN, Bernd , RICHTER, Hans , TAYLOR, Sven
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , A61P3/06 , A61P3/10 , A61K31/416
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12
摘要： This invention relates to novel indazole or 4,5,6,7-tetrahydro-indazole derivatives of formula I wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
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公开(公告)号：EP2222645B1
公开(公告)日：2013-03-20
申请号：EP08849394.5
申请日：2008-11-05
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , GRETHER, Uwe , MARTIN, Rainer E. , PLANCHER, Jean-Marc , RICHTER, Hans , TAYLOR, Sven , YANG, Minmin
IPC分类号： C07D235/06 , C07D405/12 , C07D409/12 , A61K31/4184 , A61P3/00
CPC分类号： C07D235/06 , C07D405/12 , C07D409/12
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公开(公告)号：EP2188263B1
公开(公告)日：2012-06-27
申请号：EP08787302.2
申请日：2008-08-19
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , GRETHER, Uwe , MARTIN, Rainer E. , PLANCHER, Jean-Marc , RICHTER, Hans , TAYLOR, Sven , YANG, Minmin
IPC分类号： C07D235/12 , C07D401/12 , C07D405/12 , A61K31/4184 , A61K31/4402 , A61P1/16 , A61P3/10 , A61P9/00 , A61P19/00 , A61P25/16 , A61P25/28 , A61P35/00
CPC分类号： C07D235/12 , C07D401/12 , C07D405/12
摘要： The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
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公开(公告)号：EP2225221A2
公开(公告)日：2010-09-08
申请号：EP08865563.4
申请日：2008-12-12
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer, E. , PLANCHER, Jean-Marc , RICHTER, Hans , TAYLOR, Sven , YANG, Minmin
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D235/12 , C07D401/12 , C07D401/14
摘要： This invention relates to novel carboxyl- or hydroxylsubstituted benzimidazole derivatives of formula (I) wherein R
1 to R
6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
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