公开(公告)号：EP1317473A1

公开(公告)日：2003-06-11

申请号：EP01916070.4

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07K1/00 ,  C12Q1/68 ,  C07H21/02

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1317471A1

公开(公告)日：2003-06-11

申请号：EP01984534.6

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/47 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1254157A1

公开(公告)日：2002-11-06

申请号：EP01908615.6

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  BARASH, Steven, C. ,  RUBEN, Steven, M. ,  BIRSE, Charles, E.

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C12N9/6424 ,  C07K14/47

摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

公开(公告)号：EP1144614A2

公开(公告)日：2001-10-17

申请号：EP00909904.5

申请日：2000-01-18

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M. ,  EBNER, Reinhard ,  YOUNG, Paul, E. ,  NI, Jian ,  MOORE, Paul, A. ,  KOMATSOULIS, George ,  BIRSE, Charles, E.

IPC分类号： C12N15/00 ,  C07K14/47

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1325021A1

公开(公告)日：2003-07-09

申请号：EP01910338.1

申请日：2001-01-17

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/47 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1322659A1

公开(公告)日：2003-07-02

申请号：EP01985257.3

申请日：2001-01-17

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C12Q1/6883

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及新的人分泌蛋白和含有编码这些蛋白的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白的载体，宿主细胞，抗体和重组方法。 本发明进一步涉及诊断和治疗方法，用于诊断和治疗与这些新的人类分泌蛋白相关的疾病，病症和/或病症。

公开(公告)号：EP1322657A1

公开(公告)日：2003-07-02

申请号：EP01914333.8

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C12Q1/6876 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1259527A1

公开(公告)日：2002-11-27

申请号：EP00978417.4

申请日：2000-11-08

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  KOMATSOULIS, George, A. ,  BIRSE, Charles, E. ,  NI, Jian ,  MOORE, Paul, A.

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1237901A1

公开(公告)日：2002-09-11

申请号：EP00976756.7

申请日：2000-11-01

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  KOMATSOULIS, George, A. ,  MOORE, Paul, A. ,  BIRSE, Charles, E. ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1179060A1

公开(公告)日：2002-02-13

申请号：EP00935903.5

申请日：2000-05-11

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M. ,  MOORE, Paul, A. ,  YOUNG, Paul, E. ,  KOMATSOULIS, George, A. ,  BIRSE, Charles, E. ,  DUAN, Roxanne, D. ,  FLORENCE, Kimberly, A. ,  SOPPET, Daniel, R.

IPC分类号： C12N15/11 ,  C07H21/04 ,  C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.