公开(公告)号：EP1228082A1

公开(公告)日：2002-08-07

申请号：EP00947553.4

申请日：2000-07-20

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  RUBEN, Steven, M. ,  EBNER, Reinhard ,  DUAN, Roxanne, D. ,  NI, Jian ,  SOPPET, Daniel, R. ,  MOORE, Paul, A. ,  SHI, Yang-gu ,  LAFLEUR, David, W. ,  OLSEN, Henrik, S. ,  BIRSE, Charles, E. ,  KOMATSOULIS, Georges, A.

IPC分类号： C07H21/04 ,  C07K5/04 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/622 ,  C07K2319/30

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1224285A2

公开(公告)日：2002-07-24

申请号：EP00976635.3

申请日：2000-10-25

申请人： Human Genome Sciences, Inc.

发明人： RUBEN, Steven, M. ,  KOMATSOULIS, George, A. ,  BIRSE, Charles, E. ,  NI, Jian ,  SOPPET, Daniel, R.

IPC分类号： C12N15/12 ,  A61K39/12

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1317472A1

公开(公告)日：2003-06-11

申请号：EP01984565.0

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, Roxanne, D. ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07H5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/70571 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4713

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1311669A1

公开(公告)日：2003-05-21

申请号：EP01984537.9

申请日：2001-01-17

申请人： Human Genome Sciences, Inc.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian

IPC分类号： C12N15/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1254242A1

公开(公告)日：2002-11-06

申请号：EP01910339.9

申请日：2001-01-17

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig, A. ,  KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H. ,  FISCELLA, Michele ,  NI, Jian ,  RUBEN, Steven, M. ,  BARASH, Steven, C.

IPC分类号： C12N15/60 ,  C12N9/88 ,  A61K31/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/18 ,  C07K2319/30 ,  C12N9/6424 ,  C12N2799/026 ,  C12Q1/6883 ,  G01N2500/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1218408A1

公开(公告)日：2002-07-03

申请号：EP00965302.3

申请日：2000-09-22

申请人： Human Genome Sciences, Inc.

发明人： NI, Jian ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  EBNER, Reinhard ,  FISCELLA, Michele ,  KOMATSOULIS, George, A. ,  LAFLEUR, David, W. ,  MOORE, Paul, A. ,  OLSEN, Henrik, S. ,  ROSEN, Craig, A. ,  RUBEN, Steven, A. ,  SOPPET, Daniel, R. ,  YOUNG, Paul, E. ,  WEI, Ping ,  FLORENCE, Kimberly, A.

IPC分类号： C07K14/47 ,  C12N5/10 ,  C12N5/16 ,  C12N15/12 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1208191A1

公开(公告)日：2002-05-29

申请号：EP00959224.7

申请日：2000-08-11

申请人： HUMAN GENOME SCIENCES, INC.

发明人： BIRSE, Charles, E. ,  ROSEN, Craig, A.

IPC分类号： C12N1/21 ,  C12N15/12 ,  C12N15/63 ,  C07K14/435

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： This invention relates to newly identified colon or colon cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'colon cancer antigens', and the use of such colon antigens for detecting disorders of the gastrointestinal system, particularly the presence of colon cancer and colon cancer metastases. This invention relates to colon cancer antigens as well as vectors, host cells, antibodies directed to colon cancer antigens and the recombinant methods and synthetic methods for producing the same. Also provided are diagnostic methods for detecting, treating, preventing and/or prognosing disorders related to the colon, including colon cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of colon cancer antigens of the invention. The present invention further relates to inhibiting the production and function of the polypeptides of the present invention.

公开(公告)号：EP1206573A1

公开(公告)日：2002-05-22

申请号：EP00939504.7

申请日：2000-06-02

申请人： HUMAN GENOME SCIENCES, INC.

发明人： RUBEN, Steven, M. ,  BIRSE, Charles, E. ,  DUAN, Roxanne, D. ,  SOPPET, Daniel, R. ,  ROSEN, Craig, A. ,  SHI, Yanggu ,  LAFLEUR, David, W. ,  OLSEN, Henrik, S. ,  EBNER, Reinhard ,  FLORENCE, Kimberly, A. ,  NI, Jian ,  YOUNG, Paul, E.

IPC分类号： C12Q1/68 ,  C07H21/02

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1203005A2

公开(公告)日：2002-05-08

申请号：EP00957451.8

申请日：2000-08-16

申请人： HUMAN GENOME SCIENCES, INC.

发明人： ROSEN, Craig, A. ,  NI, Jian ,  FLORENCE, Kimberly, A. ,  FISCELLA, Michele ,  WEI, Ping ,  BAKER, Kevin, P. ,  BIRSE, Charles, E. ,  YOUNG, Paul, E. ,  KOMATSOULIS, George, A. ,  MOORE, Paul, A. ,  SOPPET, Daniel, R.

IPC分类号： C07H21/02 ,  C07H21/04 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12P21/06 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：EP1325020A1

公开(公告)日：2003-07-09

申请号：EP01910321.7

申请日：2001-01-09

申请人： HUMAN GENOME SCIENCES, INC.

发明人： KOMATSOULIS, George, A. ,  BAKER, Kevin, P. ,  ROSEN, Craig, A. ,  BIRSE, Charles, E. ,  SOPPET, Daniel, R. ,  OLSEN, Henrik, S. ,  NI, Jian ,  FISCELLA, Michele ,  MOORE, Paul, A. ,  WEI, Ping ,  EBNER, Reinhard ,  DUAN, D., Roxanne ,  SHI, Yanggu ,  CHOI, Gil, H.

IPC分类号： C07H21/04 ,  C07H21/02 ,  C07K5/00 ,  C07K14/00 ,  C12Q1/68 ,  C12N1/21 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.