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公开(公告)号：EP0939804A1
公开(公告)日：1999-09-08
申请号：EP96939612.0
申请日：1996-10-25
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian
IPC分类号： C12N15 , A61K38 , A61K39 , A61K45 , A61K48 , A61P11 , A61P29 , A61P37 , C07K14 , C07K16 , C12N1 , C12N5 , C12P21 , A61K35
CPC分类号： C07K14/52 , A61K38/00 , A61K2039/505 , Y02A50/412
摘要： The present invention relates to a novel Neutrokine alpha protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine alpha protein including soluble forms of the extracellular domain. Neutrokine alpha polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine alpha activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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公开(公告)号：EP0775199A1
公开(公告)日：1997-05-28
申请号：EP94923172.0
申请日：1994-05-31
IPC分类号： C12N15 , A61K38 , A61K48 , A61P1 , A61P9 , A61P17 , A61P19 , A61P29 , A61P43 , C07H21 , C07K16 , C12N9 , C12P21 , C12R1
CPC分类号： C12N9/0089 , A61K38/00
摘要： Polynucleotides which encode the polypeptide SOD-4, as well as such polypeptides, and antibodies against the polypeptide and the use of the polypeptide as a pharmaceutical for treating cerebral ischaemia, ulcers, inflammation, arrhythmia, oedema and paraquat intoxication as well as rheumatoid arthritis, osteoarthritis and radiation injury.
摘要翻译： 编码多肽SOD-4的多核苷酸以及这样的多肽和针对多肽的抗体以及该多肽作为用于治疗大脑局部缺血，溃疡，炎症，心律失常，水肿和百草枯中毒以及类风湿性关节炎的药物的用途， 骨关节炎和辐射损伤。
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公开(公告)号：EP0939804B1
公开(公告)日：2005-08-17
申请号：EP96939612.6
申请日：1996-10-25
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian
CPC分类号： C07K14/52 , A61K38/00 , A61K2039/505 , Y02A50/412
摘要： The present invention relates to a novel Neutrokine alpha protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine alpha protein including soluble forms of the extracellular domain. Neutrokine alpha polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine alpha activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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公开(公告)号：EP1161451A2
公开(公告)日：2001-12-12
申请号：EP00913602.9
申请日：2000-02-25
发明人： YU, Guo-Liang , NI, Jian , ROSEN, Craig, A.
CPC分类号： C07K14/5255 , A61K38/00
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
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公开(公告)号：EP1040117A1
公开(公告)日：2000-10-04
申请号：EP98966461.0
申请日：1998-12-17
发明人： MOORE, Paul, A. , RUBEN, Steven, M. , CARTER, Kenneth, C. , SHI, Yang-gu , ROSEN, Craig, A. , SOPPET, Daniel, R. , KYAW, Hla , WEI, Ying-Fei , FLORENCE, Kimberly , DUAN, Roxanne, D. , FLORENCE, Charles , GREENE, John, M. , FENG, Ping , FERRIE, Ann, M. , YU, Guo-Liang , JANAT, Fouad , NI, Jian
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4718 , C07K14/705 , C07K2319/00 , C07K2319/02 , C12N15/11 , C12N2799/026
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP1002132A1
公开(公告)日：2000-05-24
申请号：EP98939208.9
申请日：1998-08-04
发明人： RUBEN, Steven, M. , SOPPET, Daniel, R. , EBNER, Reinhard , OLSEN, Henrik, S. , YOUNG, Paul, E. , GREENE, John, M. , FERRIE, Ann, M. , YU, Guo-Liang , NI, Jian , ROSEN, Craig, A. , BREWER, Laurie, A. , JANAT, Fouad
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：EP0937147A1
公开(公告)日：1999-08-25
申请号：EP97920102.0
申请日：1997-04-03
发明人： NI, Jian , YU, Guo-Liang , GENTZ, Reiner, L. , LI, Haodong
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
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公开(公告)号：EP0904278A1
公开(公告)日：1999-03-31
申请号：EP96941944.0
申请日：1996-10-31
IPC分类号： C12N15 , A61K31 , A61K38 , A61K39 , A61K45 , A61K48 , A61P19 , A61P29 , A61P33 , A61P37 , C07K14 , C07K16 , C12N1 , C12N5 , C12P21 , C12R1
CPC分类号： C07K14/70575 , A61K38/00 , C07K2319/00 , C12N2799/026 , Y02A50/412
摘要： The present invention relates to a novel member of the TNF-Ligand superfamily, Apoptosis Inducing Molecule II (AIM II). In particular, isolated nucleic acid molecules are provided encoding the human AIM II protein. AIM II polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, autoimmune disease, graft versus host disease, and to inhibit neoplasia, such as tumor cell growth.
摘要翻译： 本发明涉及TNF-配体超家族的新成员，细胞凋亡诱导分子II（AIM II）。 具体而言，提供了编码人AIM II蛋白的分离的核酸分子。 还提供了AIM II多肽以及载体，宿主细胞和用于生产它们的重组方法。 本发明还涉及用于鉴定AIM II活性的激动剂和拮抗剂的筛选方法。 还提供治疗淋巴结病，自身免疫疾病，移植物抗宿主病和抑制瘤形成如肿瘤细胞生长的治疗方法。
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公开(公告)号：EP0898576A1
公开(公告)日：1999-03-03
申请号：EP96941942.0
申请日：1996-10-17
IPC分类号： C12N15 , A61K38 , A61P29 , A61P31 , A61P35 , A61P37 , A61P43 , C07H21 , C07K14 , C12N1 , C12N5 , C12P21 , C12R1
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型含有死亡结构域的受体（DR3和DR3-V1）蛋白。 具体而言，提供了编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供了DR3和DR3-V1多肽以及载体，宿主细胞和用于生产它们的重组方法。 本发明进一步涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：EP0939804B2
公开(公告)日：2011-06-15
申请号：EP96939612.6
申请日：1996-10-25
发明人： YU, Guo-Liang , EBNER, Reinhard , NI, Jian
CPC分类号： C07K14/52 , A61K38/00 , A61K2039/505 , Y02A50/412
摘要： The present invention relates to a novel Neutrokine alpha protein which is a member of the TNF protein family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine alpha protein including soluble forms of the extracellular domain. Neutrokine alpha polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine alpha activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
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