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公开(公告)号：EP2459224A2
公开(公告)日：2012-06-06
申请号：EP10738119.6
申请日：2010-07-26
IPC分类号： A61K47/48
CPC分类号： A61K47/4823 , A61K38/37 , A61K38/4846 , A61K47/60 , A61K47/61 , C08B37/0006 , C12N9/6437 , C12N9/644 , C12N9/96 , C12Y304/21021 , C12Y304/21022
摘要： The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a blood coagulation protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer. In one embodiment of the invention the conjugation is carried out in the presence of the nucleophilic catalyst aniline. In addition the generated oxime linkage can be stabilized by reduction with NaCNBH
3 to form an alkoxyamine linkage.摘要翻译： 本发明涉及使水溶性聚合物与血液凝固蛋白的氧化碳水化合物部分缀合的材料和方法，包括使氧化碳水化合物部分与活化的水溶性聚合物在允许缀合的条件下接触。 更具体地说，本发明涉及上述材料和方法，其中水溶性聚合物含有活性氨氧基，并且其中在水溶性聚合物上的氧化碳水化合物部分和活性氨氧基之间形成肟键。 在本发明的一个实施方案中，缀合在亲核催化剂苯胺存在下进行。 另外，生成的肟键可以通过用NaCNBH 3还原形成烷氧基胺键来稳定。
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公开(公告)号：EP1835938A2
公开(公告)日：2007-09-26
申请号：EP05855442.9
申请日：2005-12-23
IPC分类号： A61K47/48
CPC分类号： C07K14/755 , A61K47/60 , C07K14/775
摘要： The present invention relates to a proteinaceous construc (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex said proteinaceous construc and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
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13.发明公开METHODS FOR THE INACTIVATION OF MICROORGANISMS IN BIOLOGICAL FLUIDS, FLOW THROUGH REACTORS AND METHODS OF CONTROLLING THE LIGHT SUM DOSE TO EFFECTIVELY INACTIVATE MICROORGANISMS IN BATCH REACTORS 审中-公开微生物的生物体液灭活方法; 流经电抗器和方法，用于控制光总剂量在间歇反应器中微生物的有效灭活
公开(公告)号：EP1784229A2
公开(公告)日：2007-05-16
申请号：EP05770162.5
申请日：2005-08-04
发明人： ANDERLE, Heinz , MATTHIESSEN, Peter , SCHWARZ, Hans-Peter , TURECEK, Peter , KREIL, Thomas , BOGGS, Daniel, R.
CPC分类号： A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
摘要： The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivete microorganisms present in a biological fluid, preferably a non-trannsparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
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14.发明授权DETECTION OF PHYSIOLOGICALLY ACCEPTABLE POLYMER MOLECULES USING NEAR INFRARED SPECTROSCOPY 有权PROOF生理安全聚合物分子使用近红外光谱仪
公开(公告)号：EP2356467B1
公开(公告)日：2013-07-10
申请号：EP09768592.9
申请日：2009-12-11
IPC分类号： G01N33/86 , G01N33/68 , G01N21/00 , G01N33/487
CPC分类号： G01N33/6842 , G01N21/359 , G01N33/86 , G01N2333/745 , G01N2333/755 , G01N2333/76 , Y10T436/203332
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公开(公告)号：EP2598172A1
公开(公告)日：2013-06-05
申请号：EP11741727.9
申请日：2011-07-29
发明人： SIEKMANN, Juergen , HAIDER, Stefan , ROTTENSTEINER, Hanspeter , IVENS, Andreas , TURECEK, Peter , ZOECHLING, Oliver
IPC分类号： A61K47/48
摘要： The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
摘要翻译： 本发明涉及将水溶性聚合物与治疗性蛋白质的氧化碳水化合物部分缀合的材料和方法，包括在允许缀合的条件下使氧化的碳水化合物部分与活化的水溶性聚合物接触。 更具体地说，本发明涉及上述材料和方法，其中水溶性聚合物含有活性氨基氧基，其中在水溶性聚合物上的氧化碳水化合物部分和活性氨基氧基之间形成肟或腙键，其中 共轭在亲核催化剂存在下进行。
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16.发明公开
公开(公告)号：EP2326334A2
公开(公告)日：2011-06-01
申请号：EP09778035.7
申请日：2009-08-21
IPC分类号： A61K31/737 , A61K31/727 , A61P7/04
CPC分类号： A61K31/737 , A61K31/727 , A61K38/36 , A61K38/366 , A61K38/37 , A61K38/4846 , A61K38/4853 , A61K45/06 , G01N33/86 , A61K2300/00
摘要： A method of factor Xl-dependent blood coagulation enhancement in a subject in need of enhanced blood coagulation comprising administering a therapeutically effective amount of a composition comprising a non-anticoagulant sulfated polysaccharide (NASP) to the subject. A method of factor Xl-dependent blood coagulation enhancement in a subject in need of enhanced blood coagulation comprising: (i) selecting a subject that is not deficient for factor Xl; and (ii) administering a therapeutically effective amount of a composition comprising a non-anticoagulant sulfated polysaccharide (NASP) to the subject, wherein the NASP enhances blood coagulation in a factor Xl-dependent manner. A method of identifying a non-anticoagulant sulfated polysaccharide (NASP) which is capable of enhancing blood coagulation in dependence on FXI, the method comprising: a) combining a blood or plasma sample comprising activation competent FXI with a composition comprising a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; b) combining a corresponding blood or plasma sample deficient in activation competent FXI with a composition comprising the sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; and c) comparing the clotting or thrombin generation parameters of the blood or plasma samples as determined in steps (a) and (b) with each other, wherein a decrease in the clotting time of the blood sample or an increase in peak thrombin or decrease in peak time of the plasma sample comprising activation competent FXI compared to the clotting time of the blood sample or peak thrombin or peak time of the plasma sample deficient in activation competent FXI is indicative of a NASP which is capable of enhancing blood coagulation in dependence on FXI.
摘要翻译： 鉴定能够根据FXI增强血液凝固的非抗凝血硫酸多糖（NASP）的方法，所述方法包括：a）将具有活化能力的FXI的血液或血浆样品与硫酸化多糖组合并测量凝血或 血液或血浆样品的凝血酶产生参数; b）将在活化能力的FXI中缺乏的相应血液或血浆样品与硫酸化多糖组合并测量血液或血浆样品的凝血酶或凝血酶产生参数; c）比较测定的血液或血浆样品的凝血酶或凝血酶产生参数 在步骤（a）和（b）中。
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17.发明授权A KIT FOR MEASURING THE THROMBIN GENERATION IN A SAMPLE OF A PATIENT'S BLOOD OR PLASMA 有权KIT FOR测量凝血酶在血液或血浆样品的患者
公开(公告)号：EP1730299B1
公开(公告)日：2011-06-01
申请号：EP05729048.8
申请日：2005-03-30
发明人： VARADI, Katalin , TURECEK, Peter , KEIL, Brigitte , PEYRER-HEIMSTAETT, Sylvia , SCHWARZ, Hans-Peter
CPC分类号： A61K31/66 , C12Q1/56 , G01N33/86 , G01N2333/745
摘要： The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
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公开(公告)号：EP2318050A2
公开(公告)日：2011-05-11
申请号：EP09790935.2
申请日：2009-07-29
发明人： TURECEK, Peter , SIEKMANN, Juergen
IPC分类号： A61K47/48 , C07K14/755
CPC分类号： A61K38/37 , A61K38/00 , A61K47/60 , A61K47/61 , C07K14/745
摘要： A composition comprising a conjugate comprising a native Factor VIII modified with a water soluble polymer bound thereto, said water soluble polymer attached to the modified Factor VIII via an oxidised carbohydrate moiety.
摘要翻译： 一种包含缀合物的组合物，其包含与结合到其上的水溶性聚合物修饰的天然因子VIII，所述水溶性聚合物通过氧化的碳水化合物部分连接到修饰的因子VIII上。
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公开(公告)号：EP2010222A1
公开(公告)日：2009-01-07
申请号：EP07754130.8
申请日：2007-03-29
IPC分类号： A61K47/48 , C07K14/755
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
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20.发明公开TREATMENT OF COAGULATION DISEASE BY ADMINISTRATION OF RECOMBINANT VWF 有权治疗KOAGULATIONSERKRANKUNG在给药重组VWF的
公开(公告)号：EP2717905A1
公开(公告)日：2014-04-16
申请号：EP12728919.7
申请日：2012-06-11
发明人： SCHEIFLINGER, Friedrich , TURECEK, Peter , EWENSTEIN, Bruce , WONG, Wing, Yen , SUITER, Tobias, M.
CPC分类号： A61K38/36 , A61K38/37 , A61K2300/00
摘要： The present invention provides methods of treating coagulation disease, including hemophilia and von Willebrand disease by administering recombinant von Willebrand Factor alone or in combination with Factor VIII.
摘要翻译： 本发明提供一种治疗凝血病，包括血友病和血管性血友病通过单独或与因子VIII组合管理重组von Willebrand因子的方法。
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