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11.
公开(公告)号:EP0939822A2
公开(公告)日:1999-09-08
申请号:EP97939629.0
申请日:1997-08-27
申请人: PRESIDENT AND FELLOWS OF HARVARD COLLEGE , The Board of Trustees of The Leland S. Stanford Junior University
IPC分类号: C12N15 , A01K67 , A61K31 , A61K38 , A61K48 , A61P7 , A61P37 , C07K7 , C07K14 , C12N5 , C12N9
CPC分类号: A01K67/0271 , A61K38/00 , C07K7/645 , C07K14/715 , C12N9/16 , C12N9/90
摘要: This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.
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公开(公告)号:EP2367599A1
公开(公告)日:2011-09-28
申请号:EP09830725.9
申请日:2009-12-02
申请人: Massachusetts Institute of Technology , The General Hospital Corporation , President and Fellows of Harvard College
发明人: TSAI, Li-Huei , FISCHER, Andre , HAGGARTY, Stephen , TANG, Weiping , SCHREIBER, Stuart, L. , HOLSON, Edward , WAGNER, Florence , MOYER, Mikel, P.
IPC分类号: A61P25/00 , A61K31/165 , C07C235/42
CPC分类号: A61K31/00 , A61K9/0085 , A61K31/167 , A61K31/353 , A61K31/381 , A61K31/4418 , A61K31/4436 , A61K31/496 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要: The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDACl/2 or HDACl/2/3.
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公开(公告)号:EP1053241A1
公开(公告)日:2000-11-22
申请号:EP99906981.8
申请日:1999-02-12
IPC分类号: C07D498/18 , C07K1/107 , C07K1/14 , C12N15/56
CPC分类号: C07D498/18 , C07K1/1075 , C07K1/1077
摘要: Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.
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