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1.发明公开
公开(公告)号：EP0939822A2
公开(公告)日：1999-09-08
申请号：EP97939629.0
申请日：1997-08-27
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , The Board of Trustees of The Leland S. Stanford Junior University
IPC分类号： C12N15 , A01K67 , A61K31 , A61K38 , A61K48 , A61P7 , A61P37 , C07K7 , C07K14 , C12N5 , C12N9
CPC分类号： A01K67/0271 , A61K38/00 , C07K7/645 , C07K14/715 , C12N9/16 , C12N9/90
摘要： This invention is directed to a modified cyclosporin A and to a modified, genetically engineered version of its receptor, cyclophilin. This invention is further directed to a method for treating host versus graft disease following blood marrow transplantation by transfecting stem cells so that after introduction into a patient the stem cells will express the modified cyclophilin, and, as necessary, administer the modified cyclosporin A to the patient.
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公开(公告)号：EP0820283A1
公开(公告)日：1998-01-28
申请号：EP96912710.0
申请日：1996-04-12
IPC分类号： A61K31 , A61P25 , A61P29 , A61P35 , A61P37 , A61P43 , C07D207 , C07D487 , C07D491 , C07D495 , C07D498 , C12N9
CPC分类号： C07D487/04 , A61K31/4015 , A61K31/407 , C07D491/10 , C07D495/10 , C12N9/6421
摘要： Compounds related to lactacystin and lactacystin β-lactone, pharmaceutical compositions containing the compounds, and methods of use.
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公开(公告)号：EP2321264B1
公开(公告)日：2016-05-04
申请号：EP09800666.1
申请日：2009-07-22
IPC分类号： C07C259/06 , C07C251/86
CPC分类号： C07C259/06 , C07C251/86
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公开(公告)号：EP1994209A2
公开(公告)日：2008-11-26
申请号：EP07835647.4
申请日：2007-01-03
发明人： BARNES, David, W. , KOEHLER, Angela, N. , BRADNER, James, E. , MAZITSCHEK, Ralph , SCHREIBER, Stuart, L.
IPC分类号： C40B30/04
CPC分类号： G01N33/6803 , B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , B01J2219/0074 , C40B30/04 , C40B40/04 , C40B80/00 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/54353 , G01N33/547 , G01N33/552 , G01N33/553
摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm2. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired chemical compound to form a covalent attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; (3) delivering said one or more types of compounds to the solid support; and (4) catalyzing the attachment of the compound to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.
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公开(公告)号：EP3354265A1
公开(公告)日：2018-08-01
申请号：EP18157889.9
申请日：2006-03-22
发明人： ANDERSON, Kenneth, C , BRADNER, James, Elliott , GREENBERG, Edward, Franklin , HIDESHIMA, Teru , KWIATKOWSKI, Nicholas, Paul , MAZITSCHEK, Ralph , SCHREIBER, Stuart, L. , SHAW, Jared , HAGGARTY, Stephen, J
IPC分类号： A61K31/357 , A61K31/42 , A61K31/335 , A61K31/4965 , A61K45/06 , A61K31/35 , A61K31/39 , A61K31/69 , A61K38/55 , A61K49/00 , G01N33/50 , A61K31/422 , A61K38/50 , A61K38/05
CPC分类号： A61K38/05 , A61K31/35 , A61K31/357 , A61K31/422 , A61K31/4965 , A61K31/69 , A61K38/50 , A61K45/06 , A61K49/0008 , G01N33/5011 , A61K2300/00
摘要： The invention relates to methods of treating protein degradation disorders, such as cellular proliferative disorders (e.g., cancer). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating solid tumors. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
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公开(公告)号：EP1127140A2
公开(公告)日：2001-08-29
申请号：EP99958742.1
申请日：1999-11-05
IPC分类号： C12N15/62 , C12N15/52 , C12N9/16 , C12N15/86 , A01K67/027 , G01N33/566
CPC分类号： C07D498/18 , A01K67/0271 , A61K48/00 , C07K14/005 , C07K2319/00 , C07K2319/09 , C07K2319/43 , C07K2319/71 , C07K2319/715 , C12N9/16 , C12N9/90 , C12N15/62 , C12N2710/16622
摘要： This invention provides methods and materials for making and using genetically engineered cells which are responsive to the presence of an FKBP/CAB ligand or a cyclophilin/CAB ligand. The invention relies upon the introduction into cells of recombinant DNAs encoding fusion proteins which are capable of forming a complex with each other in the presence of ligand. One of the fusion proteins contains a calcineurin A/calcineurin B domain (CAB) and at least one heterologous protein domain. The second fusion protein contains a domain derived from an FKBP protein which is capable of binding to an FKBP/CAB ligand and forming a complex with a CAB-containing protein. The second fusion protein may alternatively contain a cyclophilin domain which is capable of binding cyclosporin or other cyclophilin/CAB ligand and forming a complex with a CAB-containing protein. The second fusion protein also contains at least one heterologous domain.
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公开(公告)号：EP1991247B1
公开(公告)日：2015-10-14
申请号：EP07872648.6
申请日：2007-02-14
IPC分类号： C07C259/06 , C07D413/12 , C07D249/04 , C07D249/06
CPC分类号： A61K31/19 , A61K31/44 , A61K47/55 , C07C259/06 , C07D249/04 , C07D249/06 , C07D413/12
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公开(公告)号：EP1861126A2
公开(公告)日：2007-12-05
申请号：EP06748614.2
申请日：2006-03-22
发明人： ANDERSON, Kenneth, C. , BRADNER, James, Elliott , GREENBERG, Edward, Franklin , HIDESHIMA, Teru , KWIATKOWSKI, Nicholas, Paul , MAZITSCHEK, Ralph , SCHREIBER, Stuart, L. , SHAW, Jared
IPC分类号： A61K51/00 , A61K39/395 , A61K33/36
CPC分类号： A61K38/05 , A61K31/35 , A61K31/357 , A61K31/422 , A61K31/4965 , A61K31/69 , A61K38/50 , A61K45/06 , A61K49/0008 , G01N33/5011 , A61K2300/00
摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
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公开(公告)号：EP0820283B1
公开(公告)日：2007-02-14
申请号：EP96912710.9
申请日：1996-04-12
IPC分类号： A61K31/395 , A61K38/00
CPC分类号： C07D487/04 , A61K31/4015 , A61K31/407 , C07D491/10 , C07D495/10 , C12N9/6421
摘要： Compounds related to lactacystin and lactacystin β-lactone, pharmaceutical compositions containing the compounds, and methods of use.
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公开(公告)号：EP2367599A1
公开(公告)日：2011-09-28
申请号：EP09830725.9
申请日：2009-12-02
申请人： Massachusetts Institute of Technology , The General Hospital Corporation , President and Fellows of Harvard College
发明人： TSAI, Li-Huei , FISCHER, Andre , HAGGARTY, Stephen , TANG, Weiping , SCHREIBER, Stuart, L. , HOLSON, Edward , WAGNER, Florence , MOYER, Mikel, P.
IPC分类号： A61P25/00 , A61K31/165 , C07C235/42
CPC分类号： A61K31/00 , A61K9/0085 , A61K31/167 , A61K31/353 , A61K31/381 , A61K31/4418 , A61K31/4436 , A61K31/496 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , A61K2300/00
摘要： The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished by inhibiting HDAC2 and or selectively inhibiting HDACl/2 or HDACl/2/3.
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