公开(公告)号：EP0273388A3

公开(公告)日：1989-04-26

申请号：EP87119132.6

申请日：1987-12-23

申请人： MECT CORPORATION

发明人： Yoshimura, Shoji ,  Shibayama, Shohei ,  Numata, Masaaki ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/04 ,  C07H15/26 ,  A61K31/70 ,  B01J20/26

CPC分类号： C07H15/04 ,  A61K47/26

摘要： A sialic acid derivative having an active carbonyl group represented by the formula [I]:
(wherein R' represents hydrogen or acetyl group; R 2 represents hydrogen, a metal or a lower alkyl group; R 3 represents hydrogen, hydroxyl group, or a residue removed hydrogen from an alcohol portion of an active ester; Ac represents acetyl group; and n is 1 to 20, respectively). This sialic acid derivative [I] can be utilized as a starting material for various complex having a sialic acid in the molecule since it has an active carbonyl group in the molecule so that it shows high reactivity.

公开(公告)号：EP0260606A2

公开(公告)日：1988-03-23

申请号：EP87113263.5

申请日：1987-09-10

申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Nagai, Yoshitaka ,  Awaya, Akira ,  Horikomi, Kazutoshi ,  Kobayashi, Hisashi ,  Mizuchi, Akira ,  Shitori, Yoshiyasu ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H15/04

摘要： A medicament composition for curing neurotic disturbance or disorder comprising a compound represented by the following formula (I) of:

摘要翻译： D：固化神经质扰动或紊乱，其包括由下式（I）表示的化合物的药物组合物

公开(公告)号：EP0255717A2

公开(公告)日：1988-02-10

申请号：EP87111254.6

申请日：1987-08-04

申请人： MECT CORPORATION

发明人： Ogawa, Tomoya ,  Sugimoto, Mamoru ,  Numata, Masaaki ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Nunomura, Shigeki

IPC分类号： C07H15/10 ,  C07H13/04 ,  A61K31/70

CPC分类号： C07H15/10 ,  C07H3/06

摘要： The present invention relates to ganglioside related compounds having. for example. the following formula:
where R 1 represents H or COCH 3 (hereinafter abbreviated to "Ac"); R 2 represents H or CH 3 ; and R 3 represents -OH,

or

These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.

摘要翻译： 本发明涉及具有例如下式的神经节苷脂相关化合物：其中R 1表示H或COCH 3（以下简称为“Ac”）的CHEM> R2表示H或CH3; R3表示-OH，这些神经节苷脂相关化合物可用作膜受体，肿瘤标志物，细胞生长控制物质等，可用于癌症免疫治疗等。

公开(公告)号：EP0194563A2

公开(公告)日：1986-09-17

申请号：EP86102857.9

申请日：1986-03-05

申请人： MECT Corporation

发明人： Shibayama, Shohei ,  Matsuzaki, Yuzi ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/26 ,  A61K31/70

CPC分类号： C07H15/26

摘要： This invention provides a novel compound having a formula such as
This invention also provides a process for preparing such a compound. The novel compound has excellent immunological activity.

公开(公告)号：EP0160925A2

公开(公告)日：1985-11-13

申请号：EP85105295.1

申请日：1985-04-30

申请人： MECT Corporation

发明人： Shibayama, Shohei ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07H15/00 ,  A61K31/70

CPC分类号： C07H15/04

摘要： This invention provides a novel compound having a formula such as
or
This invention also provides a process for preparing such a compound. The novel compound has an excellent immunological activity.

公开(公告)号：EP0316818B1

公开(公告)日：1993-05-26

申请号：EP88118876.7

申请日：1988-11-11

申请人： MECT CORPORATION

发明人： Kawamura, Atsushi ,  Suda, Isao ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： C12P21/08

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K16/30

公开(公告)号：EP0293006B1

公开(公告)日：1991-06-12

申请号：EP88108537.7

申请日：1988-05-27

申请人： MECT CORPORATION

发明人： Fujita, Shuji ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu ,  Ogawa, Tomoya

IPC分类号： C07C233/18 ,  C07C231/00

CPC分类号： C07C233/16

公开(公告)号：EP0316882A3

公开(公告)日：1990-03-14

申请号：EP88119045.8

申请日：1988-11-15

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： C12N5/12 ,  C12P21/08

CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

摘要： A hybridoma capable of procuding a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

公开(公告)号：EP0260606A3

公开(公告)日：1989-12-13

申请号：EP87113263.5

申请日：1987-09-10

申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Nagai, Yoshitaka ,  Awaya, Akira ,  Horikomi, Kazutoshi ,  Kobayashi, Hisashi ,  Mizuchi, Akira ,  Shitori, Yoshiyasu ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H15/04

摘要： A medicament composition for curing neurotic disturbance or disorder comprising a compound represented by the following formula (I) of:

公开(公告)号：EP0177783A3

公开(公告)日：1989-02-22

申请号：EP85111414.0

申请日：1985-09-10

申请人： MECT Corporation

发明人： Ogasawara, Sadanori ,  Hanafusa, Takashi ,  Kariya, Katsuhide ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  C07H13/04

摘要： An expectorant capable of acting on the rheological properties of sputum and capable of directly promoting the ciliary motion. The expectorant contains N-acetyineuramin- ic acid or a pharmaceutically active salt thereof.