专利检索 ap:("SANOFI" OR "VIB VZW" OR "Life Sciences Research Partners VZW" OR "Vrije Universiteit Brussel") AND inv:"HERBERT, Corentin" 第 2 页

11.

发明公开
OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE 审中-公开
标题翻译：的FGF受体ACTIVATING N-酰化八糖，它们的合成及治疗应用

公开(公告)号：EP2464667A2

公开(公告)日：2012-06-20

申请号：EP10761049.5

申请日：2010-08-12

申请人： SANOFI

发明人： DRIGUEZ, Pierre Alexandre , DUCHAUSSOY, Philippe , FONS, Pierre , HERBERT, Corentin , LASSALLE, Gilbert

IPC分类号： C08B37/00 , A61K31/737 , A61P7/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P27/02 , A61P37/00

CPC分类号： C08B37/0063 , A61K31/737 , C07H11/00 , C07H15/04 , C07H15/203 , C08B37/0075

摘要： The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R
1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R
2 is an OSO
3 - or hydroxyl group, R
3 is an alkyl, cycloalkyl, or alky-cycloalkyl group, R
4 is a disaccharide having Formula (II), R
6 is a disaccharide having Formula (III), and R
8 is a disaccharide having Formula (IV), where R
5 , R
7 , and R
9 have OSO
3 or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.