-
1.发明公开
公开(公告)号：EP2590976A1
公开(公告)日：2013-05-15
申请号：EP11743633.7
申请日：2011-07-04
申请人： SANOFI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/517 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D211/82 , C07D211/90 , C07D233/64 , C07D233/88 , C07D233/90 , C07D471/04
摘要： The invention relates to compounds corresponding to formula (I): R4 NN R1 O R2 R3 (I) 5 6 7 8 in which - R2 and R3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C) below: N N O O Ra Ra' N N O Rb Rb' N O Rc Rc'' Rc' (A) (B) (C) in which the wavy lines represent the phenyl nucleus to which R2 and R3 are attached. Preparation process and therapeutic use.
-
2.发明授权EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR 有权酪氨酸激酶受体的胞外变构抑制剂结合域
公开(公告)号：EP2448964B1
公开(公告)日：2017-04-12
申请号：EP10734333.7
申请日：2010-07-02
发明人： CARMELIET, Peter , DE SMET, Frederik , SCHYMKOWITZ, Joost , ROUSSEAU, Frédéric , HERBERT, Corentin
IPC分类号： C07K14/71 , A61K31/4745
CPC分类号： A61K31/437 , C07K14/71 , G01N2500/02
-
3.发明授权
公开(公告)号：EP2590976B1
公开(公告)日：2015-09-16
申请号：EP11743633.7
申请日：2011-07-04
申请人： SANOFI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/517 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D211/82 , C07D211/90 , C07D233/64 , C07D233/88 , C07D233/90 , C07D471/04
-
公开(公告)号：EP2315781A2
公开(公告)日：2011-05-04
申请号：EP09784478.1
申请日：2009-07-07
申请人： Sanofi-Aventis
发明人： BAURIN, Nicolas , BERNE, Pierre-François , BLANCHE, Francis , BONO, Françoise , CAMERON, Béatrice , DABDOUBI, Tarik , HERBERT, Corentin , MIKOL, Vincent , REMY, Elisabeth
IPC分类号： C07K16/28 , C12N15/13 , C12N5/18 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/303 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to FGF-R4 receptor-specific antagonist molecules enabling the inhibition of the activity of said receptor. Said antagonists are, particularly, FGF-R4-specific antibodies enabling the inhibition of the activity of said receptor. The present invention also relates to the therapeutic use of said antibodies, particularly in the field of angiogenesis and in the treatment of certain types of cancer.
-
5.发明授权
公开(公告)号：EP2590975B1
公开(公告)日：2015-08-19
申请号：EP11743363.1
申请日：2011-07-04
申请人： SANOFI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/4709 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D207/32 , C07D207/36 , C07D211/82
-
公开(公告)号：EP2800566A1
公开(公告)日：2014-11-12
申请号：EP13702101.0
申请日：2013-01-03
申请人： SANOFI
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437
摘要： The invention relates to the use of compounds corresponding to formula (I) in which R
2 and R
3 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of the formulae (A), (B) and (C) in which the wavy lines represent the phenyl nucleus to which R
2 and R
3 are attached, or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the treatment of bladder cancer.-
7.发明公开
公开(公告)号：EP2590975A1
公开(公告)日：2013-05-15
申请号：EP11743363.1
申请日：2011-07-04
申请人： SANOFI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K9/2018 , A61K9/2054 , A61K9/2059 , A61K31/4709 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D207/32 , C07D207/36 , C07D211/82
摘要： The invention relates to compounds corresponding to formula (I): N R1 O R3 R4 R2 (I) in which - R3 and R4 together form, with the carbon atoms of the phenyl nucleus to which they are attached, a 6-membered nitrogenous heterocycle corresponding to one of formula (A), (B) or (C) below: N N O O Ra Ra' N N O Rb Rb' N O Rc Rc'' Rc' (A) (B) (C) in which the wavy lines represent the phenyl nucleus to which R3 and R4 are attached. Preparation process and therapeutic use.
-
公开(公告)号：EP2800566B1
公开(公告)日：2015-10-28
申请号：EP13702101.0
申请日：2013-01-03
申请人： SANOFI
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437
-
公开(公告)号：EP2315781B1
公开(公告)日：2015-05-06
申请号：EP09784478.1
申请日：2009-07-07
申请人： SANOFI
发明人： BAURIN, Nicolas , BERNE, Pierre-François , BLANCHE, Francis , BONO, Françoise , CAMERON, Béatrice , DABDOUBI, Tarik , HERBERT, Corentin , MIKOL, Vincent , REMY, Elisabeth
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/303 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30
-
10.发明公开OCTASACCHARIDES N-ACYLES ACTIVATEURS DES RECEPTEURS DES FGFs, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE 审中-公开的FGF受体ACTIVATING N-酰化八糖，它们的合成及治疗应用
公开(公告)号：EP2464667A2
公开(公告)日：2012-06-20
申请号：EP10761049.5
申请日：2010-08-12
申请人： SANOFI
发明人： DRIGUEZ, Pierre Alexandre , DUCHAUSSOY, Philippe , FONS, Pierre , HERBERT, Corentin , LASSALLE, Gilbert
IPC分类号： C08B37/00 , A61K31/737 , A61P7/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P27/02 , A61P37/00
CPC分类号： C08B37/0063 , A61K31/737 , C07H11/00 , C07H15/04 , C07H15/203 , C08B37/0075
摘要： The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R
1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R
2 is an OSO
3 - or hydroxyl group, R
3 is an alkyl, cycloalkyl, or alky-cycloalkyl group, R
4 is a disaccharide having Formula (II), R
6 is a disaccharide having Formula (III), and R
8 is a disaccharide having Formula (IV), where R
5 , R
7 , and R
9 have OSO
3 or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.016 秒)
