公开(公告)号：EP3991730A1

公开(公告)日：2022-05-04

申请号：EP20831251.2

申请日：2020-06-28

申请人： Shanghai Shengdi Pharmaceutical Co., Ltd ,  Shanghai Senhui Medicine Co., Ltd. ,  Jiangsu Hengrui Medicine Co., Ltd.

发明人： HUANG, Jian ,  ZHU, Lingjian ,  ZOU, Yang ,  TANG, Yinggang

IPC分类号： A61K31/438 ,  C07D471/10 ,  A61P1/08 ,  A61P11/06 ,  A61P11/14 ,  A61P25/06 ,  A61P25/22 ,  A61P25/24

摘要： A compound represented by formula II or a pharmaceutically acceptable salt thereof, and a preparation method therefor. The compound represented by formula II is an antagonist of a neurokinin-1 receptor, can be used for treating diseases related to the neurokinin-1 receptor, and can avoid hemolytic effects of drugs and reduce the side effects of drug administration.

公开(公告)号：EP4063381A1

公开(公告)日：2022-09-28

申请号：EP20897067.3

申请日：2020-12-04

申请人： Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Medicine Co., Ltd.

发明人： HUANG, Jian ,  ZHU, Lingjian ,  JIANG, Wei ,  CAO, Weicou

IPC分类号： C07K7/56 ,  A61K38/12 ,  A61P31/10

摘要： The present invention relates to an echinocandin analogue and a preparation method therefor. The compound can be used for preventing or treating fungal infection, or for preventing, stabilizing or inhibiting fungal growth or killing fungi. An exemplary compound is represented by formula I, wherein the definitions of R 1 , R 2 , R 3 and G groups are as described in the description.

公开(公告)号：EP4389745A1

公开(公告)日：2024-06-26

申请号：EP22815335.9

申请日：2022-06-02

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Senhui Medicine Co., Ltd. ,  Retrolead (Shanghai) Biopharma Co., Ltd.

发明人： ZHU, Lingjian ,  HONG, Min ,  TAO, Weifeng ,  WU, Daize ,  PAN, Xiaoyu ,  GAO, Lu ,  HUANG, Jian

IPC分类号： C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00 ,  C07D239/00 ,  C07D241/36 ,  A61K31/50 ,  A61K31/495 ,  A61P31/18

CPC分类号： A61K31/495 ,  A61K31/50 ,  A61P31/18 ,  C07D239/00 ,  C07D241/36 ,  C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00

摘要： The present disclosure provides a pyridone compound having integrase inhibitory activity and a pharmaceutical use thereof. Specifically, the present disclosure provides a compound having a structure shown as formula I or a pharmaceutically acceptable salt thereof, which can be used to treat human immunodeficiency (HIV) infection.

公开(公告)号：EP3778591A1

公开(公告)日：2021-02-17

申请号：EP19784758.5

申请日：2019-04-12

申请人： Jiangsu Hengrui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd

发明人： ZHU, Lingjian ,  GUAN, Zhongjun ,  JIANG, Wei ,  HUANG, Jian

IPC分类号： C07D403/04 ,  C07D207/33 ,  C07C15/42

摘要： The present invention relates to a method for preparing a pyrroloaminopyridazinone compound and intermediates thereof. Specifically relating to a method for preparing the compound of formula (I), the target product being prepared by means of changing the starting materials and intermediates; the present method has the advantages of reactants such as the starting materials being easy to purchase, the reaction conditions being simple and controllable, the post-reaction treatment method being simple, the yield being high, and being beneficial for industrial production.

公开(公告)号：EP3805204A1

公开(公告)日：2021-04-14

申请号：EP19807109.4

申请日：2019-05-23

申请人： Suzhou Suncadia Biopharmaceuticals Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Medicine Co., Ltd.

发明人： LU, Gang ,  HUANG, Jian ,  HU, Yimin ,  ZHU, Lingjian ,  ZOU, Yang ,  CUI, Hua ,  YOU, Qidong ,  ZHANG, Xiaojin

IPC分类号： C07D213/81 ,  A61K31/44 ,  A61P9/10 ,  A61P7/06

摘要： Provided is a method for preparing an alkynyl pyridine prolyl hydroxylase inhibitor. In particular, the method involved uses 3-substituted-5-bromopyridine-2-carboxylic acid protected by different protection groups as raw materials, and by means of condensation, Sonogashira coupling and deprotection, the target compound is obtained. The process reaction conditions are simple, and have no harsh reaction conditions, strong operability, and stable amplification.

公开(公告)号：EP4410307A1

公开(公告)日：2024-08-07

申请号：EP22875194.7

申请日：2022-09-30

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Hengrui Pharmaceutical Co., Ltd. ,  Suncadia Pharmaceuticals Co., Ltd

发明人： XU, Jianyan ,  CAI, Xiaofeng ,  QU, Bolei ,  ZHANG, Ying ,  CHEN, Xiaoxi ,  HE, Feng ,  TAO, Weikang ,  ZHU, Lingjian ,  HONG, Min ,  HUANG, Jian ,  LI, Yanbing ,  XU, Xiaolang ,  HU, Zhipeng ,  XUE, Zhouyang ,  YOU, Lingfeng

IPC分类号： A61K39/395 ,  C07K16/46 ,  C12N5/10 ,  A61K47/68 ,  C12N15/13 ,  A61P35/00

CPC分类号： A61K47/68 ,  A61P35/00 ,  A61K47/68035 ,  A61K47/6851 ,  A61K47/6855 ,  C07K16/28 ,  C07K16/32

摘要： The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereof in the preparation of a medicament for the treatment of cancer. The definitions of groups in the general formula (DL) are as defined in the description.