公开(公告)号：EP4410307A1

公开(公告)日：2024-08-07

申请号：EP22875194.7

申请日：2022-09-30

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Hengrui Pharmaceutical Co., Ltd. ,  Suncadia Pharmaceuticals Co., Ltd

发明人： XU, Jianyan ,  CAI, Xiaofeng ,  QU, Bolei ,  ZHANG, Ying ,  CHEN, Xiaoxi ,  HE, Feng ,  TAO, Weikang ,  ZHU, Lingjian ,  HONG, Min ,  HUANG, Jian ,  LI, Yanbing ,  XU, Xiaolang ,  HU, Zhipeng ,  XUE, Zhouyang ,  YOU, Lingfeng

IPC分类号： A61K39/395 ,  C07K16/46 ,  C12N5/10 ,  A61K47/68 ,  C12N15/13 ,  A61P35/00

CPC分类号： A61K47/68 ,  A61P35/00 ,  A61K47/68035 ,  A61K47/6851 ,  A61K47/6855 ,  C07K16/28 ,  C07K16/32

摘要： The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereof in the preparation of a medicament for the treatment of cancer. The definitions of groups in the general formula (DL) are as defined in the description.

公开(公告)号：EP4389745A1

公开(公告)日：2024-06-26

申请号：EP22815335.9

申请日：2022-06-02

申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. ,  Shanghai Senhui Medicine Co., Ltd. ,  Retrolead (Shanghai) Biopharma Co., Ltd.

发明人： ZHU, Lingjian ,  HONG, Min ,  TAO, Weifeng ,  WU, Daize ,  PAN, Xiaoyu ,  GAO, Lu ,  HUANG, Jian

IPC分类号： C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00 ,  C07D239/00 ,  C07D241/36 ,  A61K31/50 ,  A61K31/495 ,  A61P31/18

CPC分类号： A61K31/495 ,  A61K31/50 ,  A61P31/18 ,  C07D239/00 ,  C07D241/36 ,  C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00

摘要： The present disclosure provides a pyridone compound having integrase inhibitory activity and a pharmaceutical use thereof. Specifically, the present disclosure provides a compound having a structure shown as formula I or a pharmaceutically acceptable salt thereof, which can be used to treat human immunodeficiency (HIV) infection.

公开(公告)号：EP4289857A1

公开(公告)日：2023-12-13

申请号：EP22749058.8

申请日：2022-01-28

申请人： Shanghai Senhui Medicine Co., Ltd. ,  Shanghai Shengdi Pharmaceutical Co., Ltd ,  Jiangsu Hengrui Pharmaceuticals Co., Ltd.

发明人： ZHU, Lingjian ,  HONG, Min ,  TANG, Manping ,  SU, Lu ,  DENG, Mengdie ,  ZHANG, Jingyang ,  REN, Wenming ,  LIN, Kan ,  HUANG, Jian ,  LIAO, Cheng ,  ZHANG, Lianshan

IPC分类号： C07J71/00 ,  C07K16/24 ,  A61K47/68 ,  A61K31/58 ,  A61P37/00

摘要： A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.