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    Immunosuppressant peptides
    14.
    发明公开
    Immunosuppressant peptides 失效
    免疫抑制肽

    公开(公告)号：EP0297456A3

    公开(公告)日：1990-09-26

    申请号：EP88110111.7

    申请日：1988-06-24

    申请人： MERRELL DOW PHARMACEUTICALS INC.

    发明人： Cardin, Alan D. ,  Bowlin, Terry L. ,  Krstenansky, John L.

    IPC分类号： C07K7/08 ,  C07K7/06 ,  A61K37/02 ,  C07K1/04

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2740/10022

    摘要： Novel peptides having a fragment containing 2 or 3 Arg or Lys residues and having a fragment containing 2 or 3 Gly, Leu, Ile, or Thr residues adjacent to the carboxy end of the first fragment and having amino and carboxy tails consisting of chains made up of any amino acids are immunosuppressant agents and can suppress the lymphocyte system by suppressing lymphocyte proliferation.
    The formula is as follows:
          Tn-A-B-C-D-Tc
    wherein
          Tn is an amino terminal residue selected from hydrogen, one or two alkyl groups of from 1 to 6 carbon atoms, one or two acyl groups of from 2 to 10 carbon atoms, carbobenzyloxy, and t -butyloxy­carbonyl;
          A is a peptide fragment containing from 3 to 12 residues of any amino acid;
          B is a peptide fragment containing 2 or 3 amino acid residues selected from Arg and Lys;
          C is a peptide fragment containing 2 or 3 amino acid residues selected from Gly, Leu, Ile, and Thr;
          D is a peptide fragment containing from 1 to 12 residues of any amino acid; and
          Tc is a carboxy terminal residue selected from OH, (C₁-C₆)alkoxy, amino, mono- or di-(C₁-C₄)alkyl substituted amino, and benzylamino.