公开(公告)号：EP0910576A2

公开(公告)日：1999-04-28

申请号：EP97915236.0

申请日：1997-04-10

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： CULLIS, Pieter, R. ,  CHOI, Lewis, S., L. ,  MONCK, Myrna ,  BAILEY, Austin

IPC分类号： A61K9 ,  C07K7 ,  C07K14

CPC分类号： C07K7/08 ,  A61K9/1271 ,  A61K9/1272 ,  C07K14/001 ,  C07K14/005 ,  C12N2760/16022

摘要： The present invention relates to liposomes and virosomes and, more particularly, to liposomal and virosomal delivery systems for transporting materials such as drugs, nucleic acids and proteins.

公开(公告)号：EP0792142A1

公开(公告)日：1997-09-03

申请号：EP95932595.0

申请日：1995-10-02

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： HOLLAND, John, W. ,  MADDEN, Thomas, D. ,  CULLIS, Pieter, R.

IPC分类号： A61K9 ,  A61K47 ,  B01J13

CPC分类号： A61K9/1272 ,  Y10T428/2984

摘要： The present invention provides a fusogenic liposome comprising a lipid capable of adopting a non-lamellar phase, yet capable of assuming a bilayer structure in the presence of a bilayer stabilizing component; and a bilayer stabilizing component reversibly associated with the lipid to stabilize the lipid in a bilayer structure. Such fusogenic liposomes are extremely advantageous because the rate at which they become fusogenic can be not only predetermined, but varied as required over a time scale ranging from minutes to days. Control of liposome fusion can be achieved by modulating the chemical stability and/or exchangeability of the bilayer stabilizing component(s). The fusogenic liposomes of the present invention can be used to deliver drugs, peptide, proteins, RNA, DNA or other bioactive molecules to the target cells of interest.

公开(公告)号：EP3394080A1

公开(公告)日：2018-10-31

申请号：EP16877035.2

申请日：2016-12-22

申请人： The University of British Columbia

发明人： CIUFOLINI, Marco, A. ,  CULLIS, Pieter, R. ,  TAM, Yuen, Yi ,  ZAIFMAN, Joshua

IPC分类号： C07J5/00 ,  A61K47/54 ,  A61P35/00 ,  A61P37/06 ,  C07D295/185 ,  C07D305/14 ,  C07D487/04 ,  C07J41/00 ,  C07J43/00

CPC分类号： C07D295/185 ,  C07D305/14 ,  C07D475/08 ,  C07D487/04 ,  C07J5/0038 ,  C07J5/0076 ,  C07J31/006 ,  C07J41/005 ,  C07J43/003

摘要： This invention provides lipid-linked prodrugs having structures as set out herein. Uses of such lipid-linked prodrug compounds for treatment of various indications, and methods for making and using lipid-linked prodrugs are also provided.

公开(公告)号：EP2224912B1

公开(公告)日：2016-05-11

申请号：EP08866209.3

申请日：2008-12-31

申请人： TEKMIRA Pharmaceuticals Corporation ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  Alnylam Pharmaceuticals

发明人： HOPE, Michael, J. ,  SEMPLE, Sean, C. ,  CHEN, Jianxin ,  MADDEN, Thomas, D. ,  MUI, Barbara ,  CULLIS, Pieter, R. ,  CIUFOLINI, Marco, A. ,  WONG, Kim, F. ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  SRINIVASULU, Masunu

IPC分类号： A61K9/127 ,  A61K31/7088 ,  C07D317/28 ,  C07C229/30

CPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K9/1275 ,  C07C215/10 ,  C07C217/08 ,  C07C217/28 ,  C07C219/08 ,  C07C229/12 ,  C07C271/12 ,  C07C323/25 ,  C07D317/28

公开(公告)号：EP2350043B9

公开(公告)日：2014-08-20

申请号：EP09819991.2

申请日：2009-10-09

申请人： TEKMIRA Pharmaceuticals Corporation ,  The University of British Columbia

发明人： HOPE, Michael, J. ,  SEMPLE, Sean, C. ,  CHEN, Jianxin ,  MADDEN, Thomas, D. ,  CULLIS, Pieter, R. ,  CIUFOLINI, Marco, A. ,  MUI, Barbara

IPC分类号： C07D345/00 ,  C07D517/00 ,  A61K9/127

CPC分类号： A61K47/22 ,  A61K9/1271 ,  A61K31/713 ,  A61K39/39 ,  A61K2039/55511 ,  C07D317/28 ,  C07D319/06

公开(公告)号：EP1328254A2

公开(公告)日：2003-07-23

申请号：EP01983342.5

申请日：2001-10-25

申请人： The University of British Columbia ,  Inex Pharmaceuticals Corp.

发明人： CULLIS, Pieter, R. ,  MACLACHLAN, Ian ,  FENSKE, David, B.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272

摘要： The present invention provides lipid-based systemic delivery vehicles and method for selectively targeting an active agent to a specific tissue site. The methods include designing a lipid-based systemic delivery vehicle having a plurality of constitutent parts, and thereafter varying the amounts of each of the plurality of constituent parts to impart tissue selectivity. After tissue selectivity is imparted it is possible to selectively target an active agent to a specific tissue site.

公开(公告)号：EP0792142B1

公开(公告)日：2001-12-05

申请号：EP95932595.2

申请日：1995-10-02

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： HOLLAND, John, W. ,  MADDEN, Thomas, D. ,  CULLIS, Pieter, R.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272 ,  Y10T428/2984

公开(公告)号：EP0812186B1

公开(公告)日：2001-10-31

申请号：EP96902842.2

申请日：1996-02-27

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： HOPE, Michael ,  CULLIS, Pieter, R. ,  FENSKE, David ,  WONG, Kim

IPC分类号： A61K9/127

CPC分类号： A61K9/1278

摘要： Methods for the preparation of stable liposome formulations of protonatable therapeutic agents. The methods involve loading a therapeutic agent into preformed liposomes having a methylamine concentration gradient across the lipid bilayer of the liposomes. These methods provide liposome formulations which are more stable, more cost effective, and easier to prepare in a clinical environment than those previously available. The present invention also provides the pharmaceutical compositions prepared by the above methods, a kit for the preparation of liposome formulations of therapeutic agents, and methods for their use.

公开(公告)号：EP0812186A1

公开(公告)日：1997-12-17

申请号：EP96902842.0

申请日：1996-02-27

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： HOPE, Michael ,  CULLIS, Pieter, R. ,  FENSKE, David ,  WONG, Kim

IPC分类号： A61K9

CPC分类号： A61K9/1278

摘要： Methods for the preparation of stable liposome formulations of protonatable therapeutic agents. The methods involve loading a therapeutic agent into preformed liposomes having a methylamine concentration gradient across the lipid bilayer of the liposomes. These methods provide liposome formulations which are more stable, more cost effective, and easier to prepare in a clinical environment than those previously available. The present invention also provides the pharmaceutical compositions prepared by the above methods, a kit for the preparation of liposome formulations of therapeutic agents, and methods for their use.