-
11.发明公开
公开(公告)号：EP2158183A2
公开(公告)日：2010-03-03
申请号：EP08769547.4
申请日：2008-05-21
发明人： MARTINBOROUGH, Esther , NEUBERT, Timothy , WHITNEY, Tara , LEHSTEN, Danielle , HAMPTON, Tara , ZIMMERMANN, Nicole , TERMIN, Andreas
IPC分类号： C07C311/58 , C07C311/59 , C07C311/60 , C07C311/51 , C07C311/53 , A61K31/18 , C07D215/18
CPC分类号： C07D209/08 , C07C311/51 , C07C311/53 , C07C2602/08 , C07D209/42 , C07D215/06 , C07D215/233 , C07D317/60 , C07D401/04 , C07D401/06 , C07D405/12
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现已发现本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道的抑制剂。
-
公开(公告)号：EP1608632B1
公开(公告)日：2009-12-30
申请号：EP04716887.7
申请日：2004-03-03
发明人： GONZALES, Jesus, E., III , WILSON, Dean, Mitchell , TERMIN, Andreas, Peter , GROOTENHUIS, Peter, Diederik, Jan , ZHANG, Yulian , PETZOLDT, Benjamin, John , FANNING, Lev, Tyler, Dewey , NEUBERT, Timothy, Donald , TUNG, Roger, D. , MARTINBOROUGH, Esther , ZIMMERMANN, Nicole
IPC分类号： C07D239/94 , C07D403/04 , C07D413/12 , A61K31/517 , C07D401/12 , C07D401/04 , C07D403/12 , C07D401/14 , C07D405/12 , C07D403/14 , C07D417/12 , C07D409/14 , C07D417/14 , C07D409/12 , C07D471/04
CPC分类号： C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R1, X, R3, x, and ring A are as defined in the present application.
-
公开(公告)号：EP1948597A1
公开(公告)日：2008-07-30
申请号：EP06836469.4
申请日：2006-10-23
发明人： MARTINBOROUGH, Esther , TERMIN, Andreas, P. , NEUBERT, Timothy, D. , ZIMMERMANN, Nicole , GUTIERREZ, Corey, Don
IPC分类号： C07D207/12 , C07D211/54 , C07D401/08 , C07D401/12 , C07D403/08 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/4523 , A61P25/00
CPC分类号： C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要： Sulfonamide derivatives act as ion channel antagonists. These compounds have the general Formula (I): Formula (I) compositions are useful for treating or relieving pain-related conditions.
-
14.发明公开
公开(公告)号：EP1809290A2
公开(公告)日：2007-07-25
申请号：EP05851346.6
申请日：2005-11-03
发明人： MARTINBOROUGH, Esther , ZIMMERMANN, Nicole , PERNI, Robert , ARNOST, Michael , BANDARAGE, Upul , MALTAIS, Francois , BEMIS, Guy
IPC分类号： A61K31/506 , C07D401/12 , C07D403/06 , C07D405/12 , C07D403/12 , C07D409/12 , C07D403/04 , C07D239/30 , C07D405/14 , C07D413/06 , C07D413/04 , A61P25/28
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
-
公开(公告)号：EP1608632A1
公开(公告)日：2005-12-28
申请号：EP04716887.7
申请日：2004-03-03
发明人： GONZALES, Jesus, E., III , WILSON, Dean, Mitchell , TERMIN, Andreas, Peter , GROOTENHUIS, Peter, Diederik, Jan , ZHANG, Yulian , PETZOLDT, Benjamin, John , FANNING, Lev, Tyler, Dewey , NEUBERT, Timothy, Donald , TUNG, Roger, D. , MARTINBOROUGH, Esther , ZIMMERMANN, Nicole
IPC分类号： C07D239/94 , C07D403/04 , C07D413/12 , A61K31/517 , C07D401/12 , C07D401/04 , C07D403/12 , C07D401/14 , C07D405/12 , C07D403/14 , C07D417/12 , C07D409/14 , C07D417/14 , C07D409/12 , C07D471/04
CPC分类号： C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R1, X, R3, x, and ring A are as defined in the present application.
-
-
-
-
搜索结果
15 条记录 (耗时 0.022 秒)
