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公开(公告)号：EP2201008A1
公开(公告)日：2010-06-30
申请号：EP08831349.9
申请日：2008-09-19
IPC分类号： C07D417/14 , A61K31/33 , A61P25/00
CPC分类号： C07D417/14
摘要： The present invention relates to pyridyl sulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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2.发明公开
公开(公告)号：EP1638955A2
公开(公告)日：2006-03-29
申请号：EP04777512.7
申请日：2004-07-02
发明人： WILSON, Dean, Mitchell , MARTINBOROUGH, Esther , NEUBERT, Timothy, Donald , TERMIN, Andreas, Peter , GONZALES, Jesus, E., III , ZIMMERMANN, Nicole
IPC分类号： C07D401/12 , C07D403/12 , C07D239/42 , C07D403/04 , C07D239/48 , C07D405/04 , C07D401/04 , C07D409/04 , C07D405/12 , C07D413/04 , A61K31/506 , A61P29/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要： The present invention relates to compounds of formula (I) useful as inhibitors of voltage-gated ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP1776106A1
公开(公告)日：2007-04-25
申请号：EP05763777.9
申请日：2005-06-22
发明人： TERMIN, Andreas P. , MARTINBOROUGH, Esther , ZIMMERMANN, Nicole , COHEN, Charles J. , GUTIERREZ, Corey Don
IPC分类号： A61K31/381 , A61K31/404 , A61K31/343 , A61P29/00 , A61P25/08 , A61P19/00 , A61P25/14
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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公开(公告)号：EP1678145A2
公开(公告)日：2006-07-12
申请号：EP04796881.3
申请日：2004-10-28
发明人： WILSON, Dean, M. , TERMIN, Andreas, P. , GONZALEZ, Jesus, E. III , ZIMMERMANN, Nicole , ZHANG, Yulian , FANNING, Lev, T. D.
IPC分类号： C07D235/18 , C07D401/04 , C07D403/04 , C07D209/14 , A61K31/415 , A61K31/33
CPC分类号： C07D405/12 , C04B35/632 , C07D209/42 , C07D235/14 , C07D235/18 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of suing the compositions in the treatment of various disorders.
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5.发明授权4(-3-(-2-(PHENYL)MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL)BENZENESULFONAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN 有权4-（3-（2-（苯基）吗啉代）-2-氧代吡咯烷-1-基）-N-（噻唑-2-基）苯磺酰胺和相关化合物作为离子通道调节剂来治疗疼痛
公开(公告)号：EP2231655B1
公开(公告)日：2011-08-31
申请号：EP08850039.2
申请日：2008-11-12
发明人： STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi, Michel Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , KAWATKAR, Aarti, Sameer
IPC分类号： C07D417/14 , A61K31/427 , A61P25/04
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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6.发明公开4(-3-(-2-(PHENYL)MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL)BENZENESULFONAMIDE DERIVATI VES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN 有权4-（3-（2-（苯基）吗啉代）-2-氧代吡咯烷-1-基）-N-（噻唑-2-基）苯磺酰胺和相关化合物作为离子通道调节剂来治疗疼痛
公开(公告)号：EP2231655A2
公开(公告)日：2010-09-29
申请号：EP08850039.2
申请日：2008-11-12
发明人： STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi, Michel Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , KAWATKAR, Aarti, Sameer
IPC分类号： C07D417/14 , A61K31/427 , A61P25/04
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP1776106B1
公开(公告)日：2013-08-07
申请号：EP05763777.9
申请日：2005-06-22
发明人： TERMIN, Andreas P. , MARTINBOROUGH, Esther , ZIMMERMANN, Nicole , COHEN, Charles J. , GUTIERREZ, Corey Don
IPC分类号： A61K31/405 , A61K31/404 , A61K31/381 , A61K31/343 , A61P29/00 , A61P25/08 , A61P19/00 , A61P25/14
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
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公开(公告)号：EP2220080B1
公开(公告)日：2012-01-04
申请号：EP08848685.7
申请日：2008-11-12
发明人： STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi Michel, Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , HAMPTON, Tara, Leanne
IPC分类号： C07D417/14 , A61K31/4427 , A61K31/427
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP2307412A2
公开(公告)日：2011-04-13
申请号：EP09774406.4
申请日：2009-07-01
发明人： ZIMMERMANN, Nicole , GROOTENHUIS, Peter, D.J. , NUMA, Mehdi, Michel, Djamel , STAMOS, Dean , ANDERSON, Corey, Don , WHITNEY, Tara
IPC分类号： C07D471/04 , A61K31/436 , A61P35/00
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP2220080A2
公开(公告)日：2010-08-25
申请号：EP08848685.7
申请日：2008-11-12
发明人： STAMOS, Dean , MARTINBOROUGH, Esther , NEUBERT, Timothy , NUMA, Mehdi Michel, Djamel , WHITNEY, Tara , ZIMMERMANN, Nicole , HAMPTON, Tara, Leanne
IPC分类号： C07D417/14 , A61K31/4427 , A61K31/427
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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