公开(公告)号：EP2385833A1

公开(公告)日：2011-11-16

申请号：EP10704436.4

申请日：2010-01-07

申请人： Scynexis, Inc.

发明人： HOPKINS, Samuel, Earl

IPC分类号： A61K31/7068 ,  A61K38/13 ,  A61P31/12

CPC分类号： A61K38/13 ,  A61K31/7068 ,  A61K2300/00

摘要： This invention relates to combinations comprising 3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]- 4-(gammahydroxymethylleucine)cyclosporine, or a pharmaceutically acceptable salt, solvate or hydrate thereof; and certain nucleoside analogues, and their use in the treatment of hepatitis C virus.

公开(公告)号：EP2473169B1

公开(公告)日：2019-03-20

申请号：EP10814329.8

申请日：2010-08-30

申请人： Scynexis, Inc.

发明人： POLLARD, Jennifer, M. ,  CHMIELOWSKI, Rebecca, A. ,  DEITRICH, Lisa, M. ,  GAILLIOT, Francis, P. ,  GOKLEN, Kent

IPC分类号： C07J71/00 ,  C07H15/256

公开(公告)号：EP2663322A4

公开(公告)日：2014-06-25

申请号：EP12734728

申请日：2012-01-12

申请人： SCYNEXIS INC

发明人： SCORNEAUX BERNARD ,  HOPKINS SAMUEL EARL ,  RIBEILL YVES JOSEPH

IPC分类号： A61K38/13 ,  A61P31/14

CPC分类号： A61K38/13 ,  A61K38/14 ,  C12Q1/707 ,  C12Q2600/106 ,  C12Q2600/156

摘要： Methods of predicting the response in a patient infected with hepatitis C virus (HCV) to a treatment regime involving the use of a cyclophilin-binding compound are described which provide for improvements in treatments, pharmaceutical compositions, dosing regimen, assays, kits, and other aspects of the art.

公开(公告)号：EP2326180B1

公开(公告)日：2013-10-16

申请号：EP09806946.1

申请日：2009-08-10

申请人： Merck Sharp & Dohme Corp. ,  Scynexis, Inc.

发明人： GREENLEE, Mark, L. ,  WILKENING, Robert ,  APGAR, James ,  SPERBECK, Donald ,  WILDONGER, Kenneth, James ,  MENG, Dongfang ,  PARKER, Dann, L., Jr. ,  MAMAI, Ahmed

IPC分类号： A01N43/64 ,  A61K31/21 ,  A61K31/41

CPC分类号： A61K31/21 ,  A61K31/41 ,  C07D405/04

公开(公告)号：EP2519538A1

公开(公告)日：2012-11-07

申请号：EP10799265.3

申请日：2010-12-30

申请人： Scynexis, Inc.

发明人： OGBU, Cyprian, Okwara ,  RICHARDSON, Thomas, Edward

IPC分类号： C07K7/64 ,  A61P31/12

CPC分类号： C07K7/645 ,  A61K38/00

摘要： The invention relates to the use of cyclic compounds of general formula (I): wherein A, B, R
1 and R
2 are as defined in the specification, and their use as pharmaceuticals, e.g. in the treatment of HCV infections. In particular, • R
1 is selected from hydrogen, alkyl, alkenyl, XR
3 ; • R
2 is selected from alkyl, alenyl, alkynyl, cycloalkyl, all of which can be optionally substituted; • R
3 is selected from the same moieties of R
2 , plus alkoxycarbonyl. The preferred compounds are cyclosporine analogues carrying an ether functionality on the side chain of Leu-4.

公开(公告)号：EP1802650A4

公开(公告)日：2008-08-20

申请号：EP05815625

申请日：2005-09-30

申请人： SCYNEXIS INC

发明人： FLIRI HANS GEORG ,  HOUCK DAVID RENWICK

IPC分类号： C07K7/64 ,  A61P31/14

CPC分类号： A61K38/13 ,  C07K7/645

公开(公告)号：EP1931696A1

公开(公告)日：2008-06-18

申请号：EP06816230.4

申请日：2006-10-02

申请人： Scynexis, Inc.

发明人： HOUCK, David, Renwick ,  LI, Keqiang

IPC分类号： C07K7/64 ,  A61K38/13 ,  A61P31/00

CPC分类号： C07K7/645

摘要： This invention provides compounds of general formula (I): (I) wherein A, B, R 1 , R2, and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus and/or human immunodeficiency virus.

公开(公告)号：EP1159063B1

公开(公告)日：2005-08-24

申请号：EP00907620.9

申请日：2000-02-11

申请人： Scynexis, Inc.

发明人： RIBEILL, Yves ,  MONNET, Pierre ,  ABEDI, Jaleh, Azmi ,  SMITH, Henry, David, III ,  MCCOMB, Susan, Marie

IPC分类号： B01J19/00 ,  B01L3/00 ,  B01L9/06

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00452 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00693 ,  B01J2219/00698 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00745 ,  B01J2219/00754 ,  C40B40/10 ,  C40B40/14 ,  C40B40/18 ,  C40B50/08 ,  C40B70/00 ,  G01N35/028 ,  G01N2035/00217

摘要： Devices and processes for synthesizing, purifying and analyzing large numbers of compounds for use in combinatorial libraries, are disclosed. The processes involve generating a series of compounds in multi-well plates or multi-tube racks, purifying the reaction mixtures, analyzing the purified compounds, and optionally performing bioassays on the compounds. The information regarding the compounds is stored in a central database. The devices include one or more multi-tube configurations, a purification device, means for transferring the contents of the tubes, a solvent evaporator, analytical instrumentation, and, optionally a weighing instrument. The multi-tube configuration(s) optionally include a cover, which can be placed on or removed from the configuration by computer control. By correlating the orientation of tubes from one stage to the next, it is possible to use a single bar code or other identifying mark for each multi-tube configuration rather than for each individual tube. This simplifies data collection for large numbers of compounds. An interface also described herein permits one to use racks from one vendor and other components from other vendors.

公开(公告)号：EP3661503B1

公开(公告)日：2022-09-07

申请号：EP18755632.9

申请日：2018-07-31

发明人： ANGULO GONZALEZ, David A.

IPC分类号： A61K31/4196 ,  A61K31/4439 ,  A61P31/10 ,  A61P15/02

公开(公告)号：EP3735226B1

公开(公告)日：2022-08-10

申请号：EP18834263.8

申请日：2018-12-21

发明人： MOTHERAM, Rajeshwar

IPC分类号： A61K9/127 ,  A61K31/4196