公开(公告)号：EP3074424A1

公开(公告)日：2016-10-05

申请号：EP14866161.4

申请日：2014-11-27

申请人： Zymeworks Inc.

发明人： WEISSER, Nina E. ,  NG, Gordon Yiu Kon ,  WICKMAN, Grant Raymond ,  DIXIT, Surjit Bhimarao ,  ESCOBAR-CABRERA, Eric ,  SANCHES, Mario

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K16/28 ,  C12N15/13 ,  C12N5/10 ,  C40B40/08

CPC分类号： C07K16/32 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492

摘要： Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.

摘要翻译： 本文提供了特异性结合HER2的二互补位的抗原结合构建体。 双互补位抗原结合构建体包含结合HER2的ECD2的一个抗原结合部分，其结合HER2的ECD4的第二抗原结合部分和Fc。 至少一个抗原结合部分是scFv。 两性反应性抗原结合构建体可用于治疗癌症。

公开(公告)号：EP2906237A4

公开(公告)日：2016-10-05

申请号：EP13816831

申请日：2013-07-12

申请人： ZYMEWORKS INC

发明人： DIXIT SURJIT BHIMARAO ,  D ANGELO IGOR EDMONDO PAOLO ,  SANCHES MARIO ,  NG GORDON YIU KON

IPC分类号： C07K16/46 ,  A61K39/395 ,  C07K14/76 ,  C07K16/28

CPC分类号： C07K14/76 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2319/00 ,  C07K2319/31

公开(公告)号：EP2504776A4

公开(公告)日：2015-08-19

申请号：EP10832469

申请日：2010-11-23

申请人： ZYMEWORKS INC

发明人： RODINGER TOMAS ,  LARIO PAULA I

IPC分类号： G06F17/30 ,  G06F19/00 ,  G06F19/24

CPC分类号： G06F17/30598 ,  G06F17/30657 ,  G06F17/30867 ,  G06F19/18 ,  G06F19/24

摘要： A new density based clustering method for clustering data points in multidimensional space is described. Each point has a neighborhood consisting of all points that are within a preset cutoff radius or distance. Each point is assigned a density measure based on the number of points in its neighborhood. Any point that has a higher density than any of its neighboring points is the center of a cluster and is assigned a unique cluster ID. Every other point follows a path through the graph of neighboring points such that density is increasing as fast as possible until a cluster center is reached. The algorithm's performance is demonstrated on a one-dimensional, two-dimensional, and 18-dimensional dataset.

公开(公告)号：EP2847230A1

公开(公告)日：2015-03-18

申请号：EP13788302.1

申请日：2013-05-10

申请人： Zymeworks, Inc.

发明人： SPRETER VON KREUDENSTEIN, Thomas ,  ESCOBAR-CABRERA, Eric ,  NG, Gordon YiuKon ,  DIXIT, Surjit Bhimarao ,  LARIO, Paula Irene ,  POON, David Kai Yuen

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61P35/00 ,  A61P37/02 ,  C07K16/12 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30

摘要： Provided herein are isolated heteromultimers comprising: at least one single domain antigen-binding construct attached to at least one monomer of a heterodimer Fc region; wherein the heterodimer Fc region comprises a variant CH3 domain comprising amino acid mutations that promote the formation of said heterodimer with stability comparable to that of a native Fc homodimer; and wherein said isolated heteromultimer is devoid of immunoglobulin light chains and optionally devoid of immunoglobulin CH1 region. These novel molecules comprise complexes of heterogeneous components designed to alter the natural way antibodies behave and that find use in therapeutics.

公开(公告)号：EP2245571A4

公开(公告)日：2015-03-18

申请号：EP09708274

申请日：2009-02-05

申请人： ZYMEWORKS INC

发明人： LARIO PAULA I ,  MULLEGGER JOHANNES ,  DIXIT SURJIT B ,  RODINGER TOMAS ,  TAN POWELL PATRICK CHENG

IPC分类号： G06F19/16 ,  C07K14/00 ,  C12N15/00 ,  C12N15/11 ,  C40B30/02 ,  G01N33/68 ,  G06F19/00

CPC分类号： G01N33/68 ,  G06F19/12 ,  G06F19/16 ,  G06F19/18 ,  G06F19/26

摘要： The invention provides methods and systems of determining biopolymer profiles and correlations between structural units (residues) of a biopolymer based on sampling of the conformational space available to the molecule. The correlations between these structural units can further be used to find networks within a biopolymer such as the coupled residue networks in a protein. The invention also provides for designing and engineering biopolymers including polypeptides, nucleic acids and carbohydrates using the information derived from the conformation clustering and subsequent methods described herein.

公开(公告)号：EP2681245A4

公开(公告)日：2015-02-18

申请号：EP12751893

申请日：2012-03-02

申请人： ZYMEWORKS INC

发明人： DIXIT SURJIT BHIMARAO ,  D ANGELO IGOR EDMONDO PAOLO ,  POON DAVID KAI YUEN

IPC分类号： C07K19/00 ,  C07K14/47 ,  C07K14/485 ,  C07K14/605 ,  C07K14/76 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30

CPC分类号： C07K14/765 ,  C07K14/47 ,  C07K14/4721 ,  C07K14/485 ,  C07K14/605 ,  C07K14/76 ,  C07K14/79 ,  C07K16/283 ,  C07K16/32 ,  C07K19/00 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/31 ,  C12N9/6454 ,  C12Y304/21061

摘要： Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.

摘要翻译： 本文提供多功能异源蛋白。 在具体实施方案中是异源多聚体，其包含：至少两种单体蛋白质，其中每个单体蛋白质包含连接到转运蛋白多肽的至少一种货物多肽，使得所述单体蛋白质缔合以形成异源多聚体。 这些治疗上新颖的分子包括用作结合或融合治疗性分子实体的支架的单体，导致产生双特异性或多价分子物质。

公开(公告)号：EP2552957A1

公开(公告)日：2013-02-06

申请号：EP11761857.9

申请日：2011-03-28

申请人： Zymeworks, Inc.

发明人： D'ANGELO, Igor ,  BLEILE, Dustin ,  TOM-YEW, Stacey A. L. ,  ESCOBAR-CABRERA, Eric ,  LARIO, Paola, I. ,  OHRN, Anders ,  POON, David K. Y. ,  DIXIT, Surjit, B.

IPC分类号： C07K16/00 ,  A61K39/395 ,  A61P35/00 ,  A61P37/00 ,  C07K19/00 ,  C12N15/13 ,  G06F19/10 ,  C07K14/735 ,  C07K16/28

CPC分类号： C07K16/32 ,  C07K14/70535 ,  C07K16/00 ,  C07K16/082 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/283 ,  C07K16/2851 ,  C07K16/2887 ,  C07K16/464 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  G06F19/16

摘要： Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.

公开(公告)号：EP3107938B1

公开(公告)日：2022-05-04

申请号：EP15799575.4

申请日：2015-05-29

发明人： SANCHES, Mario ,  SPRETER VON KREUDENSTEIN, Thomas ,  UROSEV, Dunja ,  D'ANGELO, Igor Edmondo Paolo ,  TOM-YEW, Stacey A. L. ,  DIXIT, Surjit Bhimarao ,  CORPER, Adam Louis ,  CHOU, Yang-Chieh

IPC分类号： C07K16/46 ,  A61K39/395 ,  C07K16/36 ,  C12N15/13 ,  C07K16/28 ,  C07K16/32

公开(公告)号：EP2773671B1

公开(公告)日：2021-09-15

申请号：EP12845801.5

申请日：2012-11-02

发明人： SPRETER VON KREUDENSTEIN, Thomas ,  DIXIT, Surjit Bhimarao ,  ESCOBAR-CABRERA, Eric ,  POON, David Kai Yuen ,  LARIO, Paula Irene

IPC分类号： C07K16/46 ,  A61K39/395 ,  A61P35/00 ,  A61P37/02 ,  C07K16/32 ,  G16B5/00

公开(公告)号：EP2994164B1

公开(公告)日：2020-08-05

申请号：EP14794897.0

申请日：2014-05-08

申请人： Zymeworks Inc.

发明人： NG, Gordon, Yiu Kon ,  CHAN, Peter, Wing Yiu ,  WICKMAN, Grant, Raymond

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/32