Abstract:
The present invention provides a passive inhaler for use in treating a number of diseases. The inventor has shown that the compositions comprised in the inhaler can be delivered to the lungs and to the brain in pharmacological relevant dosages, to treat a number of diseases in the lungs and the brain. Further, the inhaler is also able to deliver substances to the brain which may enhance transport across the blood brain barrier.
Abstract:
A container, a nebulizer and a use of an indicator device are described, where the container comprises an indicator device fixedly mounted on the bottom of the container, the container is arranged within the nebulizer and the container can be detached by grabbing the indicator device.
Abstract:
The invention relates to a powder inhaler and to a powder inhaler set that contains the powder inhaler. The powder inhaler comprises two half-shells (3, 4), which can be or are articulated to each other and which enclose an air inlet region, a powder deposition region and powder release region, and an outlet region in a joined arrangement, through which regions a fluid path extends. At least one of the half shells (3, 4) has at least one air inlet opening (8) in the air inlet region, and at least one air-swirling structure (5) is present in the air inlet region, which air-swirling structure defines the fluid path between the at least one air inlet opening (8) and the powder deposition and release region. Furthermore, one of the half-shells (3, 4) has at least one powder-accommodating recess (9) in the powder deposition region and powder release region, while the outlet region has at least one deagglomeration structure (17, 17') and an outlet for aerosol, which outlet is formed by the half-shells (3, 4).
Abstract:
The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.
Abstract:
A blister piercing element for puncturing the lid of a blister containing a dose of medicament for inhalation by a user is disclosed. It comprises a body having a surface and an opening in the surface for the passage of air, or for the passage of medicament entrained in air, through the body. The body includes a pair of spaced cutting teeth upstanding from the surface in spaced side-by-side relation, each cutting tooth projecting in cantilevered form over said opening and each having a distal cutting edge at a free end remote from said surface. The distal cutting edge of each tooth is configured to initiate a slit in a blister lid when pressure is applied to a blister lid by the teeth and the teeth are spaced from each other so that separate slits cut by the distal cutting edge of each tooth propagate in a direction toward each other between the teeth as the teeth continue to penetrate a blister lid. The pair of spaced cutting teeth form a single slit in a blister lid that defines a single flap which is folded into the blister by the teeth.
Abstract:
The present invention relates to devices for storing and delivering medicament. A device (100) according to an embodiment of the present invention comprises an air path (103) and a chamber (101) configured for storing and delivering a medicament. The chamber has a substantially curved interior surface and an opening (111) that provides fluid communication with the air path. The opening includes an inlet admitting air from the air path and an outlet for medicament entrained air to exit into the air path. A section of the curved interior surface is configured to redirect at least a portion of the inlet flow toward the inlet flow of air. So configured, some of the redirected flow of air may exit the chamber through the outlet and into the air path while other portions of the redirected flow of air recirculates about the chamber.
Abstract:
An inhaler is provided which comprises a housing to receive a strip comprising a plurality of blisters having pierceable lids and containing medicament for inhalation; a mouthpiece mounted to the housing through which the medicament is inhaled by a user; a piercing element; an actuator for moving the blisters sequentially into alignment with the piercing element and for subsequently causing the piercing element to pierce the lid of the aligned blister so that when the user inhales through the mouthpiece, an airflow is generated through the blister to entrain the medicament and carry it, via the mouthpiece, into the user's airway; and a mechanism for applying a biasing force to the actuator; wherein the mechanism is adapted to apply a biasing force to the actuator during a forward stroke which is independent of the biasing force that it applies to the actuator during a return stroke.
Abstract:
Improvement of powder inhaler, consisting of a base housing (1), snap-in capsule receptacle (2) and a moveable mouthpiece (4), this latter internally including a device (7) to open the capsule (7) containing the powdered medication, housed in a breakdown chamber (10), with air intake points (11 and 12) and an outlet (14) for air mixed with powder, with the outlet (14) being integrated with the conduit (9) of the mouthpiece (4); the above- mentioned passage (14) for the air / powder mixture located between the conduit (9) and the chamber (10) is restricted and is sufficiently long to cause two effects in the capsule (C) while it spins in the chamber (10) during inhalation: a) valve - obstruction of the passage (14) by the capsule (C), more precisely by its cylindrical part, briefly and intermittently, with such obstruction of the passage (14) being repeated at every half turn (180°) of the capsule or whenever it is aligned with the passage (14); and b) impact of the capsule (C) through suction against the roof of the breakdown chamber (10) whenever it is aligned with the passage (14) and its obstruction is complete, with this impact being sufficient to neutralize the compaction of the powder at the ends of the capsule (C) during its rotation.