公开(公告)号：EP2351765A3

公开(公告)日：2012-02-22

申请号：EP10185703.5

申请日：2002-07-10

申请人： Lakewood-Amedex, Inc

发明人： Dale, Roderic ,  Arrow, Amy ,  Thompson, Terry

IPC分类号： C07H21/04 ,  A61K48/00 ,  C12N15/00

CPC分类号： C12N15/1137 ,  A61K8/606 ,  A61K38/00 ,  A61K2800/74 ,  A61Q19/00 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2320/35 ,  C12Y101/01088 ,  C12Y103/99005 ,  C12Y111/01006 ,  C12Y113/11012 ,  C12Y114/99001 ,  C12Y203/01026 ,  C12Y203/01085 ,  C12Y301/01003 ,  C12Y301/03048 ,  C12Y304/1401 ,  C12Y304/15001 ,  C12Y304/24011 ,  C12Y306/0301 ,  C12Y604/01002 ,  C12N2310/3521

摘要： The present invention related to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.

公开(公告)号：EP2173358A4

公开(公告)日：2011-12-07

申请号：EP08771759

申请日：2008-06-23

申请人： ISIS PHARMACEUTICALS INC

发明人： BHAT BALKRISHEN ,  PRAKASH THAZHA P ,  ALLERSON CHARLES ,  KINBERGER GARTH A ,  MARCUSSON ERIC G ,  SWAYZE ERIC E

IPC分类号： A61K31/70 ,  C12N15/00 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3515 ,  C12N2310/3525 ,  C12N2310/3533 ,  C12N2320/51 ,  C12Y301/03048 ,  C12N2310/3521

公开(公告)号：EP2365094A1

公开(公告)日：2011-09-14

申请号：EP10176164.1

申请日：2002-05-13

申请人： Isis Pharmaceuticals, Inc.

发明人： Cowsert, Lex, M. ,  Wyatt, Jacqueline ,  Freier, Susan, M. ,  Monia, Brett, P. ,  Butler, Madeline, M. ,  McKay, Robert

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12N15/63 ,  A01N43/04 ,  C07H21/02 ,  C07H21/04 ,  C07H21/00 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12Y301/03048 ,  Y02P20/582 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。

公开(公告)号：EP2357235A2

公开(公告)日：2011-08-17

申请号：EP11002011.2

申请日：2006-12-07

申请人： GANYMED Pharmaceuticals AG ,  Johannes- Gutenberg-Universität Mainz

发明人： Sahin, Ugur ,  Türeci, Özlem ,  Koslowski, Michael

IPC分类号： C12N15/113 ,  A61K31/713

CPC分类号： C12N15/1138 ,  C07K14/4748 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y301/03048

摘要： The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer.

公开(公告)号：EP2128248A1

公开(公告)日：2009-12-02

申请号：EP09166406.0

申请日：2003-02-03

申请人： Life Technologies Corporation

发明人： Woolf, Tod M. ,  Taylor, Margaret F.

IPC分类号： C12N15/00 ,  A61K31/713 ,  C12N15/11

CPC分类号： C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

摘要： The present invention relates to methods of preparing oligonucleotide compositions. In particular, the invention relates to a method of making an oligonucleotide composition comprising at least two different oligonucleotides targeted to two different sequences in a target gene.

摘要翻译： 本发明涉及制备寡核苷酸组合物的方法。 特别地，本发明涉及制备寡核苷酸组合物的方法，所述寡核苷酸组合物包含靶向靶基因中两种不同序列的至少两种不同寡核苷酸。

公开(公告)号：EP2003207A3

公开(公告)日：2009-03-18

申请号：EP08008871.9

申请日：2001-01-04

申请人： Isis Pharmaceuticals, Inc.

发明人： Cowsert, Lex, M. ,  Wyatt, Jacqueline, R.

IPC分类号： C12N15/88 ,  C12N15/11 ,  C12Q1/68 ,  C07H21/04 ,  A61K31/713

CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y301/03048 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.

公开(公告)号：EP1478656A4

公开(公告)日：2008-05-07

申请号：EP03707687

申请日：2003-02-03

申请人： SEQUITUR INC

发明人： WOOLF TOD M ,  TAYLOR MARGARET F

IPC分类号： C12N15/09 ,  A61K31/713 ,  A61K48/00 ,  A61P1/04 ,  A61P9/00 ,  A61P17/06 ,  A61P27/02 ,  A61P29/00 ,  A61P31/12 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07H19/00 ,  C07H21/02 ,  C07H21/04 ,  C12N20060101 ,  C12N15/00 ,  C12N15/113

CPC分类号： C12N15/1137 ,  A61K31/713 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2320/50 ,  C12N2330/30 ,  C12Y207/11022 ,  C12Y301/03048

摘要： The present invention relates to methods of preparing oligonucleotide compositions. In particular, the invention relates to a method of making an oligonucleotide composition comprising at least two different oligonucleotides targeted to two different sequences in a target gene.

公开(公告)号：EP1560839A4

公开(公告)日：2008-04-23

申请号：EP03781746

申请日：2003-11-04

申请人： ISIS PHARMACEUTICALS INC

发明人： BAKER BRENDA F ,  ELDRUP ANNE B ,  MANOHARAN MUTHIAH ,  BHAT BALKRISHEN ,  GRIFFEY RICHARD ,  SWAYZE ERIC E ,  CROOKE STANLEY T

IPC分类号： C07H21/02 ,  C12N20060101 ,  C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1135 ,  C07H21/02 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2320/51 ,  C12Y301/03048 ,  C12N2310/3525 ,  C12N2310/3521

公开(公告)号：EP1907016A2

公开(公告)日：2008-04-09

申请号：EP06787013.9

申请日：2006-07-11

申请人： IRM, LLC

发明人： CHO, Charles ,  CHANDA, Sumit ,  SCHULTZ, Peter G.

IPC分类号： A61K48/00 ,  C12N15/11

CPC分类号： C07K14/4702 ,  A61K48/00 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12Y301/03048

摘要： The invention provides methods for modulating insulin signaling pathway and methods for treating insulin resistance. The methods employ agents which modulate FOXO1 subcellular localization. The invention also provides methods of screening for compounds that modulate insulin signaling related activities such as gluconeogenesis and cell proliferation.

公开(公告)号：EP1858557A2

公开(公告)日：2007-11-28

申请号：EP06711232.6

申请日：2006-02-23

申请人： YEDA RESEARCH AND DEVELOPMENT CO., LTD.

发明人： ELSON, Ari ,  KLINGHOFFER, Richard

IPC分类号： A61K48/00 ,  G01N33/00

CPC分类号： C12N9/16 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/53 ,  C12Y301/03048

摘要： Methods of modulating body weight and/or fat content of a subject, methods of treating or preventing weight disorders and methods of treating or preventing weight disorder related diseases are disclosed. The methods include modifying an activity or expression of a protein tyrosine phosphatase epsilon (PTPe) so as to modulate the body weight and/or fat content of the subject. Pharmaceutical compositions and articles of manufacture useful in practice of the methods are further disclosed.