公开(公告)号：EP2612751A2

公开(公告)日：2013-07-10

申请号：EP13156510.3

申请日：2007-11-05

申请人： Trustees of Tufts College

发明人： Kaplan, David ,  Omenetto, Fiorenzo ,  Lawrence, Brian ,  Cronin-Golumb, Mark ,  Georgakoudi, Irene

IPC分类号： B29D11/00

CPC分类号： C07K14/43586 ,  B29C39/02 ,  B29D11/00663 ,  B29D11/0074 ,  B82Y20/00 ,  D01F4/02 ,  D10B2211/04 ,  D10B2401/20 ,  G01N33/5436 ,  G01N33/54373 ,  G01N33/54386 ,  G01N33/544 ,  G01N2333/43578 ,  G02B1/005 ,  G02B1/04 ,  G02B1/041 ,  G02B1/045 ,  G02B1/046 ,  G02B1/06 ,  G02B5/18 ,  G02B6/138 ,  G02B2006/12102 ,  G02B2006/12104 ,  G02B2006/12107 ,  G02B2006/1213 ,  G02B2006/12171

摘要： A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.

摘要翻译： 制造生物聚合物光波导的方法包括提供生物聚合物，逐渐展开生物聚合物以提取单独的生物聚合物纤维，并将展开的纤维置于张力下。 然后将张紧的纤维浇铸在不同的聚合物中以形成生物聚合物光波导，该生物聚合物光波导由于生物聚合物与不同聚合物之间折射率的差异而引导光。 光纤可用于生物医学应用，并可作为透射介质插入身体内。 印刷技术可用于制造生物聚合物光波导。

公开(公告)号：EP2480343A1

公开(公告)日：2012-08-01

申请号：EP10819626.2

申请日：2010-09-27

申请人： N3D Biosciences, Inc.

发明人： SOUZA, Glauco R.

IPC分类号： B05D5/12 ,  H01F1/04

CPC分类号： C12N5/0062 ,  B03C1/015 ,  B03C1/30 ,  B03C2201/26 ,  B82Y25/00 ,  C12N5/00 ,  C12N2513/00 ,  C12N2529/00 ,  C12N2531/00 ,  C12N2533/10 ,  C12N2533/32 ,  G01N33/54326 ,  G01N33/544 ,  G01R33/1269 ,  H01F1/0045 ,  H01F1/0063 ,  H01F1/083 ,  H01F1/113 ,  H01F1/445 ,  Y10S977/773 ,  Y10S977/89 ,  Y10S977/904 ,  Y10S977/923

摘要： A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.

摘要翻译： 包含正带负电的纳米颗粒的材料，其中所述纳米颗粒中的一个包含磁响应元件，与作为磁性纳米颗粒组件的长天然或合成分子或聚合物的支撑分子组合。 当磁性纳米颗粒组件与细胞组合时，它将磁化这些细胞。 然后可以洗涤磁化的细胞以除去磁性纳米颗粒组件，并且在磁场中操纵磁化的细胞。

公开(公告)号：EP2270506A3

公开(公告)日：2011-03-09

申请号：EP10166674.1

申请日：2010-06-21

申请人： Amic AB

发明人： Mendel-Hartvig, Ib ,  Rundström, Gerd

IPC分类号： G01N33/532 ,  G01N33/544 ,  G01N33/58

CPC分类号： G01N33/532 ,  G01N33/544 ,  G01N33/58

摘要： A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, said macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label are bound.

公开(公告)号：EP2270506A2

公开(公告)日：2011-01-05

申请号：EP10166674.1

申请日：2010-06-21

申请人： Amic AB

发明人： Mendel-Hartvig, Ib ,  Rundström, Gerd

IPC分类号： G01N33/532 ,  G01N33/544 ,  G01N33/58

CPC分类号： G01N33/532 ,  G01N33/544 ,  G01N33/58

摘要： A conjugate, for use as a detection reagent in an immunoassay, is based on a hydrophilic monodisperse macromolecule, i.e. a macromolecule having a substantially uniform size and shape, said macromolecule forming a practically useful and manageable carrier, to which carrier at least one binding entity and at least one label are bound.

摘要翻译： 用作免疫测定中的检测试剂的缀合物基于亲水性单分散性大分子，即具有基本均匀大小和形状的大分子，所述大分子形成实用有用且可管理的载体，载体上具有至少一种结合实体 并至少绑定一个标签。

公开(公告)号：EP2126576A1

公开(公告)日：2009-12-02

申请号：EP08720161.2

申请日：2008-03-13

申请人： Director General, Defence Research & Development Organisation ,  Indian Institute of Science

发明人： RAI, Ganga Prasad ,  AGARWAL, Gauri Shanker ,  RAJ, Samuel Merwyn Packia ,  SEKHAR, Krishnamurthy ,  SOOD, Ajay Kumar ,  NEGI, Ajay Singh

IPC分类号： G01N33/569 ,  G01N33/543

CPC分类号： G01N33/54313 ,  G01N33/54393 ,  G01N33/544 ,  G01N33/56916 ,  G01N2333/255 ,  Y02A50/59

摘要： The present disclosure provides a reagent for detection of analyte in a sample and process of preparation of the reagent. The reagent comprises heparin and substrate coated with the analyte-counterpart. The analyte-counterpart of the reagent is capable of binding to said analyte. The present disclosure further provides a process for detection of an analyte in a sample by contacting said sample with said reagent and detecting formation of analyte-analyte counterpart complex. The present disclosure provides a kit for detection of an analyte in a sample.

公开(公告)号：EP2006684A1

公开(公告)日：2008-12-24

申请号：EP06833308.7

申请日：2006-11-24

申请人： National University Corp. Akita Univ.

发明人： TSUJIUCHI, Yutaka

IPC分类号： G01N33/543

CPC分类号： G01N33/544 ,  B05D1/204 ,  B82Y30/00 ,  B82Y40/00

摘要： The invention addressed a difficult problem in the conventional methods and has its object to provide an organic thin film with flexibility and high strength to be a support for a molecule, with which a biomolecular element or a molecule such as a membrane protein as a biosensor can function equally in a living body, and a method for producing the same. In this invention, the organic thin film to be a support for the biomolecular element or the biosensor molecule is produced by forming a layer of lipid molecules on a layer of fatty acid molecules which is a primary thin film layer formed on an inorganic substrate. Further, by the selection and combination of fatty acid molecules, a thin film structure with a characteristic pattern structure can be obtained.

摘要翻译： 本发明解决一个难题，在传统方法中，有其目的是提供一种有机薄膜柔韧性和高强度成为一个分子的载体，利用该生物分子元件或分子：如膜蛋白作为生物传感器可以 同样的功能在活体，及其制造方法。 在本发明中，有机薄膜是用于生物分子元件或生物传感器分子的载体是由脂肪酸分子的所有的层，其是形成在无机基材的初级薄膜层上形成脂质分子层产生的。 此外，通过选择和脂肪酸分子的组合，具有特征图案结构的薄膜结构可以得到。

公开(公告)号：EP1877791A2

公开(公告)日：2008-01-16

申请号：EP05857135.7

申请日：2005-12-16

申请人： 3M Innovative Properties Company

发明人： BOMMARITO, G., Marco ,  LAKSHMI, Brinda, B.

IPC分类号： G01N33/543 ,  G01N21/29 ,  G01N33/544

CPC分类号： C12Q1/04 ,  G01N21/29 ,  G01N21/78 ,  G01N31/22 ,  G01N33/5432 ,  G01N33/544 ,  G01N33/56938 ,  G01N2333/21 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2333/75

摘要： Colorimetric sensors for detection of an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric detection of an analyte are also disclosed.

公开(公告)号：EP1845375A2

公开(公告)日：2007-10-17

申请号：EP07111462.3

申请日：2001-12-21

申请人： Bio A.R.T. BVBA

发明人： Fannes, France

IPC分类号： G01N33/52 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/558 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/544 ,  G01N33/581

摘要： The present invention relates to an assay device for testing the presence of an analyte in a given sample comprising:
a multilayer support whereon a first analyte-binding compound or analyte-binding complex, able to bind said analyte present in said sample, is immobilized, whereby said analyte is able to bind a second enzyme labeled analyte-binding compound or enzyme labeled analyte-binding complex forming a sandwich complex, whereby said sandwich complex is able to generate upon contact with a suitable precipitating substrate for said enzyme-label a colored deposit in a one step procedure. The invention also relates to a diagnostic kit or a method for the detection of an analyte in any medium.

摘要翻译： 本发明涉及在测定装置用于测试在给定的样品包含的分析物的存在：一个多层支撑其上的第一分析物结合的化合物或分析物结合复合物，能够结合所述分析物存在于所述样品中，被固定化， 由此所述分析物能够结合的第二种酶标记的分析物 - 结合的化合物或酶标记的分析物结合复合形成夹心复合物，其中所述夹心复合物能够在与所述酶标记的有色沉积物的合适的沉淀底物接触，以产生 在一步过程。 因此本发明涉及的诊断试剂盒或用于检测在任何介质中的分析物的方法。

公开(公告)号：EP1727833A1

公开(公告)日：2006-12-06

申请号：EP05716360.2

申请日：2005-03-24

申请人： Universität Stuttgart

发明人： PFIZENMAIER, Klaus ,  SCHEURICH, Peter ,  GRUNWALD, Ingo ,  KRIPPNER-HEIDENREICH, Anja

IPC分类号： C07K14/525 ,  C12N15/62 ,  C12N15/63 ,  A61K38/19

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K45/06 ,  C07K14/70575 ,  C07K16/40 ,  C07K2317/622 ,  C07K2319/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/544 ,  G01N33/6863 ,  G01N2333/525 ,  Y10S530/811 ,  Y10S530/812

摘要： The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.

公开(公告)号：EP1279959A4

公开(公告)日：2006-07-05

申请号：EP01930017

申请日：2001-05-10

申请人： TOUDAI TLO LTD

发明人： KATAOKA KAZUNORI ,  NAGASAKI YUKIO ,  OTSUKA HIDENORI ,  KANEKO MITSUHIRO

IPC分类号： G01N33/543 ,  C08G63/688 ,  C08G65/329 ,  G01N21/41 ,  G01N21/76 ,  G01N33/544 ,  G01N33/545

CPC分类号： G01N33/545 ,  C08G63/688 ,  G01N33/54353 ,  G01N33/544 ,  Y10S435/817

摘要： A polymer composition containing a polymer or copolymer which has a mercapto group at one end and a functional group or ligand at the other end and has a polyethylene glycol segment. The composition can form a biosensor surface reduced in non-specific adsorption of a protein, etc.