公开(公告)号：EP2468858A1

公开(公告)日：2012-06-27

申请号：EP10809452.5

申请日：2010-03-12

申请人： Chongqing Fagen Biomedical Inc.

发明人： FAN, Kai ,  ZHAO, Zhiquan ,  ZHANG, Chun ,  CHEN, Yong ,  LUO, Hua ,  YANG, Li ,  LIU, honghong

IPC分类号： C12N15/06 ,  C12N15/63 ,  A61K38/26 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  C07K14/50 ,  C07K14/605

CPC分类号： C07K14/50 ,  A61K38/00 ,  C07K14/605 ,  C07K2319/00

摘要： Abstract: Provided is a fusion protein, which comprises human fibroblast growth factor 21 and glucagon-lihe-peptide-1 or its analogs. Also provided is the medicament composition comprising the fusion protein, which can be used for treating or preventing obesity, diabetes, hyperglycemia and hyperlipidemia etc.

摘要翻译： 摘要：本发明提供一种融合蛋白，其包含人成纤维细胞生长因子21和胰高血糖素力合肽-1或其类似物。 所以提供了包含融合蛋白，其可用于治疗或预防肥胖，糖尿病，高血糖症和高脂血症等的药剂组合物

公开(公告)号：EP2201113A4

公开(公告)日：2011-06-22

申请号：EP08839874

申请日：2008-10-17

申请人： SNU R&DB FOUNDATION

发明人： OH UHTAEK ,  CHO HAWON ,  YANG YOUNG DUK ,  TAK MIN HO ,  JANG YONGWOO ,  KOO JAE YEON ,  CHO SI YOUNG ,  JEONG YEON SU

IPC分类号： C12N15/06

CPC分类号： G01N33/6872 ,  G01N2333/726 ,  G01N2500/10

公开(公告)号：EP1734054B1

公开(公告)日：2010-01-20

申请号：EP06000961.0

申请日：1999-08-31

申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED

发明人： Fukushima, Masakazu ,  Okabe, Hiroyuki

IPC分类号： C07K16/40 ,  C12N5/20 ,  C12N15/06 ,  G01N33/573

CPC分类号： C07K16/40

公开(公告)号：EP2082032A1

公开(公告)日：2009-07-29

申请号：EP07815345.9

申请日：2007-10-10

申请人： Biosceptre International Limited

发明人： BARDEN, Julian, Alexander ,  GIDLEY-BAIRD, Angus

IPC分类号： C12N5/20 ,  C07K16/28 ,  C07K16/30 ,  C12N15/06 ,  G01N33/53 ,  G01N33/536 ,  G01N33/563 ,  G01N33/574 ,  G01N33/577

CPC分类号： G01N33/566 ,  C07K16/28

摘要： The present invention relates to the production of anti non functional P2X7 receptor monoclonal antibodies from hybridoma cell lines.

公开(公告)号：EP1220952B1

公开(公告)日：2008-12-31

申请号：EP00968746.8

申请日：2000-10-06

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth, W. ,  YAN, Hai ,  PAPADOPOULOS, Nicholas

IPC分类号： C12Q1/68 ,  C12N15/06 ,  C12N5/26

CPC分类号： C12N5/166 ,  C12Q1/6886 ,  C12Q2600/156

摘要： Detection of mutations associated with hereditary diseases is complicated by the diploid nature of mammalian cells. Mutations present in one allele are often masked by the wild-type sequence of the other allele. Individual alleles can be isolated from every chromosome within somatic cell hybrids generated from a single fusion. Nucleic acids from the hybrids can be analyzed for mutations in an unambiguous manner. This approach was used to detect two cancer-causing mutations that had previously defied genetic diagnosis. One of the families studied, Warthin Family G, was the first kindred with a hereditary colon cancer syndrome described in the biomedical literature.

公开(公告)号：EP1199565B1

公开(公告)日：2008-10-08

申请号：EP00937283.0

申请日：2000-06-16

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： SHITARA, Kenya, Kyowa Hakko Koggo Co.Ltd ,  SHIBUYA, Masabumi

IPC分类号： G01N33/53 ,  A61K45/00 ,  A61K39/395 ,  C12N15/06 ,  C12N15/12 ,  C07K16/28

CPC分类号： G01N33/74 ,  G01N33/5055 ,  G01N33/56966 ,  G01N33/6893 ,  G01N2333/475 ,  G01N2333/52 ,  G01N2333/71 ,  G01N2500/00

摘要： Diagnostics and remedies for inflammatory diseases, delayed hypersensitivity, malignant tumor and arteriosclerosis which contain, as the active ingredient, a substance binding to human VEGF receptor Flt-1 or a substance inhibiting signal transduction mediated by human VEGF receptor Flt-1.

公开(公告)号：EP1957643A2

公开(公告)日：2008-08-20

申请号：EP06808510.9

申请日：2006-11-13

申请人： The University Court Of The University of Edinburgh

发明人： CHAMBERS, Ian ,  DA SILVA, Jose Rebero Institute for Stem Cell Research ,  SMITH, Austin, Gerard

IPC分类号： C12N15/06

CPC分类号： C12N5/16 ,  C12N5/0696 ,  C12N2501/605 ,  C12N2501/70 ,  C12N2501/999 ,  C12N2506/00 ,  C12N2506/02

摘要： Methods for reprogramming and optional genetic modification of cells are provided. A pluripotent genome is obtained from a differentiated genome by fusing a pluripotent cell with a differentiated cell in the presence of Nanog or a MEK inhibitor. A cell is genetically modified by providing first and second cells, each containing chromosomes, fusing the first cell and the second cell, and culturing the fused cell so as to obtain a diploid cell containing at least one chromosome from the first cell and at least one chromosome form the second cell. A method of cell fusion comprises fusing a first cell and a second cell in the presence of Nanog or a MEK inhibitor. Cells obtained thereby and their uses are also described.

公开(公告)号：EP1575998A4

公开(公告)日：2007-07-25

申请号：EP03814324

申请日：2003-12-18

申请人： SQUIBB BRISTOL MYERS CO

发明人： SCHILLING BERNHARD M ,  MATLOCK LINDA ,  ZEGARELLI STEPHEN G ,  BURNETT WILLIAM V JR ,  JOOSTEN CHRISTOPH E ,  BASCH JONATHAN D ,  SAKHAMURI SIVAKESAVA ,  LEE STEVEN S

IPC分类号： C07K14/705 ,  C12N5/00 ,  C12N5/02 ,  C12P21/00 ,  C12N15/06 ,  A61K38/00 ,  C12N15/09 ,  C12N15/85 ,  C12P5/00

CPC分类号： C12P21/005 ,  C07K14/70521 ,  C12N5/0018 ,  C12N2500/34 ,  C12N2500/74 ,  C12N2501/33 ,  C12N2501/90 ,  C12N2501/905 ,  C12N2501/91 ,  C12N2510/02

摘要： The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, preferably, but not limited to, fed-batch cell cultures. In one aspect, the methods comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. Throughout their duration, the culturing processes of the invention involving two or more downward shifts in temperature sustain a high viability of the cultured cells, and can yield an increased end titer of protein product, and a high quality of protein product, as determined, e.g., by sialic acid content of the produced protein. In another aspect, the methods comprise the delayed addition of polyanionic compound during the culturing period. The delayed addition of polyanionic compound sustains a high viability of the cultured cells, and can extend the growth phase, delay the onset of the death phase, and arrest the death phase.

公开(公告)号：EP1506235B1

公开(公告)日：2007-05-30

申请号：EP03725333.3

申请日：2003-04-17

申请人： EUROPEAN MOLECULAR BIOLOGY LABORATORY

发明人： SAWYER, Alan, Michael European Molecular Biology ,  DE MASI, Federico European Molecular Biology

IPC分类号： C07K16/00 ,  C12N5/16 ,  C12N15/06

CPC分类号： C07K16/00

摘要： The present invention relates to methods for producing monoclonal antibodies. In particular, the invention relates to high throughput methods for producing and screening monoclonal antibodies more rapidly than conventional methods.

公开(公告)号：EP1780273A1

公开(公告)日：2007-05-02

申请号：EP07002896.4

申请日：2002-06-21

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Aburatani, Hiroyuki ,  Nakamura, Tetsuo ,  Tsuchiya, Masayuki

IPC分类号： C12N15/06 ,  C07K16/18 ,  A61K39/00

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/3076 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734

摘要： An antiglypican 3 antibody for use in the treatment of the human or animal body by therapy is provided.

摘要翻译： 提供了通过治疗用于治疗人或动物体的抗胰蛋白聚糖3抗体。