-
公开(公告)号：EP4424379A3
公开(公告)日：2024-10-30
申请号：EP24184424.0
申请日：2020-03-11
申请人： CONVERGENE LLC , The United States of America, as represented by The Secretary, Department of Health and Human Services
发明人： YOSHIOKA, Makoto , YANG, Shyh-Ming , STROVEL, Jeffrey , MALONEY, David , JADHAV, Ajit , URBAN, Daniel Jason
IPC分类号： C07D413/14 , C07D471/04 , A61K31/517 , A61P11/00 , A61P35/00
摘要： The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.
-
公开(公告)号：EP4406605A3
公开(公告)日：2024-10-30
申请号：EP24166770.8
申请日：2021-04-07
申请人： Hista RX LLC
发明人： HOGAN II, Reed B.
IPC分类号： A61K31/135 , A61K31/341 , A61K31/4164 , A61K31/426 , A61K31/495 , A61K45/06 , A61P11/00 , A61P31/14 , A61P31/16
摘要： A method of treating or preventing acute respiratory distress syndrome associated with viral infections in a patient that includes administering an H1 receptor antagonist and an H2 receptor antagonist to the patient.
-
公开(公告)号：EP4446312A1
公开(公告)日：2024-10-16
申请号：EP23737317.0
申请日：2023-01-06
发明人： KIMBARA Atsushi , HARADA Takeo , KOMIYAMA Susumu , OKUYAMA Mizuki , OHTAKE Yoshihito , MURATA Yoshihisa , SAITO Rie
IPC分类号： C07D217/06 , A61K31/472 , A61K31/4725 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/5415 , A61K31/551 , A61P11/00 , A61P13/12 , A61P25/00 , A61P43/00 , C07D237/32 , C07D265/14 , C07D279/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/10 , C07D413/12 , C07D417/10
摘要： Provided is a low-molecular compound or a salt thereof, or a solvate thereof which has the ability to activate Nrf2.
The present invention provides a compound represented by the formula (1) or a salt thereof, or a solvate thereof, wherein X a1 is CR a1 or N, X a3 is CR a3 or N, R a1 , R a2 and R a3 are each independently selected from the group consisting of hydrogen, halogen and C 1 -C 6 alkoxy, X b1 , X b2 and X b3 are each independently selected from the group consisting of CH 2 , O, NH, S and C=O, Y is C 6 -C lO aryl optionally having a substituent or 5- to 10-membered heteroaryl optionally having a substituent, and Z is C 6 -C lO aryl optionally having a substituent, 5- to 10-membered heteroaryl optionally having a substituent or C 1 -C 6 alkyl optionally having a substituent.-
14.发明公开
公开(公告)号：EP4442263A1
公开(公告)日：2024-10-09
申请号：EP22901526.8
申请日：2022-09-21
申请人： Medipost Co., Ltd.
发明人： YANG, Yun Sun , OH, Won Il , CHOI, Soo Jin , JIN, Hye Jin , BAE, Yun Kyung , LEE, Hyang Ju
摘要： Provided are a composition for use in preventing or treating lung disease comprising mesenchymal stem cells overexpressing CD47 as an active ingredient. The mesenchymal stem cells overexpressing CD47 show a high survival rate and ability to migrate to lung tissues in vivo even when they are not autologous, reduce the inflammatory response in lung tissues, and exhibit the effect of suppressing fibrosis, and therefore can be widely used for the prevention or treatment of various lung diseases associated with lung inflammation or fibrosis.
-
公开(公告)号：EP4236931B1
公开(公告)日：2024-10-09
申请号：EP21811683.8
申请日：2021-10-29
IPC分类号： A61K31/15 , A61K31/198 , A61K31/352 , A61K31/4045 , A61K38/21 , A61P11/00
CPC分类号： A61K31/352 , A61K31/15 , A61K38/212 , A61K38/215 , A61K38/217 , A61K31/198 , A61K31/4045 , A61P11/00
-
16.发明公开
公开(公告)号：EP4434529A1
公开(公告)日：2024-09-25
申请号：EP23382262.6
申请日：2023-03-21
申请人： Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal , Fundación Para La Investigación Biomédica Del Hospital Infantil Universitario Niño Jesús
发明人： DEL CERRO MARÍN, María Jesús , ÁLVAREZ FUENTE, María , RAMIREZ ORELLANA, Manuel , MELEN FRAJLICH, Gustavo Javier
摘要： The present invention pertains to the medical field. In particular, to a pharmaceutical composition comprising an effective amount of isolated human mesenchymal stem cells (MSCs) in an acceptable pharmaceutical liquid medium for injection, for use in a method of preventing or treating a human subject having or at risk of developing bronchopulmonary dysplasia.
-
17.发明公开
公开(公告)号：EP4400119A3
公开(公告)日：2024-09-25
申请号：EP24172897.1
申请日：2019-04-09
发明人： Denk, Oliver , Börner, Gerhard , Iacono, Aldo
CPC分类号： A61K9/127 , A61K9/19 , A61K38/13 , A61K9/0078 , A61K47/24 , A61K47/26 , A61K47/183 , A61K47/02
摘要： The present invention relates to a composition comprising cyclosporine A (CsA) for use in the prevention of bronchiolitis obliterans syndrome (BOS) in a double lung transplanted patient, or for the treatment of BOS or for the prevention or delay of the progression of BOS in a double lung transplanted patient being diagnosed with BaS,
wherein the composition is administered to said patient by inhalation of said composition in aerosolized form comprising a therapeutically effective dose of cyclosporine A.-
公开(公告)号：EP4199922B1
公开(公告)日：2024-09-25
申请号：EP21765908.5
申请日：2021-08-20
IPC分类号： A61K31/426 , A61P11/00 , A61P11/06
CPC分类号： A61K31/426 , A61P11/00 , A61P11/06
-
公开(公告)号：EP4429700A1
公开(公告)日：2024-09-18
申请号：EP22805925.9
申请日：2022-11-08
IPC分类号： A61K45/06 , A61K31/536 , A61K31/137 , A61K31/5513 , A61K31/713 , A61K48/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P35/00 , G01N33/68 , G01N33/50 , C12Q3/00 , C12Q1/00 , C40B30/00
CPC分类号： A61K45/06 , A61K48/005 , A61P31/00 , A61P35/00 , A61P31/14 , A61P29/00 , A61P25/28 , A61P9/00 , A61P13/12 , A61P31/04 , A61P31/10 , G01N33/6893 , A61P11/00 , C12N15/907 , G01N2800/709520130101 , G01N33/5044 , A61K31/7088
-
20.发明公开
公开(公告)号：EP4429649A1
公开(公告)日：2024-09-18
申请号：EP22830640.3
申请日：2022-11-10
IPC分类号： A61K31/138 , A61K31/433 , A61K31/5375 , A61K45/06 , A61P11/00
CPC分类号： A61K31/433 , A61K31/138 , A61K31/5375 , A61K45/06 , A61P11/00 , A61K2300/0020130101
-
-
-
-
-
-
-
-
-
搜索结果
9266 条记录 (耗时 0.021 秒)
