VERFAHREN ZUR HERSTELLUNG VON DRONABINOL AUS CANNABIDIOL UNTER VERWENDUNG EINES MOLEKULARSIEBS
    14.
    发明公开
    VERFAHREN ZUR HERSTELLUNG VON DRONABINOL AUS CANNABIDIOL UNTER VERWENDUNG EINES MOLEKULARSIEBS 有权
    用于生产屈大麻酚大麻二酚断用分子筛

    公开(公告)号:EP1896389A1

    公开(公告)日:2008-03-12

    申请号:EP06754056.7

    申请日:2006-06-01

    申请人: Bionorica AG

    CPC分类号: C07D311/80

    摘要: The present invention relates to a method for the production of dronabinol ((6aR-trans)-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-6H- dibenzo[b,d]pyran-1-ol, Δ9-tetrahydrocannabinol (Δ9-THC)) from cannabidiol (CBD) by the cyclisation of cannabidiol (CBD) (2-[1 R-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzoldiol) to Δ9-THC. The method according to the invention is characterised in that cannabidiol (CBD) is provided in an organic solvent and is cyclised to Δ9-THC by heating, in the presence of a molecular sieve. It was ascertained that, in the method according to the invention, in addition to the previously described drying properties, the molecular sieve also has good catalytic properties, which play an important part in the above reaction. As a rule, cyclisation carried out in the presence of a Lewis acid catalyst alone is markedly slower and yields less Δ9-THC than cyclisation carried out in the presence of a molecular sieve.

    VERFAHREN ZUR HERSTELLUNG VON POLYISOBUTENYLPHENOLEN

    公开(公告)号:EP1320556A2

    公开(公告)日:2003-06-25

    申请号:EP01982370.7

    申请日:2001-09-27

    IPC分类号: C08F8/02 C07C37/14

    CPC分类号: C08F8/02 C08F10/10

    摘要: The invention relates to a method for the production of polyisobutenylphenoles by alkylation of an aromatic hydroxy compound with substantially singly ethylenically unsaturated and substantially homopolymer polyisobutenes in the presence of a Lewis-acid alkylation catalyst, characterised in that, ether is used as an additional co-catalyst, whereby in the case of BF3 the ether has a molecular weight as a Lewis-acid of at least 102 g/mol.

    摘要翻译: 本发明涉及通过在路易斯酸烷基化催化剂存在下用基本上单烯属不饱和和基本上均聚的聚异丁烯烷基化芳族羟基化合物来制备聚异丁烯基苯酚的方法,其特征在于,使用醚作为另外的共 - 由此在BF 3的情况下,醚具有至少102g / mol的路易斯酸分子量。