公开(公告)号：EP1578903A4

公开(公告)日：2007-05-23

申请号：EP02762148

申请日：2002-04-17

申请人： DYAX CORP

发明人： LADNER ROBERT C ,  COHEN EDWARD H ,  NASTRI HORACIO G ,  ROOKEY KRISTIN L ,  HOET RENE ,  HOOGENBOOM HENRICUS R J M

IPC分类号： C07K1/04 ,  C07K16/00 ,  C07K17/00 ,  C12N1/00 ,  C12N15/10 ,  C12N15/11 ,  C12N15/13 ,  C12N15/66 ,  C12Q1/44 ,  C12Q1/68 ,  C40B40/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12P21/04 ,  C12P21/06 ,  C12Q1/70 ,  C12Q3/00 ,  G01N33/53

CPC分类号： C07K16/005 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/622 ,  C12N15/10 ,  C12N15/1037 ,  C12N15/1093 ,  C12N15/66 ,  C40B40/02 ,  C40B40/08

公开(公告)号：EP1663279A2

公开(公告)日：2006-06-07

申请号：EP04782687.0

申请日：2004-08-30

申请人： Dyax Corp. ,  Nektar Therapeutics

发明人： LADNER, Robert, C. ,  SATO, Aaron, K. ,  AMARAL, Michelle ,  BOSSARD, Mary, J. ,  ROBERTS, Michael, J. ,  ZHANG, Yan ,  LEY, Arthur, C.

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N9/00 ,  C12N9/66

CPC分类号： C07K14/8114 ,  A61K38/00 ,  A61K47/60 ,  A61K49/0002

摘要： DX-890 inhibits elastase. DX-890 can be attached a single polyethylene glycol moiety. The polyethylene glycol is at least 18 kDa in molecular weight and is attached to the polypeptide by a single covalent bond to the N-terminus of the polypeptide.

公开(公告)号：EP1485075A4

公开(公告)日：2006-04-26

申请号：EP03742843

申请日：2003-02-20

申请人： DYAX CORP ,  TECHNION RES & DEV FOUNDATION

发明人： HOOGENBOOM HENRICUS RENERUS JA ,  REITER YORAM

IPC分类号： A01K67/027 ,  A61K39/395 ,  A61K49/00 ,  A61K51/00 ,  A61P35/00 ,  A61P37/04 ,  C07K14/47 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  A61K31/00 ,  A01K67/00 ,  A61K39/00 ,  C07K16/00 ,  C07K17/00 ,  C12P21/00

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/2833 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55

公开(公告)号：EP1497318A4

公开(公告)日：2006-03-01

申请号：EP02723923

申请日：2002-04-18

申请人： DYAX CORP

发明人： RONDON ISAAC JESUS ,  WU QI-LONG ,  LEY ARTHUR C ,  STOCHL MARK ,  RANSOHOFF THOMAS C ,  POTTER M DANIEL

IPC分类号： G01N33/50 ,  C07K7/08 ,  C07K14/735 ,  C07K16/00 ,  C12N7/00 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K14/00 ,  A61K38/00

CPC分类号： C07K14/70535

公开(公告)号：EP1603935A2

公开(公告)日：2005-12-14

申请号：EP04716901.6

申请日：2004-03-03

申请人： Dyax Corp. ,  BRACCO International B.V.

发明人： SATO, Aaron, K. ,  DRANSFIELD, Daniel, T. ,  LADNER, Robert, C. ,  THOMAS, Regi ,  NANJAPPAN, Palaniappa

IPC分类号： C07K1/00

CPC分类号： C07K7/08 ,  A61K47/543 ,  A61K47/60 ,  A61K47/665 ,  A61K49/0043 ,  A61K49/0056 ,  A61K51/08 ,  B82Y5/00 ,  C07K14/00 ,  C07K14/4753

摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.

公开(公告)号：EP1536818A2

公开(公告)日：2005-06-08

申请号：EP03745559.9

申请日：2003-03-25

申请人： Dyax Corp.

发明人： WESCOTT, Charles, R. ,  WESCOTT, Charles, R. ,  SATO, Aaron, K.

IPC分类号： A61K38/12

CPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  G01N33/86 ,  G01N2333/75

摘要： Compositions comprising non-naturally occurring fibrinogen binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating fibrinogen molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to fibrinogen. Preferred binding peptides having a high affinity for fibrinogen are particularly disclosed.

公开(公告)号：EP1126864A4

公开(公告)日：2004-11-03

申请号：EP99961607

申请日：1999-11-04

申请人： DYAX CORP

发明人： WHELIHAN E FAYELLE

IPC分类号： A61K39/00 ,  A61K39/23 ,  A61K39/395 ,  C07K16/00 ,  C07K16/08 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/569 ,  A61K38/00 ,  A61K38/04 ,  A61K39/12 ,  C12N5/06 ,  C12N7/00

CPC分类号： G01N33/56983 ,  A61K39/00 ,  G01N2333/015

公开(公告)号：EP1438400A1

公开(公告)日：2004-07-21

申请号：EP02766425.9

申请日：2002-09-30

申请人： Dyax Corp.

发明人： HUFTON, Simon, E. ,  HOOGENBOOM, Hendricus, R., J., M.

IPC分类号： C12N15/00

CPC分类号： C12N15/1037 ,  C12N15/85 ,  C12N2795/00043 ,  C12N2800/108 ,  C12N2830/002 ,  C12N2840/20 ,  C40B40/02 ,  G01N33/554

摘要： A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets.

公开(公告)号：EP1326882A2

公开(公告)日：2003-07-16

申请号：EP01946519.4

申请日：2001-06-19

申请人： Dyax Corp.

发明人： LEY, Arthur, Charles ,  LUNEAU, Christopher, Jon ,  LADNER, Robert, Charles

IPC分类号： C07K7/06 ,  C12N15/11 ,  C12N15/10 ,  C12N15/62

CPC分类号： C07K7/06

摘要： Novel enterokinase cleavage sequences are provided. Also disclosed are methods for the rapid isolation of a protein of interest present in a fusion protein construct including a novel enterokinase cleavage sequence of the present invention and a ligand recognition sequence for capturing the fusion construct on a solid substrate. Preferred embodiments of the present invention show rates of cleavage up to thirty times that of the known enterokinase cleavage substrate (Asp)4-Lys-Ile.

公开(公告)号：EP0573603B1

公开(公告)日：2003-06-25

申请号：EP92908481.2

申请日：1992-02-28

申请人： Dyax Corp.

发明人： LEY, Arthur, Charles ,  LADNER, Robert, Charles ,  GUTERMAN, Sonia, Kosow ,  ROBERTS, Bruce, Lindsay ,  MARKLAND, William ,  KENT, Rachel, Baribault

IPC分类号： C07K14/47

CPC分类号： C40B40/02 ,  A61K38/00 ,  C07K1/047 ,  C07K14/43522 ,  C07K14/8114 ,  C07K14/8117 ,  C12N7/00 ,  C12N15/1037 ,  C12N2795/18122

摘要： Novel small proteins which bind elastase or cathepsin G have been identified. These are useful as inhibitors of excessive elastase or cathepsin G activity in patients.