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49 条记录 (耗时 0.035 秒)

    PARALLEL PATCH CLAMP SYSTEM
    22.
    发明公开
    PARALLEL PATCH CLAMP SYSTEM 有权
    并行膜片钳系统

    公开(公告)号：EP1802752A2

    公开(公告)日：2007-07-04

    申请号：EP05795434.9

    申请日：2005-09-09

    申请人： MOLECULAR DEVICES CORPORATION

    发明人： FINKEL, Alan S., Molecular Devices Corporation

    IPC分类号： C12N13/00 ,  C12M1/34

    CPC分类号： G01N33/48728 ,  G01N33/6872 ,  G01N2500/00

    摘要： A system for high-throughput analysis of membranous samples having ion channels including at least one membranous sample, a multi-compartment structure including an extracellular chamber, an opposing intracellular chamber and a partition separating the extracellular and intracellular chambers, the partition having a plurality of apertures fluidly and electrically coupling the extracellular and intracellular chambers, wherein at least one of the apertures is sealed by the at least one membranous sample, and another of the apertures is unsealed, a electric source configured to apply a current between the extracellular and intracellular chambers, wherein a portion of the current travels through the unsealed aperture, and a current sensor configured to measure the current between the extracellular and intracellular chambers. A method of using the system is also disclosed.

    Integrated fluid delivery and analysis system
    23.
    发明公开
    Integrated fluid delivery and analysis system 有权
    集成的流体输送和分析系统

    公开(公告)号：EP1231472A1

    公开(公告)日：2002-08-14

    申请号：EP02250913.7

    申请日：2002-02-11

    申请人： Molecular Devices Corporation

    发明人： Giebeler, Robert H. ,  Humphries, Gillian M. ,  Ogle, David G. ,  Hafeman, Dean G. ,  Kaye, Roger A. ,  Modlin, Douglas N. ,  McNerney, Steven A.

    IPC分类号： G01N35/00

    CPC分类号： G01N21/253 ,  G01N35/028 ,  G01N35/1065 ,  G01N35/109 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00455 ,  G01N2035/0498 ,  G01N2035/103

    摘要： An integrated fluid delivery and analysis system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others. The system comprises a detection device (1201) configured to detect light from a sample at an examination site, a sample delivery axis extending substantially vertically from the examination site (1604); and at least one material exchange station (1600) along the sample delivery axis above the examination site. Typically, there are: a fluidics head assembly including a dispensing device; a drive mechanism connected to the head assembly for moving the head assembly along a substantially vertical sample delivery axis; and at least two material exchange stations (1600,1602) located along the sample delivery axis, the head assembly being moveable to each material exchange station (1600,1602) to pick up or deposit materials used to conduct an assay.

    摘要翻译： 用于制备和/或分析样品的集成流体输送和分析系统及其部件。 这些组件可以包括运送模块，流控模块和分析模块等。 该系统包括检测装置（1201），检测装置（1201）被配置为检测来自检查部位处的样本的光线，样本递送轴线从检查部位（1604）基本竖直地延伸; 和沿检查部位上方的样本输送轴线的至少一个材料交换站（1600）。 典型地，存在：包括分配装置的流控头组件; 驱动机构，连接到所述头部组件，用于沿着基本竖直的样本传送轴线移动所述头部组件; 和至少两个沿着样本输送轴线定位的材料交换站（1600,1602），头部组件可移动到每个材料交换站（1600,1602）以拾取或沉积用于进行测定的材料。

    Photoresponsive electrode for determination of redox potential
    27.
    发明公开
    Photoresponsive electrode for determination of redox potential 失效
    Photoempfindlic Elektrode zur Bestimmour des Redox-Potentiales。

    公开(公告)号：EP0300651A2

    公开(公告)日：1989-01-25

    申请号：EP88306248.1

    申请日：1988-07-08

    申请人： Molecular Devices Corporation

    发明人： Hafeman, Dean

    IPC分类号： G01N27/00

    CPC分类号： G01N27/305

    摘要： Devices and methods are provided for determining the presence and amount of an analyte by measuring a redox potential-modulated photoinducing signal from a photoresponsive element and are provided for determining the presence and amount of an analyte by measuring a redox potential, pH or ion modulated photo­induced signal from a photoresponsive element (150), where one signal is a constant system (122) and the other signal(s) (120) is a variable system. The constant system signal is used to standardize the variable system signal e.g. via operational amplifier (110) and reference electrode (170). Various protocols may be employed where an analyte may be directly or indirectly coupled to a redox couple, a pH or ion system for detection. A photoresponsive element may have a medium-contacting surface which is partially covered with an electronically conducting layer (153) and partially covered with a protective insulative layer (152).

    摘要翻译： 提供了用于通过测量来自光响应元件的氧化还原电位调节的光诱导信号来确定分析物的存在和量的装置和方法，用于通过测量氧化还原电位，pH或离子调制光诱导来测定分析物的存在和量 来自光响应元件（150）的信号，其中一个信号是恒定系统（122），另一个信号（120）是可变系统。 恒定系统信号用于标准化可变系统信号，例如。 经由运算放大器（110）和参考电极（170）。 可以使用各种方案，其中分析物可以直接或间接偶联到氧化还原对，用于检测的pH或离子系统。 光响应元件可以具有中间接触表面，其被部分地覆盖有电子导电层（153）并部分地被保护绝缘层（152）覆盖。

    Electrochemical analysis method
    28.
    发明公开
    Electrochemical analysis method 失效
    Elektrochemische Analysenmethode。

    公开(公告)号：EP0255223A2

    公开(公告)日：1988-02-03

    申请号：EP87305456.3

    申请日：1987-06-19

    申请人： Molecular Devices Corporation

    发明人： Parce, John W. ,  Zuk, Robert F.

    IPC分类号： G01N27/26 ,  G01N27/28 ,  G01N27/07 ,  G01N27/00 ,  G01N33/53

    CPC分类号： G01N27/3271 ,  G01N27/327 ,  Y10S435/817 ,  Y10S436/806

    摘要： Methods and apparatuses are described for determining the presence of an analyte in a sample suspected of containing the analyte. The method comprises contacting a concentrate of a determinable element capable of being detected by means of a semiconductive electrode with the electrode in the presence of a relatively large volume of an assay medium. The determinable element is present in the concentrate in the amount related to the amount of analyte present in the sample. The volume of the medium in diffusive communication with the concentrate is then reduced and the determinable element is detected by means of the effect that the determinable element has on the semiconductive electrode.

    摘要翻译： 描述了用于确定疑似含有分析物的样品中分析物的存在的方法和装置。 该方法包括在相对较大体积的测定介质的存在下使能够通过半导体电极检测的可测定元件的浓缩物与电极接触。 浓缩物中可测定的元素以与样品中存在的分析物的量相关的量存在。 然后减少与浓缩物扩散连通的介质的体积，并且通过可确定元件在半导体电极上具有的效果来检测可确定元件。