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公开(公告)号：EP3135753B1
公开(公告)日：2019-12-25
申请号：EP15770338.0
申请日：2015-03-23
发明人： IKENAGA, Takeshi , NODA, Tsuneyuki , NOGUCHI, Hiroki , UEDA, Atsushi , KOUDA, Noriyuki , TAJIRI, Yoshito
IPC分类号： C12N1/20 , A23L33/135 , A61K35/747 , A61P3/00 , A61P3/06 , C12R1/225
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22.发明公开
公开(公告)号：EP3563689A1
公开(公告)日：2019-11-06
申请号：EP19175944.8
申请日：2009-09-18
发明人： Isono, Yoshikazu , Mori, Hisako , Ueno, Tomomi , Endo, Rieko , Kumemura, Megumi , Abiru, Yasuhiro , Uchiyama, Shigeto
IPC分类号： A23C9/123 , A23C9/13 , A23C11/10 , A23L11/00 , A23L29/00 , A23L33/135 , C07D311/60
摘要： An object of the present invention is to provide a fermented product containing equol-producing microorganisms in the state of living cells by which equol production ability is maintained.
When producing a fermented material by using an equol-producing microorganism, with soybean powder or soybean milk as raw materials, (1) preparing a mother starter by fermentation under anaerobic conditions by using an equol-producing microorganism in the presence of a daidzein species at pH 5.0 or higher, (2) preparing a bulk starter by fermentation under anaerobic conditions by using said mother starter in the presence of a daidzein species at pH 5.0 or higher, and (3) preparing a fermented material by fermentation by using said bulk starter in a medium containing soybean powder or soybean milk, enables production of a fermented material containing microorganisms in the state of living cells in which the equol production ability is maintained.-
公开(公告)号：EP3095439B1
公开(公告)日：2019-07-17
申请号：EP14878522.3
申请日：2014-08-04
发明人： KAKO, Junko , OGIHARA, Miyoko , SUMA, Momoko
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公开(公告)号：EP3186240B1
公开(公告)日：2019-06-12
申请号：EP15763096.3
申请日：2015-08-28
发明人： SHIMIZU, Hiroshi , KAWANO, Yoshikazu , ISHIKAWA, Shunpei , UEMATSU, Yukitaka , SHINOHARA, Toshio , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , TAKEMURA, Isao , KANESHIGE, Atsunori , NAKAI, Yuya , HARIGUCHI, Norimitsu , HAYASHI, Yohei , MATSUMOTO, Makoto
IPC分类号： C07D401/14 , C07D215/227 , C07D401/06 , A61K31/4709 , A61P31/06
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25.发明公开
公开(公告)号：EP3489364A1
公开(公告)日：2019-05-29
申请号：EP17830990.2
申请日：2017-07-18
摘要： Provided are a method for assisting in determining the hematological stage of childhood acute lymphoblastic leukemia (child ALL), and an in-vitro diagnostic pharmaceutical product usable in the method. The method for assisting in determining the hematological stage of child ALL comprises the steps of (1) obtaining the mRNA level of Wilms' tumor-1 gene (WT1) in at least one of the biological samples of peripheral blood and bone marrow fluid from a test subject; (2) obtaining the GAPDH mRNA level in the biological sample; and (3) calculating an index value necessary for assisting in the determination based on the ratio of the WT1 mRNA level obtained in step (1) to the GAPDH mRNA level obtained in step (2).
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公开(公告)号：EP3466427A1
公开(公告)日：2019-04-10
申请号：EP17802907.0
申请日：2017-05-26
发明人： GOTO, Kazunori , NAKAHIGASHI, Jun , SATO, Atsuya , HIRAYAMA, Yosuke , HORIKOSHI, Moeri , KOUDA, Noriyuki , INOUE, Syoichiro , SATO, Ikutaro , KATO, Manami
IPC分类号： A61K31/4985 , A61P25/00 , A61P25/18 , A61P25/20 , A61P43/00
摘要： The present invention provides a heat shock protein expression-inducing agent, more specifically, a heat shock protein expression-inducing agent comprising a compound represented by formula (I):
wherein R is a lower alkyl, phenyl, or hydroxyphenyl, or a salt thereof.-
公开(公告)号：EP3421454A1
公开(公告)日：2019-01-02
申请号：EP17756680.9
申请日：2017-02-27
发明人： KAWANO, Yoshikazu , SHIMIZU, Hiroshi , ISHIKAWA, Shunpei , TAKEMURA, Isao , HARIGUCHI, Norimitsu , MATSUBA, Miki , MATSUMOTO, Makoto
IPC分类号： C07D211/44 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/517 , A61K31/536 , A61K31/5415 , A61K31/55 , A61K31/553 , A61K31/554 , A61P31/06 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]:
(in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.-
公开(公告)号：EP3063164B1
公开(公告)日：2018-12-05
申请号：EP14802970.5
申请日：2014-10-29
IPC分类号： C07H19/06
摘要： The present invention relates to methods and intermediates for synthesizing 2′-deoxy-2′,2′-difluorotetrahydrouridine compounds.
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公开(公告)号：EP3318557A2
公开(公告)日：2018-05-09
申请号：EP17202139.6
申请日：2012-08-30
发明人： ABUDUSAIMI, Mamuti , YE, Fangguo , SUN, Jiangqin , MIYAMOTO, Hisashi , CHENG, Jay-Fei , OKA, Daisuke
IPC分类号： C07D215/56 , C07D471/04 , A61K31/47 , A61K31/435
CPC分类号： C07D215/56 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D519/00
摘要： The present invention provides a compound represented by the formula (I)
wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R 1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R 2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R 3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.摘要翻译： 本发明提供由式（I）表示的化合物，其中X是氢原子或氟原子; R是氢原子或烷基; R1为（1）任选被1至3个卤素原子取代的环丙基或（2）任选被1至3个卤素原子取代的苯基; R2为烷基，烷氧基，卤代烷氧基，卤素原子，氰基等; 和R3是7-氧代-7,8-二氢-1,8-二氮杂萘基，3-吡啶基等，或其盐。 本发明化合物对艰难梭菌具有优良的抗微生物活性，并且可用于预防或治疗肠道感染如艰难梭菌相关性腹泻。
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30.发明公开METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF 审中-公开生产1-（4-羟基苯基）-4-（4-三氟甲氧基苯氧基）哌啶或其盐的方法
公开(公告)号：EP3275862A1
公开(公告)日：2018-01-31
申请号：EP16772618.1
申请日：2016-03-25
发明人： MIYAKE, Masahiro , ASAHINA, Aya , OKADA, Takahiro
IPC分类号： C07D211/46
摘要： The present invention provides a method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof, the method including the step of heating hydroquinone and 4-(4-trifluoromethoxyphenoxy)piperidine. This method can produce 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or a salt thereof in an industrially advantageous manner.
摘要翻译： 本发明提供制备1-（4-羟基苯基）-4-（4-三氟甲氧基苯氧基）哌啶或其盐的方法，该方法包括加热氢醌和4-（4-三氟甲氧基苯氧基）哌啶的步骤。 该方法能够以工业上有利的方式制备1-（4-羟基苯基）-4-（4-三氟甲氧基苯氧基）哌啶或其盐。
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