公开(公告)号：EP0745690B1

公开(公告)日：2008-10-22

申请号：EP96303544.9

申请日：1996-05-10

申请人： PHRI Properties, Inc.

发明人： Tyagi, Sanjay ,  Kramer, Fred R ,  Lizardi, Paul M

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6816 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6841 ,  C12Q2565/101 ,  C12Q2565/1015 ,  C12Q2561/113 ,  C12Q2525/301 ,  C12Q2521/301 ,  C12Q2537/143 ,  C12Q2531/113

公开(公告)号：EP0906577B1

公开(公告)日：2008-09-03

申请号：EP97932208.8

申请日：1997-06-18

申请人： ELAN PHARMACEUTICALS, INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： CITRON, Martin ,  SELKOE, Dennis, J. ,  SEUBERT, Peter, A. ,  SCHENK, Dale

IPC分类号： G01N33/68 ,  G01N33/50

CPC分类号： C07K14/4711 ,  A61K38/00 ,  C07K16/18 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2500/00 ,  G01N2500/10 ,  G01N2800/2821

摘要： This invention provides methods of screening compounds for their ability to alter the production of Aβ (x≥41) alone or in combination with Aβ (x≤40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ (x≤40) and Aβ (x≥41) produced by the cells, and comparing these amounts to that produced by the cells without administration of the compounds.

公开(公告)号：EP1916303A1

公开(公告)日：2008-04-30

申请号：EP07021977.9

申请日：2001-11-30

申请人： MEDAREX, INC. ,  KIRIN BEER KABUSHIKI KAISHA

发明人： Tomizuka, Kazuma ,  Ishida, Isao ,  Lonberg, Nils ,  Halk, Ed

IPC分类号： C12N15/12 ,  C12N15/85 ,  C12N5/06 ,  C12N5/20 ,  C07K16/00 ,  A01K67/027

CPC分类号： A01K67/0278 ,  A01K67/02 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/072 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/70535 ,  C07K16/00 ,  C07K16/18 ,  C07K16/243 ,  C07K16/2812 ,  C07K16/2818 ,  C07K16/2863 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/92 ,  C12N5/0635 ,  C12N5/163 ,  C12N15/8509 ,  C12N2015/8518 ,  C12P21/005 ,  C12Q1/6881 ,  C12Q2600/158

摘要： The present invention provides novel transgenic nonhuman mammals capable of producing human sequence anti-bodies, as well as methods for producing and using these antibodies.

摘要翻译： 本发明提供了能够产生人序列抗体的新型转基因非人类哺乳动物，以及生产和使用这些抗体的方法。

公开(公告)号：EP1045702B1

公开(公告)日：2008-03-12

申请号：EP99902103.3

申请日：1999-01-07

申请人： University of Washington ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： BLAU, Carl, Anthony ,  SPENCER, David, M.

IPC分类号： A61K48/00 ,  C12N15/85

CPC分类号： C07K14/70503 ,  A01K67/0271 ,  A61K48/00 ,  C07K14/505 ,  C07K14/715 ,  C07K2319/00 ,  C07K2319/033 ,  C07K2319/42 ,  C07K2319/715 ,  C12N15/62 ,  C12N15/85

公开(公告)号：EP1108023B1

公开(公告)日：2007-08-15

申请号：EP99945389.7

申请日：1999-08-31

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： PASTAN, Ira ,  BRINKMANN, Ulrich ,  VASMATZIS, George ,  LEE, Byungkook

IPC分类号： C12N15/12 ,  A61K38/17 ,  A61K31/70 ,  C07K16/18 ,  A61K35/14 ,  A61K39/395 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C07K14/4748 ,  A61K39/00

摘要： PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.

摘要翻译： 雄性PAGE-4是在正常和雌性生殖组织，前列腺，睾丸，输卵管，子宫和胎盘，以及在前列腺癌，睾丸癌和子宫癌中过表达优先的基因。 这种表达模式使得它用于诊断和用于前列腺，睾丸和子宫肿瘤的基于疫苗治疗的靶。 本发明提供了免疫原性组合物，包含PAGE-4蛋白或免疫原性肽物，方法生长抑制表达PAGE-4的恶性细胞，并诱导对PAGE-4表达的癌症增强的免疫应答的方法。

公开(公告)号：EP1807103A2

公开(公告)日：2007-07-18

申请号：EP05817231.3

申请日：2005-11-04

申请人： Sirion Therapeutics, Inc.

发明人： MATA, Nathan L. ,  HAN, Yun ,  WIDDER, Kenneth ,  LICHTER, Jay

IPC分类号： A61K38/00 ,  A01N31/04

CPC分类号： G01N33/6893 ,  A61K31/16 ,  A61K31/203 ,  A61K31/215 ,  A61K41/0061 ,  A61K49/0041 ,  A61K49/0052 ,  A61K49/0056 ,  G01N33/542 ,  G01N2500/02 ,  G01N2800/164 ,  Y10S514/912 ,  A61K2300/00

摘要： Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex formation. Furthermore, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-­related macular degeneration and/or dystrophies.

公开(公告)号：EP1790202A2

公开(公告)日：2007-05-30

申请号：EP05812440.5

申请日：2005-09-16

申请人： Pacific Biosciences of California, Inc.

发明人： TURNER, Stephen ,  KORLACH, Jonas

IPC分类号： H05H3/04

CPC分类号： G01N21/6452 ,  B01L3/5085 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0896 ,  B82Y20/00 ,  B82Y30/00 ,  G02B6/13 ,  Y10T436/10

摘要： The present invention relates to optical confinements, method of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.

摘要翻译： 本发明涉及光限制，制备方法和使用它们分析分子和/或监测化学反应的方法。 体现在本发明中的设备和方法对于高通量和低成本的单分子分析特别有用。

公开(公告)号：EP1280551B1

公开(公告)日：2007-01-10

申请号：EP01927532.0

申请日：2001-04-25

申请人： Sanofi Pasteur Limited

发明人： ROVINSKI, Benjamin ,  TARTAGLIA, James ,  CAO, Shi-Xian ,  PERSSON, Roy ,  KLEIN, Michel, H.

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55577 ,  C12N2710/24043 ,  C12N2740/16122 ,  C12N2740/16134

摘要： A virus neutralizing level of antibodies to a primary HIV isolate is generated in a host by a prime-boost administration of antigents. The primary antigen is a DNA molecule encoding an envelop glycoprotein of a primary isolate of HIV-1 while the boosting antigen is either a non-infectious, non-replicating HIV-like particle having the envelope glycoprotein of a primary isolate of HIV-1 or an attenuated viral vector expressing an envelope glycoprotein of a primary isolate of HIV-1.

公开(公告)号：EP1734995A1

公开(公告)日：2006-12-27

申请号：EP04781281.3

申请日：2004-08-13

申请人： Galaxy Biotech, LLC ,  Wang, Lihong

发明人： KIM, Kyung, Jin ,  SU, Yi-Chi ,  WANG, Lihong

IPC分类号： A61K39/395 ,  C07K16/22 ,  C12N5/20 ,  G01N33/53 ,  G01N33/563 ,  G01N33/574 ,  G01N33/577

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/4753

摘要： The present invention is directed toward a neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient, such as for inhibiting glioblastoma.

公开(公告)号：EP0812333B1

公开(公告)日：2006-12-06

申请号：EP96907146.3

申请日：1996-02-29

申请人： PDL BioPharma, Inc. ,  Iowa Immunotherapy Investigators

发明人： WEINER, George ,  GINGRICH, Roger ,  LINK, Brian, K. ,  TSO, J., Yun

IPC分类号： C07K16/28 ,  C07K16/16 ,  C07K16/30 ,  A61K39/395 ,  C12N5/12 ,  C12N5/16 ,  C12N5/18 ,  C07K16/46 ,  C12N15/13 ,  C12N5/20

CPC分类号： C07K16/3061 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2809 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/92 ,  C07K2319/00

摘要： The invention provides bispecific antibodies with selective cytoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also includes the monospecific components of the bispecific antibodies, humanized versions thereof, and humanized bispecific antibodies. The invention further provides therapeutic and diagnostic methods employing these antibodies.