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公开(公告)号：EP4434626A1
公开(公告)日：2024-09-25
申请号：EP22894720.6
申请日：2022-11-11
申请人： Xiamen University , Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. , Xiamen Innodx Biotech Co., Ltd
发明人： ZHANG, Dongxu , GAO, Runxin , HUANG, Shaolei , HUANG, Yulin , LIU, Guoqiang , YANG, Jiayu , ZENG, Juntian , SONG, Liuwei , GE, Shengxiang , ZHANG, Jun , XIA, Ningshao
摘要： The present disclosure relates to a microfluidic chip and a microfluidic chip detection system. The microfluidic chip including: a storage member provided with a groove therein, at least two storage chambers being disposed around the groove; a base disposed at one end of the storage member away from the groove, a reaction chamber being disposed on the base; and a valve disposed in the groove, the valve being configured to operatively communicate any one of the at least two storage chambers with the reaction chamber. The present disclosure can lead the solution in any storage chamber to the reaction chamber or lead the solution in the reaction chamber to any storage chamber by operating the valve, so that the solution transfer is realized, the structure is simple and compact, the length of the flow channels can be greatly shortened, and the detection efficiency is improved.
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22.发明公开
公开(公告)号：EP4378951A1
公开(公告)日：2024-06-05
申请号：EP22848410.1
申请日：2022-07-21
发明人： CHENG, Tong , ZHU, Rui , YANG, Hongwei , XU, Longfa , LIN, Yu , ZHOU, Zhenhong , YE, Xiangzhong , XIA, Ningshao
IPC分类号： C07K7/08 , C12N15/00 , A61K39/125 , A61K48/00
CPC分类号： C12N15/00 , C07K7/08 , A61K48/00 , A61K39/125
摘要： The present invention belongs to the field of immunobiology, and relates to an epitope polypeptide, such as a general affinity epitope polypeptide of human rhinovirus, and the use thereof. The present invention further relates to an antibody capable of binding to the epitope polypeptide and the use thereof. The present invention further relates to the use of the affinity epitope polypeptide or the antibody in the preparation of drugs or in methods for treating and/or preventing and/or diagnosing human rhinovirus and/or identifying a titer of human rhinovirus and/or identifying a titer of a neutralizing antibody of human rhinovirus. The affinity epitope polypeptide and antibody can be used in drugs or methods for treating and/or preventing and/or diagnosing human rhinovirus and/or identifying a titer of human rhinovirus and/or identifying a titer of a neutralizing antibody of human rhinovirus.
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公开(公告)号：EP4113121A1
公开(公告)日：2023-01-04
申请号：EP21760161.6
申请日：2021-01-18
发明人： LI, Tingdong , SHI, Qiaoyun , REN, Jinkai , GE, Shengxiang , HONG, Congming , ZHANG, Xiaolei , WANG, Dong , ZHOU, Guoliang , YUAN, Quan , WU, Xiaowei , WANG, Xuan , WU, Yangtao , PAN, Haifeng , QI, Yuting , JIA, Xuerong , ZHOU, Lizhi , HOU, Wangheng , QIAO, Shan , LI, Shaowei , ZHANG, Jun , XIA, Ningshao
IPC分类号： G01N33/68 , G01N33/569 , G01N33/558 , C12N15/867 , C12N15/65 , C07K14/165
摘要： Provided are a method for assaying a specific IgM antibody and a total antibody for the 2019 novel coronavirus (2019-nCOV), a method for determining whether subjects are infected with 2019-nCOV, and a virus antigen and a kit for carrying out the above-mentioned detection.
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公开(公告)号：EP2154149B1
公开(公告)日：2019-07-10
申请号：EP08757381.2
申请日：2008-05-29
发明人： LI, Shaowei , PAN, Huirong , LIU, Bo , ZHANG, Jun , MIAO, Ji , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/12 , A61K39/295 , A61P31/20 , A61P15/00 , A61P17/12
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25.发明授权Method for producing a N-terminaly truncated L1 protein of human papillomavirus (HPV) 有权Herstellung eine的方法N末端verkürztenL1蛋白质人乳头瘤病毒
公开(公告)号：EP2907821B1
公开(公告)日：2016-12-28
申请号：EP15160399.0
申请日：2008-05-29
发明人： Zhang, Yun , Wang, Jin , Yang, Chunyan , Gu, Ying , Li, Shaowei , Xia, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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公开(公告)号：EP2910566B1
公开(公告)日：2016-07-13
申请号：EP15160363.6
申请日：2008-05-29
发明人： Zhang, Yun , Wang, Jin , Yang, Chunyan , Gu, Ying , Li, Shaowei , Xia, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/295 , A61K39/12 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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27.发明授权THE POLYPEPTIDE FRAGMENTS OF HEPATITIS E VIRUS, THE VACCINE COMPOSITION COMPRISING SAID FRAGMENTS AND THE DIAGNOSTIC KITS 有权戊型肝炎病毒THAT这些片段含疫苗组合物和诊断试剂盒的多肽片段
公开(公告)号：EP1331271B1
公开(公告)日：2014-03-19
申请号：EP01994540.1
申请日：2001-09-30
发明人： XIA, Ningshao, c/o Yang Sheng Tang Company, Ltd. , ZHANG, Jun, c/o Yang Sheng Tang Company, Ltd. , LI, Shaowei, c/o Yang Sheng Tang Company, Ltd. , GE, Shengxiang, c/o Yang Sheng Tang Company, Ltd. , GU, Ying, c/o Yang Sheng Tang Company, Ltd. , HE, Zhigiang, c/o Yang Sheng Tang Company, Ltd.
IPC分类号： C12N15/51 , C12N5/10 , C07K14/005 , A61K39/29 , G01N33/576
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/29 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , A61K2039/6075 , C07K16/10 , C07K2319/00 , C12N2760/16022 , C12N2770/28122 , C12N2770/28134 , C12N2770/28171 , G01N33/576
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28.发明公开A TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 16 有权GEKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS 16
公开(公告)号：EP2154147A1
公开(公告)日：2010-02-17
申请号：EP08748431.7
申请日：2008-04-29
发明人： GU, Ying , LI, Shaowei , WEI, Minxi , XIAN, Yangling , LUO, Wenxin , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N7/02 , C07K1/18 , A61K39/12 , A61P31/20 , A61P15/02 , A61P35/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 16, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of cervical caner.
摘要翻译： 本发明涉及16型人乳头瘤病毒的截短L1蛋白，由蛋白质构成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及该疫苗在预防宫颈癌中的用途。
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公开(公告)号：EP1461357B1
公开(公告)日：2009-04-29
申请号：EP00960932.2
申请日：2000-09-28
发明人： NG,Mun,Hon Dept.of Microbio. The Uni.of Hong Kong , IM,Stanley Dept.of Microbio. The Uni.of Hong Kong , ZHANG,Ji-Zhong Dep.of Microbio. The Uni. HongKong
IPC分类号： C07K14/005 , C12N15/51 , C12N15/63
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C07K2319/00 , C12N2770/28122 , G01N33/5767 , Y10S435/975
摘要： A highly immunoreactive viral peptide, pE2, is disclosed which is derived form the carboxy-terminal end region of ORF2 region of the hepatitis E virus (HEV) genome. A unique feature of the novel pE2 peptide is that it possesses conformational antigenic determinants which are only exposed when monomers of the peptide associate with one another through non-covalent interactions to naturally form homodimers. The novel pE2 peptide is proven to be highly reactive with sera from patients having current or past infection with HEV which suggests that the homodimer may mimic certain structural features of the HEV capsid protein. Furthermore, the antigenic activity of the pE2 peptide is strictly conformational in nature and therefore, exhibits immunochemical reactivity only when the peptide exists in a dimeric form. Consequently, the antigenic activity is lost upon dissociation of the dimers, but the activity is restored when the monomers reassociate to form dimers. Moreover, diagnostic methods useful in detecting and diagnosing HEV infection, and the use of a vaccine composition effective in preventing hepatitis E virus infection in which the novel pE2 peptide is utilized are also disclosed.
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