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1.发明授权MONOCLONAL ANTIBODIES BINDING TO AVIAN INFLUENZA VIRUS SUBTYPE H5 HAEMAGGLUTININ AND USES THEREOF 有权禽流感病毒亚型HA从H5来源的结合的单克隆抗体体和应用
公开(公告)号：EP2174957B1
公开(公告)日：2016-03-16
申请号：EP08772961.2
申请日：2008-06-16
发明人： CHEN, Yixin , LUO, Wenxin , ZHANG, Jun , XIA, Ningshao , GUAN, Yi , CHEN, Honglin
IPC分类号： C07K16/18 , G01N33/53 , G01N33/569 , A61K39/395 , C07K7/06
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C12N2760/16111 , G01N33/56983 , G01N2333/11
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公开(公告)号：EP3407071A1
公开(公告)日：2018-11-28
申请号：EP17741038.8
申请日：2017-01-18
发明人： GE, Shengxiang , LIU, Yongliang , CHEN, Mengyuan , ZHANG, Jun , XIA, Ningshao
IPC分类号： G01N33/68
CPC分类号： G01N33/68
摘要： Disclosed are a method for diagnosing whether a subject is suffering from active tuberculosis, a method for determining the therapeutic effect of a therapy on active tuberculosis, a method for screening a candidate drug capable of treating active tuberculosis, and a kit comprising a specific stimulating agent and a reagent for detecting the level of IL-6, the method and kit belong to the fields of molecular biology, immunology and disease diagnosis.
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公开(公告)号：EP2154148B1
公开(公告)日：2016-06-22
申请号：EP08757380.4
申请日：2008-05-29
发明人： ZHANG, Jun , WANG, Jin , YANG, Chunyan , GU, Ying , LI, Shaowei , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/295 , A61K39/12 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
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公开(公告)号：EP2154149A1
公开(公告)日：2010-02-17
申请号：EP08757381.2
申请日：2008-05-29
发明人： LI, Shaowei , PAN, Huirong , LIU, Bo , ZHANG, Jun , MIAO, Ji , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/12 , A61K39/295 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/55566 , A61K2039/70 , C07K14/025 , C12N7/00 , C12N2700/00 , C12N2710/00 , C12N2710/20022 , C12N2710/20034 , C12P21/00 , G01N2333/025
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 6, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.
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5.发明公开A TRUNCATED L1 PROTEIN OF HUMAN PAPILLOMAVIRUS 11 有权VERKÜRZTESL1-PROTEIN DES HUMANEN PAPILLOMAVIRUS 11
公开(公告)号：EP2154148A1
公开(公告)日：2010-02-17
申请号：EP08757380.4
申请日：2008-05-29
发明人： ZHANG, Jun , WANG, Jin , YANG, Chunyan , GU, Ying , LI, Shaowei , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/295 , A61K39/12 , A61P31/20 , A61P15/00 , A61P17/12
CPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034
摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.
摘要翻译： 本发明涉及11型人乳头瘤病毒的截短的L1蛋白，由蛋白质组成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及该疫苗在预防尖锐湿疣或HPV感染中的用途。
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公开(公告)号：EP4434626A1
公开(公告)日：2024-09-25
申请号：EP22894720.6
申请日：2022-11-11
申请人： Xiamen University , Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. , Xiamen Innodx Biotech Co., Ltd
发明人： ZHANG, Dongxu , GAO, Runxin , HUANG, Shaolei , HUANG, Yulin , LIU, Guoqiang , YANG, Jiayu , ZENG, Juntian , SONG, Liuwei , GE, Shengxiang , ZHANG, Jun , XIA, Ningshao
摘要： The present disclosure relates to a microfluidic chip and a microfluidic chip detection system. The microfluidic chip including: a storage member provided with a groove therein, at least two storage chambers being disposed around the groove; a base disposed at one end of the storage member away from the groove, a reaction chamber being disposed on the base; and a valve disposed in the groove, the valve being configured to operatively communicate any one of the at least two storage chambers with the reaction chamber. The present disclosure can lead the solution in any storage chamber to the reaction chamber or lead the solution in the reaction chamber to any storage chamber by operating the valve, so that the solution transfer is realized, the structure is simple and compact, the length of the flow channels can be greatly shortened, and the detection efficiency is improved.
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公开(公告)号：EP4113121A1
公开(公告)日：2023-01-04
申请号：EP21760161.6
申请日：2021-01-18
发明人： LI, Tingdong , SHI, Qiaoyun , REN, Jinkai , GE, Shengxiang , HONG, Congming , ZHANG, Xiaolei , WANG, Dong , ZHOU, Guoliang , YUAN, Quan , WU, Xiaowei , WANG, Xuan , WU, Yangtao , PAN, Haifeng , QI, Yuting , JIA, Xuerong , ZHOU, Lizhi , HOU, Wangheng , QIAO, Shan , LI, Shaowei , ZHANG, Jun , XIA, Ningshao
IPC分类号： G01N33/68 , G01N33/569 , G01N33/558 , C12N15/867 , C12N15/65 , C07K14/165
摘要： Provided are a method for assaying a specific IgM antibody and a total antibody for the 2019 novel coronavirus (2019-nCOV), a method for determining whether subjects are infected with 2019-nCOV, and a virus antigen and a kit for carrying out the above-mentioned detection.
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公开(公告)号：EP2154149B1
公开(公告)日：2019-07-10
申请号：EP08757381.2
申请日：2008-05-29
发明人： LI, Shaowei , PAN, Huirong , LIU, Bo , ZHANG, Jun , MIAO, Ji , XIA, Ningshao
IPC分类号： C07K14/025 , C12N15/37 , C12N15/63 , C12N7/02 , C07K1/18 , A61K39/12 , A61K39/295 , A61P31/20 , A61P15/00 , A61P17/12
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公开(公告)号：EP3858867A1
公开(公告)日：2021-08-04
申请号：EP19867338.6
申请日：2019-09-26
发明人： LI, Shaowei , WANG, Daning , CHEN, Jie , GU, Ying , ZHANG, Jun , XIA, Ningshao
IPC分类号： C07K19/00 , C12N15/62 , C12N15/63 , A61K39/295 , A61P31/20
摘要： Provided are a mutated HPV51 L1 protein or a variant thereof, a coding sequence thereof, a preparation method therefor, and a virus-like particle containing same, wherein the protein or the variant and the virus-like particle thereof are capable of inducing neutralizing antibodies against at least two types of HPV (for example, HPV51 and HPV69, or HPV51, HPV69 and HPV26). Also provided is the use of the above-mentioned protein and the virus-like particle for preparing a pharmaceutical composition or a vaccine, wherein the pharmaceutical composition or the vaccine can be used to prevent infections of the at least two types of HPV and diseases caused by the infections, such as cervical cancer and condyloma acuminatum.
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公开(公告)号：EP3656854A1
公开(公告)日：2020-05-27
申请号：EP18835927.7
申请日：2018-07-18
发明人： CHENG, Tong , WANG, Wei , WAN, Junkai , FU, Wenkun , YE, Xiangzhong , ZHANG, Jun , XIA, Ningshao
摘要： Provided are an enterovirus D68 (EV-D68) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the EV-D68 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, or a pharmaceutical composition comprising the EV-D68 or a modified form thereof, or the nucleic acid molecule, and use of the EV-D68 or a modified form thereof, or the nucleic acid molecule in the manufacture of a pharmaceutical composition for treating a tumor.
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