公开(公告)号：EP0910360A1

公开(公告)日：1999-04-28

申请号：EP97928368.0

申请日：1997-06-24

申请人： NYCOMED IMAGING AS

发明人： TOWART, Robertson ,  KARLSSON, Jan, Olof, Gustav ,  JYNGE, Per

IPC分类号： A61K45 ,  A61K31 ,  A61K33 ,  A61P39

CPC分类号： A61K33/32 ,  A61K31/198 ,  A61K31/28 ,  A61K31/4415 ,  A61K31/444 ,  A61K31/675 ,  Y10S514/836 ,  A61K2300/00

摘要： The invention relates to the use of certain chelating agents and their metal chelates and to the use of certain manganese containing compounds, in particular manganese chelates, in the manufacture of a therapeutic agent for use in reducing the cardiotoxicity of an antitumor agent. Such compounds are particularly effective in reducing the side-effects of anthracycline drugs and/or paclitaxel.

公开(公告)号：EP0909392A1

公开(公告)日：1999-04-21

申请号：EP97930621.0

申请日：1997-07-03

申请人： NYCOMED IMAGING AS

发明人： LEUNBACH, Ib ,  YOUNG, Ian, The Robert Steiner MRI Unit ,  EHNHOLM, Gösta ,  HANSSON, Georg ,  PETERSSON, Stefan ,  WISTRAND, Lars-Goran ,  GOLMAN, Klaes

IPC分类号： B82B1 ,  A61B5 ,  G01N24 ,  G01R33

CPC分类号： G01R33/5601 ,  G01R33/282 ,  G01R33/62

摘要： The invention relates to a method of electron spin resonance enhanced magnetic resonance imaging comprising the steps of: (i) placing a composition comprising a contrast agent and an MR imaging agent in a first magnetic field; (ii) exciting ESR transitions in the contrast agent to generate dynamic nuclear polarisation of th e MR imaging agent; (iii) separating the contrast agent from the MR imaging agent; (iv) administering the MR imaging agent to the sample; (v) exciting NMR transitions of the MR imaging agent is a second magnetic field; and (vi) detecting MR response signals from the sample.

公开(公告)号：EP0896546A2

公开(公告)日：1999-02-17

申请号：EP97914482.0

申请日：1997-03-27

申请人： NYCOMED IMAGING AS

发明人： FAHLVIK, Anne, Kjersti

IPC分类号： A61K49

CPC分类号： A61K49/186 ,  A61K49/1863

摘要： The invention provides a method of contrast enhanced MR angiography of the human or non-human animal body, said method comprising administering into the vasculature thereof a contrast effective amount of a contrast agent composition comprising magnetic particles having an r2/r1 ratio of no more than 5, and, at a time when sufficient of said magnetic particles remain in the vasculature to provide positive contrast enhancement thereof in a T1-weighted image while sufficient magnetic particles have been taken up into an organ of the reticuloendothelial system to provide negative contrast enhancement thereof in said T1-weighted image, generating a T1-weighted image magnetic resonance image of at least said organ.

摘要翻译： 本发明提供了一种人或非人动物体的造影增强MR血管造影的方法，所述方法包括向其血管中施用造影剂有效量的造影剂组合物，所述造影剂组合物包含r2 / r1比率不超过 如图5所示，并且在足够的所述磁性颗粒保留在脉管系统中以在T1加权图像中提供其正增强的对比度的同时，足够的磁性颗粒已被摄取到网状内皮系统的器官中以提供其负对比度增强 在所述T1加权图像中，生成至少所述器官的T1加权图像磁共振图像。

公开(公告)号：EP0807441A3

公开(公告)日：1999-01-20

申请号：EP97108350.6

申请日：1992-03-28

申请人： NYCOMED IMAGING AS

发明人： Klaveness, Jo ,  Rongved, Pal ,  Strande, Per

IPC分类号： A61K49/00

CPC分类号： A61K49/225 ,  A61K47/26 ,  A61K47/42 ,  A61K49/223 ,  C07C69/96

摘要： Ultrasound contrast agents comprising microbubbles of gas or a gas precusor encapsulated in a protein shell, e.g. of human serum albumin, the protein being crosslinked with biodegradable crosslinking groups, exhibit stability in vivo upon administration so as to permit ultrasound visualisation while allowing rapid subsequent elimination from the system.

公开(公告)号：EP0635278B1

公开(公告)日：1998-12-30

申请号：EP94202117.1

申请日：1994-07-19

申请人： NYCOMED IMAGING AS

发明人： Liebert, Riochard T., c/o Sterling Winthrop INC. ,  Brown, Neil H., c/o Sterling Winthrop INC.

IPC分类号： A61M5/315

CPC分类号： A61M5/14546 ,  A61M5/14566 ,  A61M5/31511 ,  A61M2005/3112

公开(公告)号：EP0885016A1

公开(公告)日：1998-12-23

申请号：EP97903507.0

申请日：1997-02-19

申请人： NYCOMED IMAGING AS

发明人： SWAERD-NORDMO, Marit ,  GULLIKSEN, Per, Helge ,  BRAENDEN, Jorunn, Undheim ,  FAHLVIK, Anne, Kjersti

IPC分类号： A61K9 ,  A61K47 ,  A61K49

CPC分类号： A61K49/223 ,  A61K49/227

摘要： This invention relates to a freeze-dried vesicle containing ultrasound contrast agent containing a freeze-drying stabilizer and thermally stable at temperatures in excess of 20 °C.

公开(公告)号：EP0555900B1

公开(公告)日：1998-09-09

申请号：EP93200190.2

申请日：1993-01-26

申请人： NYCOMED IMAGING AS

发明人： Liebert, Richard T., c/o STERLING WINTHROP INC. ,  Brown, Neil H., c/o STERLING WINTHROP INC. ,  Armbruster, Randy E., c/o EASTMAN KODAK COMPANY ,  Pack, Thomas M., c/o SMITHKLINE BEECHAM

IPC分类号： A61L2/06 ,  A61M5/28

CPC分类号： A61L2/07 ,  A61L2/06 ,  A61M5/178 ,  A61M5/28 ,  A61M5/3145 ,  A61M5/315 ,  A61M5/31505 ,  A61M2005/3121 ,  A61M2005/3128

摘要： A pre-filled plastic syringe (10), container or vial containing a liquid product for terminal sterilization comprising: a barrel (20) equipped with a one-way valve (30) and a slidable plunger (50) to equalize pressure differentials; an optional filter (40) engaging the one way valve to prevent backward migration of viruses and bacteria; an end cap (60) covering the open end (26) of the barrel to maintain sterility; and an end cap restraining device (80) to prevent plunger blow-out is described.

公开(公告)号：EP0660724B1

公开(公告)日：1998-07-01

申请号：EP93919497.3

申请日：1993-09-03

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  RONGVED, P l ,  JOHANSEN, John Henrik ,  FOSS, Per Antonius ,  HOGSET, Anders ,  HVOSLEF, Anne Marie

IPC分类号： A61K49/00

CPC分类号： A61K49/1821 ,  A61K49/18 ,  A61K49/223

摘要： Proteinaceous gas- or gas precursor-containing microbubble contrast agents, e.g. for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g. a dialdehyde such as glutaraldehyde or an α,β-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.

公开(公告)号：EP0799208A1

公开(公告)日：1997-10-08

申请号：EP95941202.0

申请日：1995-12-20

申请人： NYCOMED IMAGING AS ,  MATTHEWS, Derek Peter

发明人： SANDOSHAM, Jessie ,  HIEBL, Johann ,  KOLLMANN, Hermann ,  CUTHBERTSON, Alan ,  FISCHER, Peter ,  HARTMANN, Michael ,  KREMMINGER, Peter ,  ROVENSZKY, Franz ,  HUSBYN, Mette

IPC分类号： C07D213 ,  C07D241 ,  C07D487

CPC分类号： C07D213/82 ,  C07D241/24 ,  C07D487/04

摘要： The present invention relates to pyridine and pyrazine-containing compounds capable of regulating, in particular stimulating, haematopoiesis.

公开(公告)号：EP0677169B1

公开(公告)日：1997-08-13

申请号：EP94904350.9

申请日：1993-12-29

申请人： NYCOMED IMAGING AS

发明人： SAKARIASSEN, Kjell, Steinar

IPC分类号： G01N33/49

CPC分类号： G01N11/08 ,  G01N33/4905

摘要： In a device for in vitro measurement of the tendency to form thrombi in people and animals under simulated in vivo conditions, the blood is pumped at a constant flow through flow channels (7) made of/coated with a thrombogenesis-promoting material, and the pressure difference between the pressures upstream and downstream of the thrombogenesis unit (6), due to a thrombus formed in the flow channel (7), is measured. A method for measuring the tendency to thrombogenesis is also described.