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21.发明公开
公开(公告)号：EP2344206A1
公开(公告)日：2011-07-20
申请号：EP09740172.3
申请日：2009-09-14
发明人： PHAM-HUU, Cuong , KELLER, Nicolas , LEDOUX, Marc-Jacques , KELLER-SPITZER, Valérie , BEGIN, Dominique , BERNHARDT, Pierre , JOSSET, Sébastien , HAJESMAILI, Shabnam , ROMERO, Thierry , WURTZ, Nathanaëlle , DOSS, Nizar
IPC分类号： A61L9/20 , B01D53/85 , B01D53/86 , B01J19/12 , B01J21/18 , B01J27/20 , B01J35/00 , B01J35/04 , C02F1/32 , F24F3/16
CPC分类号： B01J35/004 , A61L9/205 , A61L2209/14 , A61L2209/16 , B01D53/88 , B01D2255/802 , B01J21/063 , B01J21/18 , B01J35/04 , B01J35/1076 , B01J37/0219 , B01J37/0244 , B01J37/084 , C02F1/32 , C02F1/725 , C02F2305/10
摘要： The invention relates to a photocatalyst that comprises a cellular foam selected from carbon foam and the foam of a carbonated material such as a polymer, and a photocatalytically active phase directly deposited on said cellular foam or on an intermediate phase deposited on said cellular foam. The average size of the cells is 2500 μm to 5000 μm. The foam may comprise nanotubes or nanofibres (particularly of TiO
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22.发明公开MONOCLONAL ANTI-CLAUDIN 1 ANTIBODIES FOR THE INHIBITION OF HEPATITIS C VIRUS INFECTION 有权于抑制丙型肝炎病毒单克隆抗紧密连接蛋白-1抗体INFECTION-
公开(公告)号：EP2328933A1
公开(公告)日：2011-06-08
申请号：EP09783424.6
申请日：2009-09-25
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Genovac , Universite De Strasbourg
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/34 , C07K2317/76
摘要： The present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and preventing HCV infection of these cells; and hybridoma cell lines which produce such monoclonal antibodies. Also provided are reagents that comprise such antibodies, and pharmaceutical compositions comprising such antibodies. Methods of treating or preventing HCV infection by administration of an inventive monoclonal antibody, or a pharmaceutical composition thereof are also described.
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23.发明公开
公开(公告)号：EP2294099A1
公开(公告)日：2011-03-16
申请号：EP09766009.6
申请日：2009-06-11
IPC分类号： C08F251/00 , C08F297/02 , C08F2/22 , A61K47/36
CPC分类号： C08F293/00 , A61K9/2846 , A61K31/52 , A61K31/522 , C08F251/00 , C08F293/005 , C08F297/02 , C08L5/00 , C08L51/00 , C08L51/006 , C08L53/00 , C08L2666/02
摘要： The polymers according to the invention comprise a polysaccharide block (17) and several hydrophobic polyacrylic blocks (18) enabling the polymer to remain intact until it reaches the colon. The polysaccharide block is degraded by the colonic microflora irrespective of the pH, while the polyacrylic blocks are solubilized at neutral pH. Colon-specific release of the active ingredients is thus provided in all cases. These polymers may serve as a coating in particular for tablets, gel capsules, granules or microgranules, or serve as matrix agents in the preparation of such pharmaceutical forms. This invention concerns the fields of medicine, pharmacy and dietetics.
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公开(公告)号：EP2188386A2
公开(公告)日：2010-05-26
申请号：EP08804281.7
申请日：2008-09-16
CPC分类号： C12Q1/6827 , C12N15/1086 , C12Q1/6897 , C12Q2561/127
摘要： The present invention discloses a new method for detecting or quantifying a truncating mutation of a target gene in a subject, said method relying on the in vitro compartmentalization of single genetic constructs in aqueous droplets of a water-in-oil emulsion.
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25.发明公开DEVICE FOR SORTING AND CONCENTRATING ELECTROMAGNETIC ENERGY AND APPARATUS COMPRISING AT LEAST ONE SUCH DEVICE 有权分拣装置和电磁能量集中和装置与至少一个这样的设备
公开(公告)号：EP2132556A2
公开(公告)日：2009-12-16
申请号：EP08776261.3
申请日：2008-03-25
申请人： Universite De Strasbourg (Etablissement Public à Caractère Scientifique, Culturel et Professionel) , Centre National de la Recherche Scientifique , Forsvarets Forskningsinstitutt
发明人： EBBESEN, Thomas , SKAULI, Torbjorn
CPC分类号： G02B5/008 , B82Y20/00 , G01J3/02 , G01J3/0208 , G01J3/0216 , G01J3/0224 , G01J3/0256 , G01J3/18 , G01J4/00 , G01N21/21 , G01N21/554 , G02B6/1226 , G02B6/32
摘要： The present invention concerns a device for sorting and concentrating electromagnetic energy impinging a surface of said device, said surface comprising at least one plasmonics-based surface structure or similar structure of periodic or quasi-periodic surface topography. Device characterised in that said surface (V) is provided with at least two such surface structures (2), acting as individual concentrator structures, which are at least partially spatially overlapped or superposed.
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公开(公告)号：EP2389199A2
公开(公告)日：2011-11-30
申请号：EP10700585.2
申请日：2010-01-21
申请人： THE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite De Strasbourg , Institute of Macromolecular Chemistry AS CR v.v.l.
CPC分类号： B82Y5/00 , A61K47/58 , A61K47/6923 , A61K47/6929
摘要： The present invention relates to the field of drug delivery nanosystems. More precisely, the present invention concerns a copolymer with advantageous properties for the outer coating of various nanoparticles. Said copolymer comprises at least three types of monomers with stealthy, coupling and therapeutic properties respectively, as well as an optional fourth type of monomers with targeting properties. The present invention also relates to core-shell or hollow shell nanoparticles coated by an external layer of the copolymer according to the invention. Several types of core-shell nanoparticles are envisaged. The invention also concerns methods for preparing said nanoparticles, as well as pharmaceutical compositions or medicaments comprising them.
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公开(公告)号：EP1812007B1
公开(公告)日：2011-09-07
申请号：EP05823123.4
申请日：2005-11-02
申请人： Northwestern University , Universite De Strasbourg , Centre National de la Recherche Scientifique
发明人： WATTERSON, D. Martin , VAN ELDIK, Linda , HAIECH, Jacques , HIBERT, Marcel , BOURGUIGNON, Jean-jacques , VELENTZA, Anastasia , HU, Wenhui , ZASADZKI, Magdelena
IPC分类号： A61K31/535 , C07D413/00 , A61K31/50 , C07D487/00 , A61K31/495 , C07D237/26 , A01N43/58 , C07D237/36 , A01N43/60
CPC分类号： C07D403/12 , C07D237/36 , C07D401/12 , C07D401/14 , C07D498/06
摘要： The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
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28.发明公开ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTS 审中-公开ROCAGLAOLDERIVATE用作心脏保护剂如抗肿瘤药
公开(公告)号：EP2358694A1
公开(公告)日：2011-08-24
申请号：EP09756321.7
申请日：2009-11-24
IPC分类号： C07D307/93 , A61K31/343 , A61P9/00
CPC分类号： C07D307/93
摘要： The present invention discloses new rocaglaol derivatives and the use of rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent.
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29.发明公开METHOD FOR THE PREPARATION OF FUNCTIONALIZED TRIHALOMETHOXY SUBSTITUTED PYRIDINES 有权用于生产吡啶功能化TRIHALOGENMETHOXYSUBSTITUIERTER
公开(公告)号：EP2350008A1
公开(公告)日：2011-08-03
申请号：EP09778756.8
申请日：2009-09-29
IPC分类号： C07D213/64 , C07D213/65 , C07D213/68 , A61K31/44
CPC分类号： C07D213/64 , C07D213/65 , C07D213/68
摘要： The present invention pertains to a process for the preparation of functionalized trihalomethoxypyridines of formula (I) comprising reacting hydroxypyridines with thiophosgene in the presence of a base; reacting the obtained chlorothionoformiates with elemental chlorine and finally converting trichloromethoxy pyridines to trihalomethoxy pyridines using a fluoride source.
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30.发明授权DEVICE FOR SORTING AND CONCENTRATING ELECTROMAGNETIC ENERGY AND APPARATUS COMPRISING AT LEAST ONE SUCH DEVICE 有权分拣装置和电磁能量集中和装置与至少一个这样的设备
公开(公告)号：EP2132556B1
公开(公告)日：2011-05-11
申请号：EP08776261.3
申请日：2008-03-25
申请人： Universite De Strasbourg (Etablissement Public à Caractère Scientifique, Culturel et Professionel) , Centre National de la Recherche Scientifique , Forsvarets Forskningsinstitutt
发明人： EBBESEN, Thomas , SKAULI, Torbjorn
CPC分类号： G02B5/008 , B82Y20/00 , G01J3/02 , G01J3/0208 , G01J3/0216 , G01J3/0224 , G01J3/0256 , G01J3/18 , G01J4/00 , G01N21/21 , G01N21/554 , G02B6/1226 , G02B6/32
摘要： The present invention concerns a device for sorting and concentrating electromagnetic energy impinging a surface of said device, said surface comprising at least one plasmonics-based surface structure or similar structure of periodic or quasi-periodic surface topography. Device characterised in that said surface (V) is provided with at least two such surface structures (2), acting as individual concentrator structures, which are at least partially spatially overlapped or superposed.
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