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33 条记录 (耗时 0.012 秒)

    Method for the preparation of 2-perfluoroalkyl-3-oxazolin-5-one
    22.
    发明公开
    Method for the preparation of 2-perfluoroalkyl-3-oxazolin-5-one 失效
    制备2-全氟烷基-3-恶唑啉-5-酮的方法

    公开(公告)号：EP0662475A3

    公开(公告)日：1995-07-19

    申请号：EP94117932.7

    申请日：1994-11-14

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D263/42 ,  C07D413/04 ,  C07C255/42 ,  C07D333/24

    CPC分类号： C07D413/04 ,  C07C255/44 ,  C07D263/42 ,  C07D333/24

    摘要： There is provided a method for the preparation of a 2-perfluoroalkyl-3-oxazolin-5-one compound of formula (II) comprising reacting an aminonitrile with a perfluoroacylating agent in the presence of a solvent to form a perfluoroalkanoyl aminonitrile intermediate and cyclizing the intermediate in the presence of an acid and at least one molar equivalent of water. Perfluoro-alkanoyl aminonitrile intermediates are also claimed.

    wherein
    n is an integer of 1,2,3,4,5,6,7 or 8; R is
    L is hydrogen or halogen.

    摘要翻译： 提供了制备式（II）的2-全氟烷基-3-恶唑啉-5-酮化合物的方法，包括使氨基腈与全氟酰化剂在溶剂存在下反应以形成全氟链烷酰氨基腈中间体，并使 在酸和至少一摩尔当量水存在下为中间体。 要求保护全氟链烷酰基氨基腈中间体。 其中n是1,2,3,4,5,6,7或8的整数; R是L是氢或卤素。

    Method for the preparation of 2-perfluoroalkyl-3-oxazolin-5-one
    23.
    发明公开
    Method for the preparation of 2-perfluoroalkyl-3-oxazolin-5-one 失效
    Verfahren zur Herstellung 2-全氟烷基-3-恶唑啉-5-酮。

    公开(公告)号：EP0662475A2

    公开(公告)日：1995-07-12

    申请号：EP94117932.7

    申请日：1994-11-14

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D263/42 ,  C07D413/04 ,  C07C255/42 ,  C07D333/24

    CPC分类号： C07D413/04 ,  C07C255/44 ,  C07D263/42 ,  C07D333/24

    摘要： There is provided a method for the preparation of a 2-perfluoroalkyl-3-oxazolin-5-one compound of formula (II) comprising reacting an aminonitrile with a perfluoroacylating agent in the presence of a solvent to form a perfluoroalkanoyl aminonitrile intermediate and cyclizing the intermediate in the presence of an acid and at least one molar equivalent of water. Perfluoro-alkanoyl aminonitrile intermediates are also claimed.

    wherein

    n is an integer of 1,2,3,4,5,6,7 or 8;
    R is

    L is hydrogen or halogen.

    摘要翻译： 提供了制备式（II）的2-全氟烷基-3-恶唑啉-5-酮化合物的方法，包括使氨基腈与全氟酰基化剂在溶剂存在下反应形成全氟烷酰基氨基腈中间体，并使 在酸和至少一摩尔当量的水的存在下中间体。 全氟烷基氨基腈中间体也被要求保护。 其中n是1,2,3,4,5,6,7或8的整数; L是氢或卤素

    Process for the preparation of molluscicidal 2,4,5-tribromopyrrole-3-carbonitrile compounds
    24.
    发明公开
    Process for the preparation of molluscicidal 2,4,5-tribromopyrrole-3-carbonitrile compounds 失效
    Verfahren zur Herstellung von molluskiziden 2,4,5-Tribrom pyrrol-3-Carbonitrilen。

    公开(公告)号：EP0431305A1

    公开(公告)日：1991-06-12

    申请号：EP90120661.5

    申请日：1990-10-29

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D207/34

    CPC分类号： C07D207/34

    摘要： There is provided a method of preparation of 2,4,5-tribromopyrrole-3-carbonitrile compounds in a single step from their 2-trihaloacetylpyrrole-4-carbonitrile precursors. The 2,4,5-tribromopyrrole-3-carbonitrile compounds are useful as molluscicidal agents.

    摘要翻译： 提供了从2-三卤代乙酰基吡咯-4-腈前体在一个步骤中制备2,4,5-三溴吡咯-3-腈化合物的方法。 2,4,5-三溴吡咯-3-腈化合物可用作杀软体动物剂。

    Method for the resolution of racemic 2-CP-difluoromethoxy phenyl)-3-methylbutyric acid
    26.
    发明公开
    Method for the resolution of racemic 2-CP-difluoromethoxy phenyl)-3-methylbutyric acid 失效
    拆分外消旋2-CP-二氟甲氧基苯基）-3-甲基丁酸的方法

    公开(公告)号：EP0101570A1

    公开(公告)日：1984-02-29

    申请号：EP83107272.3

    申请日：1983-07-25

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Kameswaran, Venkataraman ,  Siddens, Jack Kenneth ,  Raghu, Sivaraman

    IPC分类号： C07C69/734 ,  C07C67/317 ,  C07C121/75 ,  C07C120/00 ,  C07C43/225 ,  C07C79/35 ,  C07C76/00 ,  C07B57/00 ,  C07C59/64 ,  C07C27/02

    CPC分类号： C07C255/00 ,  C07B2200/07 ,  C07C41/16 ,  C07C43/225 ,  C07C51/367 ,  C07C51/412 ,  C07C51/487 ,  C07C67/14 ,  C07C67/31 ,  C07C201/12 ,  C07C253/30 ,  C07C253/34 ,  C07C59/64 ,  C07C205/37 ,  C07C255/38 ,  C07C255/37 ,  C07C69/734

    摘要： A method for the preparation of certain difluoromethoxyaromatic compounds useful as intermediates in the preparation of pyrethroid pesticides. The method comprises alkylating a p-substituted phenol with excess chlorodifluoromethane at atmospheric or superatmospheric pressure in the presence of a base, water, and an inert water miscible organic solvent or solvent mixture, alone or in the presence of benzyltriethylammonium chloride, to yield a difluoromethoxyaromatic compound; and, when said difluoroaro- matic compound contains a side chain acetic acid ester having a chiral center, optionally, (a) hydrolyzing said ester to the corresponding racemic acid and thereafter resolving said racemic acid into its dextrorotatory (+) acid and levorotatory (-) acid isomers and recovering said (+) acid isomer, or (b) hydrolyzing said ester to the corresponding racemic acid, resolving said racemic acid into its d(+) acid and I(-) acid isomers, recovering said d(+) acid for use in the preparation of pyrethroid product, esterifying the above-said I(-) acid from the resolution, racemizing the thus-prepared 1(-) ester from said esterification, and hydrolyzing the same to obtain racemic acid which is recycled for admixture with the fresh racemic acid and subsequent resolution.

    摘要翻译： 一种制备某些二氟甲氧基芳族化合物的方法，该化合物可用作制备拟除虫菊酯农药的中间体。 该方法包括在常压或超大气压下，在碱，水和惰性水混溶性有机溶剂或溶剂混合物存在下，单独或在苄基三乙基氯化铵存在下，用过量的氯二氟甲烷将对位取代苯酚烷基化，得到二氟甲氧基芳族化合物 复合; 并且当所述二氟代硫酸盐化合物含有具有手性中心的侧链乙酸酯时，任选地，（a）将所述酯水解成相应的外消旋酸，然后将所述外消旋酸分解成其右旋（+）酸和左旋（ - ）酸异构体并回收所述（+）酸异构体，或（b）将所述酯水解成相应的外消旋酸，将所述外消旋酸拆分成其d（+）酸和I（ - ）酸异构体，回收所述d（+ 用于制备拟除虫菊酯产物，从该分辨率酯化上述I（ - ）酸，将由此制备的1（ - ）酯从所述酯化作用外消旋化，并将其水解，得到外消旋酸 与新鲜外消旋酸混合并随后分离。

    Process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl)methyl]arylimidoyl chloride compounds
    27.
    发明公开
    Process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl)methyl]arylimidoyl chloride compounds 有权
    Verfahren zur Herstellung von 2-芳基-5-（全氟烷基）吡咯烷二酮N- [1-氯-1-（全氟烷基）甲基]芳基亚氨基氯 - 维生素

    公开(公告)号：EP1035113A2

    公开(公告)日：2000-09-13

    申请号：EP00301810.8

    申请日：2000-03-06

    申请人： American Cyanamid Company

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D207/34 ,  C07C257/02 ,  C07C233/69 ,  C07C233/66

    CPC分类号： C07D207/34 ,  C07C233/69 ,  C07C251/24

    摘要： There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds of formula I from N-[1-chloro-1-(perfluoroalkyl)methyl]arylimidoyl chloride compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole compounds are useful for the control of insect and acarid pests, and may also be used to prepare other pesticidal arylpyrrole compounds.
    In addition, the present invention provides compounds which are useful as intermediates in the preparation of arylpyrrole compounds.

    摘要翻译： 提供了由N-1-氯-1-（全氟烷基）甲基亚氨基亚氨基氯化合物制备式I的2-芳基-5-（全氟烷基）吡咯化合物的方法。 2-芳基-5-（全氟烷基）吡咯化合物可用于防治昆虫和螨类害虫，也可用于制备其他杀虫芳基吡咯化合物。 此外，本发明提供了可用作制备芳基吡咯化合物的中间体的化合物。

    Ammonium oxazole- and amino oxazolium intermediates, methods for their preparation and their use in the manufacture of insecticidal, acaricidal and nematocidal arylpyrrole derivatives
    28.
    发明公开
    Ammonium oxazole- and amino oxazolium intermediates, methods for their preparation and their use in the manufacture of insecticidal, acaricidal and nematocidal arylpyrrole derivatives 失效
    恶唑铵和氨基恶唑鎓中间体，其制备方法及其在杀虫，杀螨和杀线虫的芳基吡咯衍生物的制备用

    公开(公告)号：EP0816347A1

    公开(公告)日：1998-01-07

    申请号：EP97304498.5

    申请日：1997-06-25

    申请人： American Cyanamid Company

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D263/48 ,  C07D207/40

    CPC分类号： C07D207/416 ,  C07D263/48

    摘要： A method for the preparation of a compound of formula IV
    wherein W is CN, NO 2 , COOR 1 or COR 2 ;
    R 1 and R 2 are each independently C 1 -C 4 alkyl;
    R' is hydrogen or R;
    R is C 1 -C 6 alkyl optionally substituted with one C 1 -C 4 alkoxy or phenyl group;
    n is an integer of 1, 2 , 3, 4, 5, 6, 7 or 8;
    A is


    L is hydrogen or halogen;
    M and Q are each independently hydrogen, halogen, CN, NO 2 , C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 haloalkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl or when M and Q are on adjacent positions they may be taken together with the carbon atoms to which they are attached to form a ring in which MQ represents the structure

            -OCH 2 O-, -OCF 2 O- or -CH=CH-CH=CH-;


    R 1 and R 2 are each independently C 1 -C 4 alkyl;
    R 3 , R 4 and R 5 are each independently hydrogen, halogen, NO 2 , CHO or R 4 and R 5 may be taken together with the atoms to which they are attached to form a ring in which R 4 R 5 is represented by the structure

    R 6 , R 7 , R 8 and R 9 are each independently hydrogen, halogen, CN or NO 2 ; and
    X is O or S
    which comprises reacting an intermediate compound of formula I or formula II wherein n, A and R are as
    described hereinabove for formula IV and q is an integer of 1, 2, or 3 and Anion -q is a proton acceptor having a negative q charge with at least q molar equivalents of a dieneophile of formula V
    wherein W is as described hereinabove for formula (IV) and Y is hydrogen, Cl or Br with the proviso that when said intermediate compound is formula I then Y must be Cl or Br, in the presence of a solvent and essentially in the absence of water.
    There are also provided ammonium oxazole intermediates of formula I and amino oxazolium intermediates of formula II, useful in the manufacture of insecticidal arylpyrrole compounds.

    摘要翻译： 一种用于式IV 的化合物的制备方法worin W是CN，NO 2，COOR 1或COR 2; R1和R2各自独立地是C1-C4烷基; R“是氢或R; R是C 1-6烷基任选被一个C 1-4烷氧基或苯基substituiertem; n为1的整数，2，3，4，5，6，7或8; A是 L是氢或卤素; M和Q各自独立地是氢，卤素，CN，NO2，C1-C4烷基，C1-C4卤代烷基，C1 4烷氧基，C1-C4卤代烷氧基，C1-C4烷硫基，C1-C4烷，或当M和Q处于毗邻位置时，可采取 连同的碳原子它们所连接以形成环，其中MQ代表结构：-OCH 2 O - ，-OCF 2 O-或-CH = CH-CH = CH-; R1和R2各自独立地是C1-C4烷基; R3，R4和R5各自unabhängig氢，卤素，NO2，CHO或R4和R5可一起与其连接的原子以它们所连接以形成其中R4R5一个环是由以下结构代表 R6，R7， R8和R9各自unabhängig氢，卤素，CN或NO 2; 和X是O或S该方法包括使式I的中间体化合物I或式II worin N，A和R如在上述的式IV和q为1，2或3，阴离子<整数 - q>是具有至少为q的负q电荷式V worin W如在上文关于式质子受体（IV），Y为氢，Cl或Br，条件没有当 所述中间体化合物是式I，则Y必须是Cl或Br，在溶剂的存在下和在不存在水本质上。 所以，提供了式II的杀虫化合物芳基吡咯的制造中有用的式I和氨基恶唑鎓中间体的恶唑铵中间体。

    Process for the manufacture of insecticidal arylpyrroles via oxazole amine intermediates
    29.
    发明公开
    Process for the manufacture of insecticidal arylpyrroles via oxazole amine intermediates 失效
    Verfahren zur Herstellung vor insektiziden Aryl pyrrolen aus Oxazolamin Zwischenprodukte

    公开(公告)号：EP0713868A1

    公开(公告)日：1996-05-29

    申请号：EP95308298.9

    申请日：1995-11-21

    申请人： American Cyanamid Company

    发明人： Kameswaran, Venkataraman

    IPC分类号： C07D207/34 ,  C07D263/48

    CPC分类号： C07D207/34

    摘要： The present invention provides a process for the manufacture of 2-aryl-5-(perfluoroalkyl)pyrrole-3-carbonitrile comprising the cycloaddition of 5-amino-4-aryl-2-perfluoroalkyl-1,3-oxazole and the appropriate 1,3-dipolarifile. The arylpyrrole-3-carbonitrile product and its derivatives are highly effective insecticidal, acaricidal and nematocidal agents.

    摘要翻译： Prodn。 式（I）的2-芳基-5-全氟烷基 - 吡咯-3-腈的方法包括使式（II）的5-酰基氨基-4-芳基-2-全氟烷基恶唑或（II）的互变异构体与至少1 摩尔当量 的2-卤代丙烯腈或2,3-二卤代丙腈在碱存在下反应。 溶剂。 n = 1-8; A = gp 例如。 （A1）：L = H或卤素; M，Q = H，卤素，CN，NO 2等; 或相邻的M + Q = OCH 2 O，OCF 2 O或CH = CH-CH = CH; R = 1-6C烷基，1-6C卤代烷基，COOR1等; R1 = 1-4C烷基或1-4C卤代烷基。