摘要:
The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device at reaction temperatures of less than about 55 °c.
wherein R 1 , R 2 , R 3 , R 4 , R 7 and R 8 are independently selected from hydrogen, C 1 -C 4 alkyl, C 1 -C 2 alkanol or hydroxyl; A is O, O(CH 2 CH 2 O) v or [SiR 5 R 6 O] w SiR 5 R 6 , wherein R 5 and R 6 are independently selected from C 1-4 alkyl or phenyl, and v is from 1-20 and w is from 0 to 60; m and n are integers independently selected from 1 to 10; p is 0 or 1; and q is an integer from 0 to 6; and X and Y are independently selected from O or NR 9 , wherein R 9 is hydrogen, C 1 -C 4 alkyl or C 1 -C 2 alkanol.
摘要:
Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising one or more random copolymers comprising hydrophilic units and hydrophobic units, wherein the one or more random copolymers have at least one thio carbonyl thio fragment of a reversible addition fragmentation chain transfer ("RAFT") agent are disclosed.
摘要:
The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.
摘要:
A new class of polymerizable surfactants, useful for modifying the surfaces of polymeric objects, which are described by the formula: DC[AxBy] wherein A is at least one ethylenically unsaturated hydrophilic monomer, B is at least one ethylenically unsaturated hydrophobic monomer, C is a functional chain transfer agent, D is an ethylenically unsaturated end group, y is within the range from about 0.1 to about 0.9, and x + y = 1. Also disclosed are random copolymer precursors of such polymerizable surfactants.
摘要:
Nouvelle classe de tensioactifs polymérisables décrits par la formule (DC[AxBy], permettant de modifier les surfaces d'objets polymères. Dans la formule, A représente au moins un monomère hydrophyle à insaturation éthylénique, B représente au moins un monomère hydrophobe à insaturation éthylénique, D est un groupe terminal à insaturation éthylénique, y est compris entre environ 0,1 et environ 0,9 et x + y = 1. On décrit également des précurseurs copolymères non orientés de ces tensioactifs polymérisables.