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公开(公告)号：EP1554379A2
公开(公告)日：2005-07-20
申请号：EP03769780.2
申请日：2003-10-02
申请人： FIRMENICH SA
发明人： SCHALK, Michel , CLARK, Anthony
IPC分类号： C12N9/88
CPC分类号： C12N9/88
摘要： The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert famesyl-pyrophosphate to various oxygenated and aliphatic sesquiterpenes including valencene, bicyclo-germacrene, cubebol and delta- cadinene.
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公开(公告)号：EP3488008A2
公开(公告)日：2019-05-29
申请号：EP17748680.0
申请日：2017-07-19
申请人： Firmenich SA
发明人： SCHALK, Michel , ROCCI, Letizia
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公开(公告)号：EP3241906A1
公开(公告)日：2017-11-08
申请号：EP17158775.1
申请日：2009-12-09
申请人： Firmenich SA
发明人： SCHALK, Michel
CPC分类号： C12P5/002 , C12N9/88 , C12P5/007 , C12Y402/03083
摘要： The present invention provides a method of producing β-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce β-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing β-santalene is also an object of the present invention.
摘要翻译： 本发明提供了生产β-檀香萜的方法，所述方法包括使至少一种多肽与焦磷酸法呢酯（FPP）接触。 特别地，所述方法可以在体外或体内进行以产生β-檀香萜，在香料和调味剂领域非常有用的化合物。 本发明还提供了可用于本发明方法的多肽的氨基酸序列。 编码本发明多肽的核酸和含有所述核酸的表达载体也是本发明的一部分。 非人类宿主生物或经转化用于生产β-檀香萜的方法中的细胞也是本发明的目的。
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公开(公告)号：EP2800818B1
公开(公告)日：2017-07-26
申请号：EP12801747.2
申请日：2012-12-17
申请人： Firmenich SA
发明人： NIELSEN, Jens , SIEWERS, Verena , CHEN, Yun , DAVIET, Laurent , SCHALK, Michel
IPC分类号： C12P7/16 , C12P7/62 , C12R1/865 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/00 , C12N15/81 , C12P5/00
CPC分类号： C12N15/81 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/93 , C12P5/007 , C12P7/16 , C12P7/625 , C12Y101/01002 , C12Y102/01004 , C12Y203/01009 , C12Y602/01001 , Y02E50/10
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公开(公告)号：EP3140410A2
公开(公告)日：2017-03-15
申请号：EP15730972.5
申请日：2015-05-06
申请人： Firmenich SA
CPC分类号： C12P7/02 , C12N9/0004 , C12N9/16 , C12P7/04 , C12Y301/07007
摘要： The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.
摘要翻译： 本发明涉及通过使至少一种多肽与二磷酸法呢酯接触来生产drimenol和/或drimenol衍生物的方法。 该方法可以在体外或体内进行。 本发明还提供了可用于本发明方法的多肽的氨基酸序列和编码本发明多肽的核酸。 该方法进一步提供了经遗传修饰以表达本发明多肽并可用于生产drimenol和/或drimenol衍生物的宿主细胞或生物体。
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27.发明授权CYTOCHROME P450 AND USE THEREOF FOR THE ENZYMATIC OXIDATION OF TERPENES 有权CYTOCHROME P450 UND SEINE VERWENDUNGFÜRDIE ENZYMATISCHE OXIDIERUNG VON TERPENEN
公开(公告)号：EP2773751B1
公开(公告)日：2017-03-01
申请号：EP12778111.0
申请日：2012-10-25
申请人： Firmenich SA
发明人： SCHALK, Michel , DEGUERRY, Fabienne
CPC分类号： C12P5/007 , C12N9/0071 , C12P7/02 , C12P7/24 , C12P7/40
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公开(公告)号：EP1697519B1
公开(公告)日：2009-03-04
申请号：EP04798949.6
申请日：2004-11-19
申请人： FIRMENICH SA
摘要： The invention relates to sesquiterpene synthases from Patchouli plants (Pogostemon cablin), and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthase. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various sesquiterpenes including patchoulol, Ϝ-curcumene and other germacrane-type sesquiterpenes.
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公开(公告)号：EP1697519A2
公开(公告)日：2006-09-06
申请号：EP04798949.6
申请日：2004-11-19
申请人： FIRMENICH SA
发明人： SCHALK, Michel
摘要： The invention relates to sesquiterpene synthases from Patchouli plants (Pogostemon cablin), and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthase. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various sesquiterpenes including patchoulol, Ϝ-curcumene and other germacrane-type sesquiterpenes.
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