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公开(公告)号：EP2334433B1
公开(公告)日：2012-08-15
申请号：EP09787341.8
申请日：2009-10-01
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/087 , B01L2400/043 , B01L2400/086
摘要： A microfluidic device is provided, the microfluidic device comprising: a plurality of chambers (3, 4, 5, 6) adapted for performing chemical, biochemical, or physical processes and a flow path (9) connecting the plurality of chambers (3, 4, 5, 6) adapted for accommodating at least one magnetic particle (7) subsequently moving through the plurality of chambers The plurality of chambers (3, 4, 5, 6) are separated by at least one valve-like structure (10) adapted to enable passing-through of the at least one magnetic particle (7) from one of the plurality of chambers to another one of the plurality of chambers. At least one delaying structure (11, 111) adapted to delay movement of the at least one magnetic particle (7) along the flow path is provided.
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公开(公告)号：EP2379212A1
公开(公告)日：2011-10-26
申请号：EP09786429.2
申请日：2009-06-17
摘要： The present invention relates to a hydrophobic valve for liquids having an appreciable surface tension comprising magnetic particles, said device comprising at least two planar solid substrates with a functionalized surface each, wherein at least a first solid substrate has a patterned surface comprising at least two hydrophilic areas separated from one another by at least one hydrophobic area, wherein the said two planar substrates are disposed with a distance to one another in a sandwiched, parallel fashion, in such way that said functionalized surfaces are facing one another, said valve further comprising a magnetic actuator.
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公开(公告)号：EP2265930A2
公开(公告)日：2010-12-29
申请号：EP09729678.4
申请日：2009-04-07
发明人： SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
CPC分类号： G01N21/253 , G01N21/41 , G01N2021/0346 , G01N2021/435
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (L1) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.
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公开(公告)号：EP2240278A1
公开(公告)日：2010-10-20
申请号：EP08868852.8
申请日：2008-12-16
发明人： PRINS, Menno, W., J. , MAAS, Joost, H. , IMMINK, Albert, H., J. , VAN DAM, Dirkjan, B. , KOETS, Maatje , BRUYNINCKX, Michel, J., M. , VAN DER WIJK, Thea , BOAMFA, Marius, I. , DEN DULK, Remco
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L2200/0647 , B01L2300/089 , B01L2300/161 , B01L2400/043 , B01L2400/0688 , B01L2400/088
摘要： The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
摘要翻译： 本发明公开了具有阀状结构（3）的微流体装置，通过该微流体装置可以以最小的流体输送运输磁性颗粒。 这允许顺序处理磁性颗粒。
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公开(公告)号：EP1904840A2
公开(公告)日：2008-04-02
申请号：EP06765932.6
申请日：2006-06-28
IPC分类号： G01N33/487
CPC分类号： G01N27/745 , H01L21/568 , H01L2224/16245 , H01L2224/81005 , H01L2924/15747 , H01L2924/00
摘要： The present invention provides a packed semiconductor sensor chip ( 10 ) in which the sensing circuit ( 17 ) is positioned at substantially the same level or above the level of the packaging ( 13 ). Because of this, when the sensor is immersed in a fluid, in particular in a liquid, for the detection of an analyte in the fluid, substantially the total top surface of the semiconductor sensor chip will be in contact with the fluid and thus detection results can be optimised.
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公开(公告)号：EP1894009A2
公开(公告)日：2008-03-05
申请号：EP06765725.4
申请日：2006-06-12
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N27/745 , G01N33/54366
摘要： The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.
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27.发明公开
公开(公告)号：EP1163681A1
公开(公告)日：2001-12-19
申请号：EP00969366.4
申请日：2000-09-28
发明人： WEEKAMP, Johannus, W. , GIESBERS, Jacobus, B. , VAN NUNEN, Bartholomeus, P., H. , VAN KASTEREN, Adrianus, C. , PRINS, Menno, W., J.
IPC分类号： G21K1/10
CPC分类号： G21K1/10
摘要： A method of manufacturing a filter which is provided with a number of ducts, wherein: a number of deformable foils is provided, on electrically insulating outer sides, with electrically conductive bands which are separated from one another by electrically insulating bands, the electrically conductive bands on a first outer side of the foil are arranged so as to be offset relative to the electrically conductive bands on the second outer side of the foil; the foils are stacked; oppositely situated electrically insulating bands of the oppositely situated foils are interconnected; the foils are ultimately moved away from one another in a direction transversely of the foils in order to form the ducts between the interconnected foils. At least one detached, electrically insulating section is situated in a prolongation of at least one electrically conductive band and is not connected to an oppositely situated foil.
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28.发明公开
公开(公告)号：EP1048039A1
公开(公告)日：2000-11-02
申请号：EP99955967.7
申请日：1999-11-04
发明人： YOUNG, Edward, W., A. , PRINS, Menno, W., J. , WEEKAMP, Johannes, W. , GIESBERS, Jacobus, B. , LINDERS, Petrus, W., J. , VAN NES, Andreas, C., M.
IPC分类号： G21K1/10
CPC分类号： G21K1/10
摘要： The X-ray examination apparatus includes an X-ray source, an X-ray detector and an X-ray filter which is located between the X-ray source and the X-ray detector. The X-ray filter includes elements, notably capillary tubes, and the X-ray absorptivity of separate filter elements is adjustable by adjustment of a quantity of X-ray absorbing liquid in the respective filter elements. The quantity of X-ray absorbing liquid in the individual filter elements is adjusted by way of electric voltages applied to the individual filter elements. A control system is provided to apply the electric voltages selectively to the individual filter elements. The control system includes voltage lines and switching elements which electrically couple the filter elements to an electric voltage source. The filter elements are formed by spaces between corrugated plates or parallel plates provided with separating members, such as protrusions which extend transversely of the plates. The voltage lines are disposed on the plates. Preferably, the plates are formed from a stack of extendable wall foils and separating foils are provided partially between the wall foils so as to adapt the spacing of the voltage lines to the spacing of the switching elements.
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公开(公告)号：EP2326956A1
公开(公告)日：2011-06-01
申请号：EP09787103.2
申请日：2009-09-04
IPC分类号： G01N33/543 , G01N35/00
CPC分类号： G01N33/54333 , G01N27/745
摘要： In a method of performing a cluster assay, a suspension (14) of superparamagnetic particles in a fluid to be analyzed is provided, wherein the superparamagnetic particles are coated with a bioactive agent. The particles are then allowed to form clusters due to an analyte present within the fluid. Subsequently, clusters of superparamagnetic particles are selectively actuated by applying a rotating magnetic field, wherein the amplitude of the magnetic field varies over time. Finally, the selectively actuated clusters are detected. An apparatus for performing a cluster assay comprises means for accommodating a sample (12) and means for applying a rotating magnetic field (11), the magnetic field being adapted for selectively actuating clusters of superparamagnetic particles. The apparatus further comprises means for detecting the selectively actuated clusters.
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公开(公告)号：EP2171491A2
公开(公告)日：2010-04-07
申请号：EP08789314.5
申请日：2008-07-16
发明人： IMMINK, Albert, H., J. , DE THEIJE, Femke, K. , PRINS, Menno, W., J. , DITTMER, Wendy, U. , NIEUWENHUIS, Jeroen, H.
IPC分类号： G01R33/09
CPC分类号： G01R33/1269
摘要： The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).
摘要翻译： 本发明提供了一种用于区别确定流体样本中的至少两个不同目标部分的传感器盒（10）。 传感器盒（10）包括反应室（1）和至少一个彼此不同的第一和第二区域（2,3）。 第一区域（2）包括用第一类探针标记的用于特异性结合第一类型靶标部分的磁性或可磁化物体（4a），第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b） 用于特异性结合第二类型目标部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可直接与样品流体接触。 本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同目标部分的存在和/或量的方法。
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